Mathieu Bottier
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View article: Inflammatory and Mucociliary Dysfunction-Based Endotypes Across the Spectrum of Chronic Airway Diseases
Inflammatory and Mucociliary Dysfunction-Based Endotypes Across the Spectrum of Chronic Airway Diseases Open
Airway diseases have heterogeneous mucus properties. Patients cluster according to inflammatory endotype rather than disease label. Assessment based on disease labels may be aided by endotyping using inflammatory and mucociliary clearance …
View article: Airway IL-1β is related to disease severity and mucociliary function in bronchiectasis
Airway IL-1β is related to disease severity and mucociliary function in bronchiectasis Open
Rationale The inflammasome is a key regulatory complex of the inflammatory response leading to interleukin-1β (IL-1β) release and activation. IL-1β amplifies inflammatory responses and induces mucus secretion and hyperconcentration in othe…
View article: Ciliopathy patient variants reveal organelle-specific functions for TUBB4B in axonemal microtubules
Ciliopathy patient variants reveal organelle-specific functions for TUBB4B in axonemal microtubules Open
Tubulin, one of the most abundant cytoskeletal building blocks, has numerous isotypes in metazoans encoded by different conserved genes. Whether these distinct isotypes form cell type– and context-specific microtubule structures is poorly …
View article: S83 Long-term effects of SARS-CoV-2 on ciliogenesis through altered expression of FOXJ1
S83 Long-term effects of SARS-CoV-2 on ciliogenesis through altered expression of FOXJ1 Open
Introduction Cilia are critically important in the mucociliary clearance of the airways. This study explores the long-term effects of SARS-CoV-2 on cilial function and regeneration. Aim We aimed to investigate respiratory epithelial recove…
View article: Axonemal structures reveal mechanoregulatory and disease mechanisms
Axonemal structures reveal mechanoregulatory and disease mechanisms Open
Motile cilia and flagella beat rhythmically on the surface of cells to power the flow of fluid and to enable spermatozoa and unicellular eukaryotes to swim. In humans, defective ciliary motility can lead to male infertility and a congenita…
View article: <i>TUBB4B</i>variants specifically impact ciliary function, causing a ciliopathic spectrum
<i>TUBB4B</i>variants specifically impact ciliary function, causing a ciliopathic spectrum Open
Cilia are small microtubule-based structures found on the surface of most mammalian cells, which have key sensory and sometimes motile functions. Primary ciliary dyskinesia (PCD) is a type of ciliopathy caused by defects in motile cilia. T…
View article: S55 Persistent changes to the nasal ciliated epithelium following SARS-CoV2 infection: a longitudinal cohort analysis from FOLLOW-COVID
S55 Persistent changes to the nasal ciliated epithelium following SARS-CoV2 infection: a longitudinal cohort analysis from FOLLOW-COVID Open
Background SARS-CoV2 binds to the respiratory epithelium. Little is known about the recovery and regeneration of the epithelium following COVID-19. Poor recovery could leave individuals at risk of secondary bacterial infection and persiste…
View article: The Neutrophil Granule Protein Olfactomedin-4 Relates to Bronchiectasis Severity and Alters Mucociliary Clearance
The Neutrophil Granule Protein Olfactomedin-4 Relates to Bronchiectasis Severity and Alters Mucociliary Clearance Open
RATIONALE: Bronchiectasis is a chronic respiratory disease characterised by airway infection, inflammation and reduced mucociliary clearance.A previous proteomic study in patients with bronchiectasis revealed olfactomedin-4 (OLFM-4) as a d…
View article: Mutation of CFAP57, a protein required for the asymmetric targeting of a subset of inner dynein arms in Chlamydomonas, causes primary ciliary dyskinesia
Mutation of CFAP57, a protein required for the asymmetric targeting of a subset of inner dynein arms in Chlamydomonas, causes primary ciliary dyskinesia Open
Primary ciliary dyskinesia (PCD) is characterized by chronic airway disease, reduced fertility, and randomization of the left/right body axis. It is caused by defects of motile cilia and sperm flagella. We screened a cohort of affected ind…
View article: Deep phenotyping, including quantitative ciliary beating parameters, and extensive genotyping in primary ciliary dyskinesia
Deep phenotyping, including quantitative ciliary beating parameters, and extensive genotyping in primary ciliary dyskinesia Open
Background Primary ciliary dyskinesia (PCD) is a rare genetic disorder resulting in abnormal ciliary motility/structure, extremely heterogeneous at genetic and ultrastructural levels. We aimed, in light of extensive genotyping, to identify…
View article: Mutation of<i>CFAP57</i>causes primary ciliary dyskinesia by disrupting the asymmetric targeting of a subset of ciliary inner dynein arms
Mutation of<i>CFAP57</i>causes primary ciliary dyskinesia by disrupting the asymmetric targeting of a subset of ciliary inner dynein arms Open
Primary ciliary dyskinesia (PCD) is characterized by chronic airway disease, male infertility, and randomization of the left/right body axis, and is caused by defects of motile cilia and sperm flagella. We screened a cohort of affected ind…
View article: FcRn-Dependent Transcytosis of Monoclonal Antibody in Human Nasal Epithelial Cells In Vitro: A Prerequisite for a New Delivery Route for Therapy?
FcRn-Dependent Transcytosis of Monoclonal Antibody in Human Nasal Epithelial Cells In Vitro: A Prerequisite for a New Delivery Route for Therapy? Open
Monoclonal antibodies (mAbs) are promising therapies to treat airway chronic inflammatory disease (asthma or nasal polyps). To date, no study has specifically assessed, in vitro, the potential function of neonatal Fc receptor (FcRn) in IgG…
View article: How does cilium length affect beating?
How does cilium length affect beating? Open
The effects of cilium length on the dynamics of cilia motion were investigated by high-speed video microscopy of uniciliate mutants of the swimming alga, Chlamydomonas reinhardtii. Cells with short cilia were obtained by deciliating cells …
View article: A new index for characterizing micro-bead motion in a flow induced by ciliary beating: Part I, experimental analysis
A new index for characterizing micro-bead motion in a flow induced by ciliary beating: Part I, experimental analysis Open
Mucociliary clearance is one of the major lines of defense of the respiratory system. The mucus layer coating the pulmonary airways is moved along and out of the lung by the activity of motile cilia, thus expelling the particles trapped in…
View article: A new index for characterizing micro-bead motion in a flow induced by ciliary beating: Part II, modeling
A new index for characterizing micro-bead motion in a flow induced by ciliary beating: Part II, modeling Open
Mucociliary clearance is one of the major lines of defense of the human respiratory system. The mucus layer coating the airways is constantly moved along and out of the lung by the activity of motile cilia, expelling at the same time parti…
View article: Towards the in-vivo automated assessment of nasal cilia mobility
Towards the in-vivo automated assessment of nasal cilia mobility Open
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