Mathieu Meode
YOU?
Author Swipe
View article: IGF2 supports glioblastoma growth and immune evasion through a combination of tumor cell-intrinsic and -extrinsic mechanisms
IGF2 supports glioblastoma growth and immune evasion through a combination of tumor cell-intrinsic and -extrinsic mechanisms Open
Background Intra- and inter-tumoral heterogeneity combined with immunosuppressive tumor microenvironments contribute to the poor outcomes associated with glioblastoma (GBM). Well-characterized immunocompetent models that recapitulate human…
View article: 36 ISOLATION OF CANDIDATE GLIOBLASTOMA-INITIATING CELLS FROM MULTIPLE REGIONS OF THE ADULT MAMMALIAN BRAIN USING PLATELET-DERIVED GROWTH FACTOR C
36 ISOLATION OF CANDIDATE GLIOBLASTOMA-INITIATING CELLS FROM MULTIPLE REGIONS OF THE ADULT MAMMALIAN BRAIN USING PLATELET-DERIVED GROWTH FACTOR C Open
Brain Cancer Canada Travel Award Recipient An important observation in neurobiology was the discovery of neural stem cells (NSCs) in the adult mammalian brain by Reynolds and Weiss. Although ‘brain repair’ was the initial thrust of researc…
View article: Isolation of Neural Stem Cells Using Platelet Derived Growth Factor C
Isolation of Neural Stem Cells Using Platelet Derived Growth Factor C Open
Summary Here, we show that Platelet-Derived Growth Factor C (PDGFC) supports the isolation of neural stem cells (NSCs) from the murine subventricular zone (SVZ) and maintains them in quiescent and slowly proliferating states. We also show …
View article: TMOD-01. EGFR AMPLIFICATION ACCOMPANIES ADAPTATION TO MITOGEN-INDUCED DEFECTIVE MITOSIS IN PDGFA
TMOD-01. EGFR AMPLIFICATION ACCOMPANIES ADAPTATION TO MITOGEN-INDUCED DEFECTIVE MITOSIS IN PDGFA Open
Using a newly described in vitro murine model of GBM [Bohm et al., Neuro-Oncol 2020 and Omairi et al., Neuro-Oncol 2023] in which P53 null neural progenitor cells (NPCs) divide abnormally and evolve a GBM-like genome during exposure to Pla…
View article: IMMU-36. MULTI-OMIC CHARACTERIZATION OF A SYNGENEIC MOUSE CANCER STEM CELL MODEL OF GBM FOR PRECLINICAL APPLICATIONS
IMMU-36. MULTI-OMIC CHARACTERIZATION OF A SYNGENEIC MOUSE CANCER STEM CELL MODEL OF GBM FOR PRECLINICAL APPLICATIONS Open
Glioblastoma (GBM) is resistant to many therapies including immunotherapies. There is an urgent need to explore the role of the microenvironment in resistance to therapy with tailored pre-clinical models. Using multi-omic approaches we des…
View article: Mitogen-induced defective mitosis transforms neural progenitor cells
Mitogen-induced defective mitosis transforms neural progenitor cells Open
Background Chromosome instability (CIN) with recurrent copy number alterations is a feature of many solid tumors, including glioblastoma (GBM), yet the genes that regulate cell division are rarely mutated in cancers. Here, we show that the…
View article: PDGF gene expression and p53 alterations contribute to the biology of diffuse astrocytic gliomas
PDGF gene expression and p53 alterations contribute to the biology of diffuse astrocytic gliomas Open
Diffuse, histologically lower grade astrocytomas of adults (LGAs) are classified based on the mutational status of the isocitrate dehydrogenase ( IDH ) genes. While wild-type (WT) LGAs often evolve quickly to glioblastoma (GBM), mutant tum…