Mathieu Pernot
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View article: Revisiting the concept of “phenotype” in pediatric hypertrophic cardiomyopathy using myocardial stiffness and strain variations assessed by ultrafast ultrasound imaging
Revisiting the concept of “phenotype” in pediatric hypertrophic cardiomyopathy using myocardial stiffness and strain variations assessed by ultrafast ultrasound imaging Open
Background Pediatric hypertrophic cardiomyopathy (HCM) is associated with significant morbidity and mortality. While identified as a genetic disease mainly involving sarcomeric genes, the association between genotypical variation and pheno…
View article: Multi-lens ultrasound arrays enable large scale three-dimensional micro-vascularization characterization over whole organs
Multi-lens ultrasound arrays enable large scale three-dimensional micro-vascularization characterization over whole organs Open
Mapping microcirculation at the whole-organ scale in 3D is crucial for understanding vascular pathologies and improving diagnostics. Although 3D ultrasound localization microscopy (ULM) enables microscopic resolution by localizing intraven…
View article: In vivo microvascular flow quantification in the mouse brain using Row-Column Ultrasound Localization Microscopy and directed graph analysis
In vivo microvascular flow quantification in the mouse brain using Row-Column Ultrasound Localization Microscopy and directed graph analysis Open
Brain perfusion relies on a complex vascular network of arteries, veins, and capillaries to meet its constant demand for oxygen and nutrients. Disruption of this microvascular system is a hallmark of many neurological disorders, including …
View article: Short- and Long-Term Effects of Pulsed Ultrasound Cavitation Therapy of Calcified Valvular Interstitial Cells in Culture
Short- and Long-Term Effects of Pulsed Ultrasound Cavitation Therapy of Calcified Valvular Interstitial Cells in Culture Open
These studies suggest that ultrasound therapy, currently limited to very severe aortic stenosis, could be of interest at an earlier stage of the disease.
View article: Harmonic Amplitude-Modulated Singular Value Decomposition for Ultrafast Ultrasound Imaging of Gas Vesicles
Harmonic Amplitude-Modulated Singular Value Decomposition for Ultrafast Ultrasound Imaging of Gas Vesicles Open
Ultrafast nonlinear ultrasound imaging of gas vesicles (GV) contrast agents promises high-sensitivity biomolecular visualization with applications such as targeted molecular imaging of tumor markers or real-time tracking of gene expression…
View article: Centrifugation versus filtration-based cell salvage: impact on perioperative bleeding in cardiac surgery—the COLTRANE randomised clinical trial – study protocol
Centrifugation versus filtration-based cell salvage: impact on perioperative bleeding in cardiac surgery—the COLTRANE randomised clinical trial – study protocol Open
Introduction Cardiac surgery remains a high-risk procedure for bleeding despite advances in patient blood management. Conventional centrifugation-based autotransfusion devices primarily recover red blood cells, losing platelets and coagula…
View article: Volumetric axial velocity estimation with XDoppler using row-column arrays
Volumetric axial velocity estimation with XDoppler using row-column arrays Open
Accurate volumetric velocity estimation in ultrasound imaging is crucial for both diagnostic and therapeutic applications. Traditional ultrasound systems, though effective for two-dimensional imaging, face major limitations in 3D imaging d…
View article: In-vivo muscle characterization by 3D Elastic and Backscatter Tensor Imaging using a low channel count system
In-vivo muscle characterization by 3D Elastic and Backscatter Tensor Imaging using a low channel count system Open
Over the last decade, 3D ultrafast ultrasound imaging has been used in different applications including Elastic Tensor Imaging (ETI) based on 3D Shear Wave Elastography and Backscatter Tensor Imaging (BTI). BTI and ETI can provide importan…
View article: Assessment of microvascular flow in human atherosclerotic carotid plaques using ultrasound localization microscopy
Assessment of microvascular flow in human atherosclerotic carotid plaques using ultrasound localization microscopy Open
The study was sponsored and funded by Assistance Publique-Hôpitaux de Paris (CRC 1806 APHP INNOVATION 2018). Co-funding by ART (Technological Research Accelerator) biomedical ultrasound program of INSERM, France.
View article: Non-Invasive Ultrasound Therapy for Severe Aortic Stenosis: Early Effects on the Valve, Ventricle, and Cardiac Biomarkers (A Case Series)
Non-Invasive Ultrasound Therapy for Severe Aortic Stenosis: Early Effects on the Valve, Ventricle, and Cardiac Biomarkers (A Case Series) Open
Background: Transcatheter aortic valve replacement (TAVR) was developed for inoperable patients with severe aortic stenosis. However, despite TAVR advancements, some patients remain untreated due to complex comorbidities, necessitating les…
View article: Rationale and design of the PACIFIC-PRESERVED (PhenomApping, ClassIFication and Innovation for Cardiac dysfunction in patients with heart failure and PRESERVED left ventricular ejection fraction) study
Rationale and design of the PACIFIC-PRESERVED (PhenomApping, ClassIFication and Innovation for Cardiac dysfunction in patients with heart failure and PRESERVED left ventricular ejection fraction) study Open
Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome that is poorly defined, reflecting an incomplete understanding of its pathophysiology.
View article: Assessment of Thoracic Endovascular Aortic Repair Using Relay Proximal Scallop: Results of a French Prospective Multicentre Study
Assessment of Thoracic Endovascular Aortic Repair Using Relay Proximal Scallop: Results of a French Prospective Multicentre Study Open
View article: High sensitivity mapping of brain-wide functional networks in awake mice using simultaneous multi-slice fUS imaging
High sensitivity mapping of brain-wide functional networks in awake mice using simultaneous multi-slice fUS imaging Open
Functional ultrasound (fUS) has received growing attention in preclinical research in the past decade, providing a new tool to measure functional connectivity (FC) and brain task-evoked responses with single-trial detection capability in b…
View article: The fundamental mechanisms of the Korotkoff sounds generation
The fundamental mechanisms of the Korotkoff sounds generation Open
Blood pressure measurement is the most widely performed clinical exam to predict mortality risk. The gold standard for its noninvasive assessment is the auscultatory method, which relies on listening to the so-called “Korotkoff sounds” in …
View article: Assessment of coronary microcirculation alterations in a porcine model of no-reflow using ultrasound localization microscopy: a proof of concept study
Assessment of coronary microcirculation alterations in a porcine model of no-reflow using ultrasound localization microscopy: a proof of concept study Open
View article: Assessment of Takayasu's arteritis activity by ultrasound localization microscopy
Assessment of Takayasu's arteritis activity by ultrasound localization microscopy Open
View article: Methods: Aortic wall deformation assessment by ultrafast ultrasound imaging: Application to bicuspid aortic valve associated aortopathy
Methods: Aortic wall deformation assessment by ultrafast ultrasound imaging: Application to bicuspid aortic valve associated aortopathy Open
Purpose: Aortic maximal rate of systolic distention (MRSD) is a prognosis factor of ascending aorta dilatation with magnetic resonance imaging. Its calculation requires precise continuous tracking of the aortic diameter over the cardiac cy…
View article: Transcranial 3D ultrasound localization microscopy using a large element matrix array with a multi-lens diffracting layer: an <i>in vitro</i> study
Transcranial 3D ultrasound localization microscopy using a large element matrix array with a multi-lens diffracting layer: an <i>in vitro</i> study Open
Objective . Early diagnosis and acute knowledge of cerebral disease require to map the microflows of the whole brain. Recently, ultrasound localization microscopy (ULM) was applied to map and quantify blood microflows in 2D in the brain of…
View article: Evaluation of Takayasu's arteritis activity by ultrasound localization microscopy
Evaluation of Takayasu's arteritis activity by ultrasound localization microscopy Open
Objectives Use of sulphur hexafluoride microbubbles (MB) with ultrasound can provide arterial wall enhancement. The use of ultrafast imaging with MB super-localization offers the possibility of ultrasound localization microscopy (ULM) and …
View article: Quantitative stiffness assessment of cardiac grafts using ultrasound in a porcine model: A tissue biomarker for heart transplantation
Quantitative stiffness assessment of cardiac grafts using ultrasound in a porcine model: A tissue biomarker for heart transplantation Open
FRM PME20170637799, Agence Biomédecine AOR Greffe 2017, ANR-18-CE18-0015.
View article: In vivo whole brain microvascular imaging in mice using transcranial 3D Ultrasound Localization Microscopy
In vivo whole brain microvascular imaging in mice using transcranial 3D Ultrasound Localization Microscopy Open
View article: Coronary Flow Assessment Using 3-Dimensional Ultrafast Ultrasound Localization Microscopy
Coronary Flow Assessment Using 3-Dimensional Ultrafast Ultrasound Localization Microscopy Open
View article: Comparison of Surgical Ventricular Septal Reduction to Alcohol Septal Ablation Therapy in Patients with Hypertrophic Cardiomyopathy
Comparison of Surgical Ventricular Septal Reduction to Alcohol Septal Ablation Therapy in Patients with Hypertrophic Cardiomyopathy Open
View article: Boosting transducer matrix sensitivity for 3D large field ultrasound localization microscopy using a multi-lens diffracting layer: a simulation study
Boosting transducer matrix sensitivity for 3D large field ultrasound localization microscopy using a multi-lens diffracting layer: a simulation study Open
Mapping blood microflows of the whole brain is crucial for early diagnosis of cerebral diseases. Ultrasound localization microscopy (ULM) was recently applied to map and quantify blood microflows in 2D in the brain of adult patients down t…
View article: Percutaneous Total Aortic Arch Repair With In Situ Laser Fenestration
Percutaneous Total Aortic Arch Repair With In Situ Laser Fenestration Open
View article: Volumetric ultrasound localization microscopy of the whole brain microvasculature
Volumetric ultrasound localization microscopy of the whole brain microvasculature Open
Technologies to visualize whole organs across scales in vivo are essential for our understanding of biology in health and disease. To date, only post-mortem techniques achieve cellular resolution across entire organs. 2D ultrasound localiz…
View article: A guide for assessment of myocardial stiffness in health and disease
A guide for assessment of myocardial stiffness in health and disease Open
View article: Decrease of Pdzrn3 is required for heart maturation and protects against heart failure
Decrease of Pdzrn3 is required for heart maturation and protects against heart failure Open
View article: Volumetric Ultrasound Localization Microscopy of the Whole Rat Brain Microvasculature
Volumetric Ultrasound Localization Microscopy of the Whole Rat Brain Microvasculature Open
Technologies to visualize whole organs across scales in vivo are essential for our understanding of biology in health and disease. To date, only post-mortem techniques achieve cellular resolution across entire organs. Here, we demonstrate …
View article: Assessing cardiac stiffness using ultrasound shear wave elastography
Assessing cardiac stiffness using ultrasound shear wave elastography Open
Shear wave elastography offers a new dimension to echocardiography: it measures myocardial stiffness. Therefore, it could provide additional insights into the pathophysiology of cardiac diseases affecting myocardial stiffness and potential…