Mathieu Daynac
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View article: Switching of RNA splicing regulators in immature neuroblasts during adult neurogenesis
Switching of RNA splicing regulators in immature neuroblasts during adult neurogenesis Open
The lateral wall of the mouse subventricular zone harbors neural stem cells (NSC, B cells) which generate proliferating transient-amplifying progenitors (TAP, C cells) that ultimately give rise to neuroblasts (NB, A cells). Molecular profi…
View article: Author response: Switching of RNA splicing regulators in immature neuroblasts during adult neurogenesis
Author response: Switching of RNA splicing regulators in immature neuroblasts during adult neurogenesis Open
View article: Author Response: Switching of RNA splicing regulators in immature neuroblasts: a key step in adult neurogenesis
Author Response: Switching of RNA splicing regulators in immature neuroblasts: a key step in adult neurogenesis Open
The lateral wall of the subventricular zone harbors neural stem cells (NSC, B cells) which generate proliferating transient-amplifying progenitors (TAP, C cells) that ultimately give rise to neuroblasts (NB, A cells). Molecular profiling a…
View article: Switching of RNA splicing regulators in immature neuroblasts: a key step in adult neurogenesis
Switching of RNA splicing regulators in immature neuroblasts: a key step in adult neurogenesis Open
Summary The lateral wall of the subventricular zone harbors neural stem cells (NSC, B cells) which generate proliferating transient-amplifying progenitors (TAP, C cells) that ultimately give rise to neuroblasts (NB, A cells). Molecular pro…
View article: Switching of RNA splicing regulators in immature neuroblasts: a key step in adult neurogenesis
Switching of RNA splicing regulators in immature neuroblasts: a key step in adult neurogenesis Open
Summary The lateral wall of the subventricular zone harbors neural stem cells (NSC, B cells) which generate proliferating transient-amplifying progenitors (TAP, C cells) that ultimately give rise to neuroblasts (NB, A cells). Molecular pro…
View article: Switching of RNA splicing regulators in immature neuroblasts during adult neurogenesis
Switching of RNA splicing regulators in immature neuroblasts during adult neurogenesis Open
The lateral wall of the mouse subventricular zone harbors neural stem cells (NSC, B cells) which generate proliferating transient-amplifying progenitors (TAP, C cells) that ultimately give rise to neuroblasts (NB, A cells). Molecular profi…
View article: Switching of RNA splicing regulators in immature neuroblasts: a key step in adult neurogenesis
Switching of RNA splicing regulators in immature neuroblasts: a key step in adult neurogenesis Open
Summary The lateral wall of the subventricular zone harbors neural stem cells (NSC, B cells) which generate proliferating transient-amplifying progenitors (TAP, C cells) that ultimately give rise to neuroblasts (NB, A cells). Molecular pro…
View article: BRAF/MEK Inhibition Induces Cell State Transitions Boosting Immune Checkpoint Sensitivity in BRAF<sup>V600E</sup>-mutant Glioma
BRAF/MEK Inhibition Induces Cell State Transitions Boosting Immune Checkpoint Sensitivity in BRAF<sup>V600E</sup>-mutant Glioma Open
Resistance to BRAF plus MEK inhibition (BRAFi+MEKi) in BRAF V600E -mutant gliomas drives rebound, progression, and high mortality, yet it remains poorly understood. This study addresses the urgent need to develop treatments for BRAFi+MEKi-…
View article: EXTH-42. COMBINATION OF MAPK PATHWAY INHIBITORS AND IMMUNE CHECKPOINT BLOCKADE IN BRAF-MUTANT HIGH-GRADE GLIOMA
EXTH-42. COMBINATION OF MAPK PATHWAY INHIBITORS AND IMMUNE CHECKPOINT BLOCKADE IN BRAF-MUTANT HIGH-GRADE GLIOMA Open
BACKGROUND Despite successes, clinical MAPK pathway inhibitors show limited anti-tumor activity in the majority of patients with BRAF-mutant high-grade glioma. Because of the presence of higher fraction of CD8+ tumor-infiltrating T cells i…
View article: Dynamic extrinsic pacing of the HOX clock in human axial progenitors controls motor neuron subtype specification
Dynamic extrinsic pacing of the HOX clock in human axial progenitors controls motor neuron subtype specification Open
Rostro-caudal patterning of vertebrates depends on the temporally progressive activation of HOX genes within axial stem cells that fuel axial embryo elongation. Whether the pace of sequential activation of HOX genes, the 'HOX clock', is co…
View article: Sonic Hedgehog receptor Patched deficiency in astrocytes enhances glucose metabolism in mice
Sonic Hedgehog receptor Patched deficiency in astrocytes enhances glucose metabolism in mice Open
Here, we define hypothalamic Shh action on astrocytes as a novel master regulator of energy metabolism. In the hypothalamus, astrocytic Shh signaling could be critically involved in preventing both aging- and obesity-related metabolic diso…
View article: Dynamic extrinsic pacing of the<i>HOX</i>clock in human axial progenitors controls motor neuron subtype specification
Dynamic extrinsic pacing of the<i>HOX</i>clock in human axial progenitors controls motor neuron subtype specification Open
SUMMARY Rostro-caudal patterning of vertebrates depends on the temporally progressive activation of HOX genes within axial stem cells that fuel axial embryo elongation. Whether HOX genes sequential activation, the “ HOX clock”, is paced by…
View article: Lgl1 controls NG2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis
Lgl1 controls NG2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis Open
View article: Distinct Molecular Signatures of Quiescent and Activated Adult Neural Stem Cells Reveal Specific Interactions with Their Microenvironment
Distinct Molecular Signatures of Quiescent and Activated Adult Neural Stem Cells Reveal Specific Interactions with Their Microenvironment Open
Deciphering the mechanisms that regulate the quiescence of adult neural stem cells (NSCs) is crucial for the development of therapeutic strategies based on the stimulation of their endogenous regenerative potential in the damaged brain. We…
View article: STEM-05. THE CONSERVED TUMOR SUPPRESSOR LGL1 REGULATES ADULT OLIGODENDROCYTE PROGENITOR CELL DIVISION MODE AND PREVENTS PREMALIGNANT PHENOTYPES
STEM-05. THE CONSERVED TUMOR SUPPRESSOR LGL1 REGULATES ADULT OLIGODENDROCYTE PROGENITOR CELL DIVISION MODE AND PREVENTS PREMALIGNANT PHENOTYPES Open
Mammalian oligodendrocyte progenitor cells (OPC) divide asymmetrically by dispatching pro-mitotic NG2, EGFR and PDGFRalpha, from here on called the NG2 complex, unequally between daughter cells to establish a cell fate bias and to restrict…
View article: Concurrent MEK targeted therapy prevents MAPK pathway reactivation during BRAFV600E targeted inhibition in a novel syngeneic murine glioma model
Concurrent MEK targeted therapy prevents MAPK pathway reactivation during BRAFV600E targeted inhibition in a novel syngeneic murine glioma model Open
Inhibitors of BRAFV600E kinase are currently under investigations in preclinical and clinical studies involving BRAFV600E glioma. Studies demonstrated clinical response to such individualized therapy in the majority of patients whereas in …
View article: Hedgehog Controls Quiescence and Activation of Neural Stem Cells in the Adult Ventricular-Subventricular Zone
Hedgehog Controls Quiescence and Activation of Neural Stem Cells in the Adult Ventricular-Subventricular Zone Open
Identifying the mechanisms controlling quiescence and activation of neural stem cells (NSCs) is crucial for understanding brain repair. Here, we demonstrate that Hedgehog (Hh) signaling actively regulates different pools of quiescent and p…
View article: Age-related neurogenesis decline in the subventricular zone is associated with specific cell cycle regulation changes in activated neural stem cells
Age-related neurogenesis decline in the subventricular zone is associated with specific cell cycle regulation changes in activated neural stem cells Open
Although neural stem cells (NSCs) sustain continuous neurogenesis throughout the adult lifespan of mammals, they progressively exhibit proliferation defects that contribute to a sharp reduction in subventricular neurogenesis during aging. …
View article: Cell Sorting of Neural Stem and Progenitor Cells from the Adult Mouse Subventricular Zone and Live-imaging of their Cell Cycle Dynamics
Cell Sorting of Neural Stem and Progenitor Cells from the Adult Mouse Subventricular Zone and Live-imaging of their Cell Cycle Dynamics Open
Neural stem cells (NSCs) in the subventricular zone of the lateral ventricles (SVZ) sustain olfactory neurogenesis throughout life in the mammalian brain. They successively generate transit amplifying cells (TACs) and neuroblasts that diff…
View article: Application of Artificial Intelligence to the Prediction of the Antimicrobial Activity of Essential Oils
Application of Artificial Intelligence to the Prediction of the Antimicrobial Activity of Essential Oils Open
Essential oils (EOs) are vastly used as natural antibiotics in Complementary and Alternative Medicine (CAM). Their intrinsic chemical variability and synergisms/antagonisms between its components make difficult to ensure consistent effects…