Mathieu Coppey
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View article: Single Cells Can Resolve Graded Stimuli
Single Cells Can Resolve Graded Stimuli Open
Cells use signaling pathways as windows into the environment to gather information, transduce it into their interior, and use it to drive behaviors. MAPK (ERK) is a highly conserved signaling pathway in eukaryotes, directing multiple funda…
View article: Live-cell magnetic manipulation of recycling endosomes reveals their direct effect on actin protrusions to promote invasive migration
Live-cell magnetic manipulation of recycling endosomes reveals their direct effect on actin protrusions to promote invasive migration Open
Endocytic recycling pathways play key roles in a broad range of cellular processes, and many vesicle trafficking regulators are implicated in progression of disease such as cancer. The Rab11 family (Rab11a, Rab11b, and Rab25) controls the …
View article: Optogenetic control of a GEF of RhoA uncovers a signaling switch from retraction to protrusion
Optogenetic control of a GEF of RhoA uncovers a signaling switch from retraction to protrusion Open
The ability of a single protein to trigger different functions is an assumed key feature of cell signaling, yet there are very few examples demonstrating it. Here, using an optogenetic tool to control membrane localization of RhoA nucleoti…
View article: Optogenetic control of a GEF of RhoA uncovers a signaling switch from retraction to protrusion
Optogenetic control of a GEF of RhoA uncovers a signaling switch from retraction to protrusion Open
The ability of a single protein to trigger different functions is an assumed key feature of cell signaling, yet there are very few examples demonstrating it. Here, using an optogenetic tool to control membrane localization of RhoA nucleoti…
View article: Control of cell retraction and protrusion with a single protein
Control of cell retraction and protrusion with a single protein Open
Summary The ability of a single protein to trigger different functions is an assumed key feature of cell signaling, yet there are very few examples demonstrating it. Here, using an optogenetic tool to control membrane localization of RhoA …
View article: Live-cell magnetic micromanipulation of recycling endosomes reveals their direct effect on actin-based protrusions to promote invasive migration
Live-cell magnetic micromanipulation of recycling endosomes reveals their direct effect on actin-based protrusions to promote invasive migration Open
Endocytic recycling pathways play key roles in the re-routing of cargoes through the cell to control a broad range of cellular processes, and many vesicle trafficking regulators are implicated in progression of disease such as cancer. The …
View article: Single cells can resolve graded stimuli
Single cells can resolve graded stimuli Open
Cells use signalling pathways as windows into the environment to gather information, transduce it into their interior, and use it to drive behaviours. MAPK (ERK) is a highly conserved signalling pathway in eukaryotes, directing multiple fu…
View article: Biofunctional coating of synthetic magnetic nanoparticles enables magnetogenetic control of protein functions inside cells
Biofunctional coating of synthetic magnetic nanoparticles enables magnetogenetic control of protein functions inside cells Open
Remote control of cellular functions via magnetic forces offers unique opportunities in fundamental research and biomedical application. Intracellular delivery of functionalized magnetic nanoparticles (MNP) provides versatile opportunities…
View article: Single cells can resolve graded stimuli
Single cells can resolve graded stimuli Open
Cells use signalling pathways as windows into the environment to gather information, transduce it into their interior, and use it to drive behaviours. MAPK (ERK) is a highly conserved signalling pathway in eukaryotes, directing multiple fu…
View article: Optogenetic control of a GEF of RhoA uncovers a signaling switch from retraction to protrusion
Optogenetic control of a GEF of RhoA uncovers a signaling switch from retraction to protrusion Open
The ability of a single signaling protein to induce distinct cellular processes is a well-known feature of cell signaling networks. This assumes that proteins can switch their function depending on the cellular context. However, causally p…
View article: Optogenetic control of a GEF of RhoA uncovers a signaling switch from retraction to protrusion
Optogenetic control of a GEF of RhoA uncovers a signaling switch from retraction to protrusion Open
The ability of a single protein to trigger different functions is an assumed key feature of cell signaling, yet there are very few examples demonstrating it. Here, using an optogenetic tool to control membrane localization of RhoA nucleoti…
View article: Author Response: Optogenetic control of a GEF of RhoA uncovers a signaling switch from retraction to protrusion
Author Response: Optogenetic control of a GEF of RhoA uncovers a signaling switch from retraction to protrusion Open
The ability of a single signaling protein to induce distinct cellular processes is a well-known feature of cell signaling networks. This assumes that proteins can switch their function depending on the cellular context. However, causally p…
View article: Reviewer #2 (Public Review): Optogenetic control of a GEF of RhoA uncovers a signaling switch from retraction to protrusion
Reviewer #2 (Public Review): Optogenetic control of a GEF of RhoA uncovers a signaling switch from retraction to protrusion Open
The ability of a single signaling protein to induce distinct cellular processes is a well-known feature of cell signaling networks. This assumes that proteins can switch their function depending on the cellular context. However, causally p…
View article: Reviewer #1 (Public Review): Optogenetic control of a GEF of RhoA uncovers a signaling switch from retraction to protrusion
Reviewer #1 (Public Review): Optogenetic control of a GEF of RhoA uncovers a signaling switch from retraction to protrusion Open
The ability of a single signaling protein to induce distinct cellular processes is a well-known feature of cell signaling networks. This assumes that proteins can switch their function depending on the cellular context. However, causally p…
View article: Optogenetic control of a GEF of RhoA uncovers a signaling switch from retraction to protrusion
Optogenetic control of a GEF of RhoA uncovers a signaling switch from retraction to protrusion Open
Summary The ability of a single protein to trigger different functions is an assumed key feature of cell signaling, yet there are very few examples demonstrating it. Here, using an optogenetic tool to control membrane localization of RhoA …
View article: <scp>RhoA</scp> regulation in space and time
<span>RhoA</span> regulation in space and time Open
RhoGTPases are well known for being controllers of cell cytoskeleton and share common features in the way they act and are controlled. These include their switch from GDP to GTP states, their regulations by different guanine exchange facto…
View article: Directional control of neurite outgrowth: emerging technologies for Parkinson's disease using magnetic nanoparticles and magnetic field gradients
Directional control of neurite outgrowth: emerging technologies for Parkinson's disease using magnetic nanoparticles and magnetic field gradients Open
A challenge in current stem cell therapies for Parkinson's disease (PD) is controlling neuronal outgrowth from the substantia nigra towards the targeted area where connectivity is required in the striatum. Here we present progress towards …
View article: Cell clusters adopt a collective amoeboid mode of migration in confined nonadhesive environments
Cell clusters adopt a collective amoeboid mode of migration in confined nonadhesive environments Open
Cell migration is essential to living organisms and deregulated in cancer. Single cell’s migration ranges from traction-dependent mesenchymal motility to contractility-driven propulsive amoeboid locomotion, but collective cell migration ha…
View article: Synthetic reconstruction of the hunchback promoter specifies the role of Bicoid, Zelda and Hunchback in the dynamics of its transcription
Synthetic reconstruction of the hunchback promoter specifies the role of Bicoid, Zelda and Hunchback in the dynamics of its transcription Open
For over 40 years, the Bicoid- hunchback (Bcd- hb ) system in the fruit fly embryo has been used as a model to study how positional information in morphogen concentration gradients is robustly translated into step-like responses. A body of…
View article: Author response: Synthetic reconstruction of the hunchback promoter specifies the role of Bicoid, Zelda and Hunchback in the dynamics of its transcription
Author response: Synthetic reconstruction of the hunchback promoter specifies the role of Bicoid, Zelda and Hunchback in the dynamics of its transcription Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Appendix 1 Appendix 2 Appendix 3 Appendix 4 Appendix 5 Appendix 6 Data availability References Decision letter Author response Arti…
View article: Autophagy Is Polarized toward Cell Front during Migration and Spatially Perturbed by Oncogenic Ras
Autophagy Is Polarized toward Cell Front during Migration and Spatially Perturbed by Oncogenic Ras Open
Autophagy is a physiological degradation process that removes unnecessary or dysfunctional components of cells. It is important for normal cellular homeostasis and as a response to a variety of stresses, such as nutrient deprivation. Defec…
View article: Synthetic reconstruction of the <i>hunchback</i> promoter specifies the role of Bicoid, Zelda and Hunchback in the dynamics of its transcription
Synthetic reconstruction of the <i>hunchback</i> promoter specifies the role of Bicoid, Zelda and Hunchback in the dynamics of its transcription Open
For over 40 years, the Bicoid-hunchback (Bcd- hb ) system in the fruit fly embryo has been used as the model to study how positional information in morphogen concentration gradients is robustly translated into step-like responses. A body o…
View article: Two timescales control the creation of large protein aggregates in cells
Two timescales control the creation of large protein aggregates in cells Open
Protein aggregation is of particular interest due to its connection with many diseases and disorders. Many factors can alter the dynamics and result of this process, one of them being the diffusivity of the monomers and aggregates in the s…
View article: Persistent cell migration emerges from a coupling between protrusion dynamics and polarized trafficking
Persistent cell migration emerges from a coupling between protrusion dynamics and polarized trafficking Open
Migrating cells present a variety of paths, from random to highly directional ones. While random movement can be explained by basal intrinsic activity, persistent movement requires stable polarization. Here, we quantitatively address emerg…
View article: Parallelized Manipulation of Adherent Living Cells by Magnetic Nanoparticles-Mediated Forces
Parallelized Manipulation of Adherent Living Cells by Magnetic Nanoparticles-Mediated Forces Open
The remote actuation of cellular processes such as migration or neuronal outgrowth is a challenge for future therapeutic applications in regenerative medicine. Among the different methods that have been proposed, the use of magnetic nanopa…
View article: Parallelized manipulation of adherent living cells by magnetic nanoparticles-mediated forces
Parallelized manipulation of adherent living cells by magnetic nanoparticles-mediated forces Open
The remote actuation of cellular processes such as migration or neuronal outgrowth is a challenge for future therapeutic applications in regenerative medicine. Among the different methods that have been proposed, the use of magnetic nanopa…