Mathias Linnerbauer
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View article: Gut-specific histamine 3 receptor signaling orchestrates microglia-dependent resolution of peripheral inflammation
Gut-specific histamine 3 receptor signaling orchestrates microglia-dependent resolution of peripheral inflammation Open
Chronic inflammatory diseases like rheumatoid arthritis (RA) have been described to cause CNS activation. Less is known about environmental factors that enable the CNS to suppress peripheral inflammation in RA. Here, we identified gut micr…
View article: TGFα controls checkpoints in CNS resident and infiltrating immune cells to promote resolution of inflammation
TGFα controls checkpoints in CNS resident and infiltrating immune cells to promote resolution of inflammation Open
After acute lesions in the central nervous system (CNS), the interaction of microglia, astrocytes, and infiltrating immune cells decides over their resolution or chronification. However, this CNS-intrinsic cross-talk is poorly characterize…
View article: Gut–Brain Interactions and Their Impact on Astrocytes in the Context of Multiple Sclerosis and Beyond
Gut–Brain Interactions and Their Impact on Astrocytes in the Context of Multiple Sclerosis and Beyond Open
Multiple Sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous system (CNS) that leads to physical and cognitive impairment in young adults. The increasing prevalence of MS underscores the critical need for inn…
View article: The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology
The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology Open
View article: The role of midkine in health and disease
The role of midkine in health and disease Open
Midkine (MDK) is a neurotrophic growth factor highly expressed during embryogenesis with important functions related to growth, proliferation, survival, migration, angiogenesis, reproduction, and repair. Recent research has indicated that …
View article: PD-L1 positive astrocytes attenuate inflammatory functions of PD-1 positive microglia in models of autoimmune neuroinflammation
PD-L1 positive astrocytes attenuate inflammatory functions of PD-1 positive microglia in models of autoimmune neuroinflammation Open
Multiple Sclerosis (MS) is a chronic autoimmune inflammatory disorder of the central nervous system (CNS). Current therapies mainly target inflammatory processes during acute stages, but effective treatments for progressive MS are limited.…
View article: Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells
Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells Open
View article: Microglial expression of CD83 governs cellular activation and restrains neuroinflammation in experimental autoimmune encephalomyelitis
Microglial expression of CD83 governs cellular activation and restrains neuroinflammation in experimental autoimmune encephalomyelitis Open
Microglial activation during neuroinflammation is crucial for coordinating the immune response against neuronal tissue, and the initial response of microglia determines the severity of neuro-inflammatory diseases. The CD83 molecule has bee…
View article: POS0002 MICROBIOTA-DERIVED HISTAMINE INDUCES RESOLUTION OF SYNOVIAL INFLAMMATION VIA CELLS OF THE NERVOUS SYSTEM
POS0002 MICROBIOTA-DERIVED HISTAMINE INDUCES RESOLUTION OF SYNOVIAL INFLAMMATION VIA CELLS OF THE NERVOUS SYSTEM Open
View article: Engineered probiotics limit CNS autoimmunity by stabilizing HIF-1α in dendritic cells
Engineered probiotics limit CNS autoimmunity by stabilizing HIF-1α in dendritic cells Open
Summary Dendritic cells (DCs) control the generation of self-reactive pathogenic T cells. Thus, DCs are considered attractive therapeutic targets for autoimmune diseases. Using single-cell and bulk transcriptional and metabolic analyses in…
View article: Droplet-based forward genetic screening of astrocyte–microglia cross-talk
Droplet-based forward genetic screening of astrocyte–microglia cross-talk Open
Cell–cell interactions in the central nervous system play important roles in neurologic diseases. However, little is known about the specific molecular pathways involved, and methods for their systematic identification are limited. Here, w…
View article: Regulation of the programmed cell death protein 1/programmed cell death ligand 1 axis in relapsing–remitting multiple sclerosis
Regulation of the programmed cell death protein 1/programmed cell death ligand 1 axis in relapsing–remitting multiple sclerosis Open
The programmed cell death protein 1/programmed cell death ligand 1 axis plays an important role in the adaptive immune system and has influence on neoplastic and inflammatory diseases, while its role in multiple sclerosis is unclear. Here,…
View article: Cerebrospinal fluid biomarkers for cerebral amyloid angiopathy
Cerebrospinal fluid biomarkers for cerebral amyloid angiopathy Open
Integrating cerebrospinal fluid-biomarkers into diagnostic workup of patients with sporadic cerebral amyloid angiopathy may support early and correct identification. We aimed to identify and validate clinical- and cerebrospinal fluid-bioma…
View article: Microglial expression of CD83 governs cellular activation and restrains autoimmune neuroinflammation
Microglial expression of CD83 governs cellular activation and restrains autoimmune neuroinflammation Open
Microglial activation during neuroinflammation is crucial for coordinating the immune response against neuronal tissue and the initial response of microglia determines the severity of neuroinflammatory diseases. CD83 has been associated wi…
View article: Identification of environmental factors that promote intestinal inflammation
Identification of environmental factors that promote intestinal inflammation Open
View article: Identification of four novel T cell autoantigens and personal autoreactive profiles in multiple sclerosis
Identification of four novel T cell autoantigens and personal autoreactive profiles in multiple sclerosis Open
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS), in which pathological T cells, likely autoimmune, play a key role. Despite its central importance, the autoantigen repertoire remains largely uncharact…
View article: Intranasal delivery of a small-molecule ErbB inhibitor promotes recovery from acute and late-stage CNS inflammation
Intranasal delivery of a small-molecule ErbB inhibitor promotes recovery from acute and late-stage CNS inflammation Open
Multiple sclerosis (MS) is an autoimmune inflammatory disease of the CNS that is characterized by demyelination and axonal degeneration. Although several established treatments reduce relapse burden, effective treatments to halt chronic pr…
View article: The Aryl Hydrocarbon Receptor–Dependent TGF-α/VEGF-B Ratio Correlates With Disease Subtype and Prognosis in Multiple Sclerosis
The Aryl Hydrocarbon Receptor–Dependent TGF-α/VEGF-B Ratio Correlates With Disease Subtype and Prognosis in Multiple Sclerosis Open
This study provides Class III evidence that serum levels of AHR, TGF-α, and VEGF-B distinguish subtypes of MS and predict the severity and disease activity of MS.
View article: Barcoded viral tracing of single-cell interactions in central nervous system inflammation
Barcoded viral tracing of single-cell interactions in central nervous system inflammation Open
Single-cell analysis of CNS interactions Despite their importance in the physiology and pathology of the central nervous system (CNS), few methods are available for the unbiased, systematic investigation of cell-to-cell interactions at sin…
View article: Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes
Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes Open
View article: Aryl Hydrocarbon Receptor Plasma Agonist Activity Correlates With Disease Activity in Progressive MS
Aryl Hydrocarbon Receptor Plasma Agonist Activity Correlates With Disease Activity in Progressive MS Open
These findings suggest that serum AHR agonist levels negatively correlate with disability in RRMS and PMS and decrease longitudinally in correlation with MRI markers of disease progression. Thus, serum AHR agonistic activity may serve as n…
View article: Protective Functions of Reactive Astrocytes Following Central Nervous System Insult
Protective Functions of Reactive Astrocytes Following Central Nervous System Insult Open
Astrocytes play important roles in numerous central nervous system disorders including autoimmune inflammatory, hypoxic, and degenerative diseases such as Multiple Sclerosis, ischemic stroke, and Alzheimer's disease. Depending on the spati…
View article: Astrocyte Crosstalk in CNS Inflammation
Astrocyte Crosstalk in CNS Inflammation Open