Mathieu Moreau
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View article: Ultra-hypofractionated radiotherapy with focal boost for high-risk localized prostate cancer (HYPO-RT-PC-boost): in silico evaluation with histological reference
Ultra-hypofractionated radiotherapy with focal boost for high-risk localized prostate cancer (HYPO-RT-PC-boost): in silico evaluation with histological reference Open
Background and purpose: The study aims to evaluate dosimetric properties of hypofractionated treatment plans integrating focal boost, using registered whole-mount histopathology (WMHP) as reference standard. Methods: Fifteen men from the P…
View article: Impact of deep learning model uncertainty on manual corrections to MRI‐based auto‐segmentation in prostate cancer radiotherapy
Impact of deep learning model uncertainty on manual corrections to MRI‐based auto‐segmentation in prostate cancer radiotherapy Open
Background Deep learning (DL)‐based organ segmentation is increasingly used in radiotherapy. While methods exist to generate voxel‐wise uncertainty maps from DL‐based auto‐segmentation models, these maps are rarely presented to clinicians.…
View article: Versatile Bifunctional PYTA Derivatives for <sup>225</sup> Ac Radiolabeling: A Comparison to Gold Standards
Versatile Bifunctional PYTA Derivatives for <sup>225</sup> Ac Radiolabeling: A Comparison to Gold Standards Open
We report the synthesis and evaluation of the first 3,6,10,13-tetraaza-1,8(2,6)-dipyridinacyclotetradecaphane-3,6,10,13-tetraacetic acid (PYTA) bifunctional chelators (BFCs) for 225Ac coordination. Methods: Three PYTA BFCs (PYTA-triacetate…
View article: Versatile bifunctional PYTA derivatives for actinium-225 radiolabeling: a comparison to gold standards
Versatile bifunctional PYTA derivatives for actinium-225 radiolabeling: a comparison to gold standards Open
We report the synthesis and evaluation of the first PYTA bifunctional chelators (BFCs) designed for actinium-225 coordination. Methods: Three PYTA bifunctional chelators, PY3A, PYTA-GA, and PYTA-PE, were synthesized. A comparative radiolab…
View article: Abstract 1825: Pharmacological evaluation of bioconjugated trastuzumab using the AbYlinkTM regio-selective conjugation technology in gastric cancer expressing HER2+
Abstract 1825: Pharmacological evaluation of bioconjugated trastuzumab using the AbYlinkTM regio-selective conjugation technology in gastric cancer expressing HER2+ Open
Purpose/introduction: Bioconjugation is a critical step in the development of Antibody Drug Conjugates with two main strategies dominating the field. One approach employs covalent chemistry to randomly bind a drug to the accessible Lysines…
View article: Impact of deep learning model uncertainty on manual corrections to auto-segmentation in prostate cancer radiotherapy
Impact of deep learning model uncertainty on manual corrections to auto-segmentation in prostate cancer radiotherapy Open
Background: Deep learning (DL)-based organ segmentation is increasingly used in radiotherapy, yet voxel-wise DL uncertainty maps are rarely presented to clinicians. Purpose: This study assessed how DL-generated uncertainty maps impact radi…
View article: Versatile bifunctional PYTA derivatives for actinium-225 radiolabeling: a comparison to gold standards
Versatile bifunctional PYTA derivatives for actinium-225 radiolabeling: a comparison to gold standards Open
We report the synthesis of the first PYTA bifunctional chelators designed for the coordination of actinium-225 and their bioconjugation to biovectors of interest. Three PYTA bifunctional chelators, PY3A, PYTA-GA, and PYTA-PE, were synthesi…
View article: LUND-PROBE -- LUND Prostate Radiotherapy Open Benchmarking and Evaluation dataset
LUND-PROBE -- LUND Prostate Radiotherapy Open Benchmarking and Evaluation dataset Open
Radiotherapy treatment for prostate cancer relies on computed tomography (CT) and/or magnetic resonance imaging (MRI) for segmentation of target volumes and organs at risk (OARs). Manual segmentation of these volumes is regarded as the gol…
View article: Collagen-targeted PET imaging for progressive experimental lung fibrosis quantification and monitoring of efficacy of anti-fibrotic therapies
Collagen-targeted PET imaging for progressive experimental lung fibrosis quantification and monitoring of efficacy of anti-fibrotic therapies Open
Idiopathic pulmonary fibrosis (IPF) is a progressive disease characterized by an excessive collagen deposition ultimately leading to tissue stiffening and functional decline. Beyond IPF, other progressive pulmonary fibrosis are often assoc…
View article: Targeted radionuclide therapy against GARP expressing T regulatory cells after tumour priming with external beam radiotherapy in a murine syngeneic model
Targeted radionuclide therapy against GARP expressing T regulatory cells after tumour priming with external beam radiotherapy in a murine syngeneic model Open
This theranostic strategy may allow for the personalization of cancer treatments by early detection of activated Tregs infiltration following RT and identification of patients likely to respond to Tregs-targeted therapy via TRT.
View article: Histopathology-validated gross tumor volume delineations of intraprostatic lesions using PSMA-positron emission tomography/multiparametric magnetic resonance imaging
Histopathology-validated gross tumor volume delineations of intraprostatic lesions using PSMA-positron emission tomography/multiparametric magnetic resonance imaging Open
The combined use of mpMRI or PSMA-PET/mpMRI shows promise, achieving higher DSC and lesion coverage while minimizing non-malignant tissue inclusion, in comparison to the use of a single image type with an added CTV margin.
View article: Accuracy of gross tumour volume delineation with [68Ga]-PSMA-PET compared to histopathology for high-risk prostate cancer
Accuracy of gross tumour volume delineation with [68Ga]-PSMA-PET compared to histopathology for high-risk prostate cancer Open
Background: The delineation of intraprostatic lesions is vital for correct delivery of focal radiotherapy boost in patients with prostate cancer (PC). Errors in the delineation could translate into reduced tumour control and potentially in…
View article: Moving Beyond Isothiocyanates: A Look at the Stability of Conjugation Links Toward Radiolysis in <sup>89</sup>Zr-Labeled Immunoconjugates
Moving Beyond Isothiocyanates: A Look at the Stability of Conjugation Links Toward Radiolysis in <sup>89</sup>Zr-Labeled Immunoconjugates Open
Zirconium-89 is the most widely used radioisotope for immunoPET because its physical half-life (78.2 h) suits the one of antibodies. Desferrioxamine B (DFO) is the standard chelator for the complexation of zirconium(IV), and its bifunction…
View article: SPECT Imaging of Lysyl Oxidase-like 2 in a Model of Idiopathic Pulmonary Fibrosis
SPECT Imaging of Lysyl Oxidase-like 2 in a Model of Idiopathic Pulmonary Fibrosis Open
Noninvasive imaging of idiopathic pulmonary fibrosis (IPF) remains a challenge. The aim of this study was to develop an antibody-based radiotracer targeting Lysyl Oxidase-like 2 (LOXL2), an enzyme involved in the fibrogenesis process, for …
View article: Site-Specific, Platform-Based Conjugation Strategy for the Synthesis of Dual-Labeled Immunoconjugates for Bimodal PET/NIRF Imaging of HER2-Positive Tumors
Site-Specific, Platform-Based Conjugation Strategy for the Synthesis of Dual-Labeled Immunoconjugates for Bimodal PET/NIRF Imaging of HER2-Positive Tumors Open
Because positron emission tomography (PET) and optical imaging are very complementary, the combination of these two imaging modalities is very enticing in the oncology field. Such bimodal imaging generally relies on imaging agents bearing …
View article: Cultural adaptation of a community‐based advance serious illness planning decision aid to the Quebec context involving end‐users
Cultural adaptation of a community‐based advance serious illness planning decision aid to the Quebec context involving end‐users Open
Introduction Traditional advance care planning focuses on end‐of‐life planning in the context of a certain or imminent death. It is not tailored for serious illness planning, where the ‘death’ outcome is uncertain. The Plan Well Guide™ (PW…
View article: Titanate nanoribbon-based nanobiohybrid for potential applications in regenerative medicine
Titanate nanoribbon-based nanobiohybrid for potential applications in regenerative medicine Open
Titanate nanoribbons functionalized by heterobifunctional polymer and type I collagen for cellular adhesion and proliferation. This new nanobiohybrid affected neither cytotoxicity nor platelet aggregation ability.
View article: Determining Factors Influencing RAS Inhibitors Re-Initiation in ICU: A Modified Delphi Method
Determining Factors Influencing RAS Inhibitors Re-Initiation in ICU: A Modified Delphi Method Open
Background: Renin-angiotensin system inhibitors (RASi) are not re-initiated for almost a quarter of patients who suffered acute kidney injury 6 months after discharge. This discontinuation might be partly explained by the nephrotoxicity of…
View article: The GRP94 Inhibitor PU-WS13 Decreases M2-like Macrophages in Murine TNBC Tumors: A Pharmaco-Imaging Study with 99mTc-Tilmanocept SPECT
The GRP94 Inhibitor PU-WS13 Decreases M2-like Macrophages in Murine TNBC Tumors: A Pharmaco-Imaging Study with 99mTc-Tilmanocept SPECT Open
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancers and is not eligible for hormone and anti-HER2 therapies. Identifying therapeutic targets and associated biomarkers in TNBC is a clinical challenge to imp…
View article: Positron Emission Tomography Imaging of Neurotensin Receptor-Positive Tumors with <sup>68</sup>Ga-Labeled Antagonists: The Chelate Makes the Difference Again
Positron Emission Tomography Imaging of Neurotensin Receptor-Positive Tumors with <sup>68</sup>Ga-Labeled Antagonists: The Chelate Makes the Difference Again Open
Neurotensin receptor 1 (NTS1) is involved in the development and progression of numerous cancers, which makes it an interesting target for the development of diagnostic and therapeutic agents. A small molecule NTS1 antagonist, named [177Lu…
View article: [18F]FMISO PET/CT imaging of hypoxia as a non-invasive biomarker of disease progression and therapy efficacy in a preclinical model of pulmonary fibrosis: comparison with the [18F]FDG PET/CT approach
[18F]FMISO PET/CT imaging of hypoxia as a non-invasive biomarker of disease progression and therapy efficacy in a preclinical model of pulmonary fibrosis: comparison with the [18F]FDG PET/CT approach Open
Purpose Idiopathic pulmonary fibrosis (IPF) is a progressive disease with poor outcome and limited therapeutic options. Imaging of IPF is limited to high-resolution computed tomography (HRCT) which is often not sufficient for a definite di…
View article: Nanofitins targeting heat shock protein 110: An innovative immunotherapeutic modality in cancer
Nanofitins targeting heat shock protein 110: An innovative immunotherapeutic modality in cancer Open
The presence of an inactivating heat shock protein 110 (HSP110) mutation in colorectal cancers has been correlated with an excellent prognosis and with the ability of HSP110 to favor the formation of tolerogenic (M2‐like) macrophages. Thes…
View article: Lipoproteins LDL versus HDL as nanocarriers to target either cancer cells or macrophages
Lipoproteins LDL versus HDL as nanocarriers to target either cancer cells or macrophages Open
In this work, we have explored natural unmodified low- and high-density lipoproteins (LDL and HDL, respectively) as selective delivery vectors in colorectal cancer therapy. We show in vitro in cultured cells and in vivo (NanoSPECT/CT) in t…
View article: Data for: Synthesis and evaluation of 89Zr-labeled and long-lived GLP-1 receptor agonists for PET imaging
Data for: Synthesis and evaluation of 89Zr-labeled and long-lived GLP-1 receptor agonists for PET imaging Open
Appendix B. PET imaging 3D rendered images. 1. PET 3D of 4-89Zr 2. PET 3D of 5-89Zr
View article: Titanate Nanotubes Engineered with Gold Nanoparticles and Docetaxel to Enhance Radiotherapy on Xenografted Prostate Tumors
Titanate Nanotubes Engineered with Gold Nanoparticles and Docetaxel to Enhance Radiotherapy on Xenografted Prostate Tumors Open
Nanohybrids based on titanate nanotubes (TiONts) were developed to fight prostate cancer by intratumoral (IT) injection, and particular attention was paid to their step-by-step synthesis. TiONts were synthesized by a hydrothermal process. …