Mathieu Repellin
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View article: Nanoparticle delivery of AMPK activator 991 prevents its toxicity and improves muscle homeostasis in Duchenne muscular dystrophy
Nanoparticle delivery of AMPK activator 991 prevents its toxicity and improves muscle homeostasis in Duchenne muscular dystrophy Open
Muscular dystrophies, such as Duchenne muscular dystrophy (DMD), are caused by permanent muscle injuries leading to chronic inflammation, with macrophages harboring an altered inflammatory profile contributing to fibrosis through the secre…
View article: Biomimetic hybrid vesicles for colorectal cancer targeting
Biomimetic hybrid vesicles for colorectal cancer targeting Open
International audience
View article: Drug-loaded nanoparticles induce immunogenic cell death and efficiently target cells from glioblastoma patients
Drug-loaded nanoparticles induce immunogenic cell death and efficiently target cells from glioblastoma patients Open
Our findings suggest that DACHPt-loaded NPs represent a promising therapeutic strategy capable of targeting both tumor cells and tumor-promoting immune cells while inducing ICD.
View article: Physical, biochemical, and biological characterization of olive-derived lipid nanovesicles for drug delivery applications
Physical, biochemical, and biological characterization of olive-derived lipid nanovesicles for drug delivery applications Open
View article: ROS-based nanomedicines for anti-inflammatory therapies
ROS-based nanomedicines for anti-inflammatory therapies Open
Graphical abstract Abstract Reactive oxygen species (ROS) are important signaling molecules that play key roles in the progression of inflammatory disorders. Owing to a mismatch of the antioxidant level to balance the overproduction of ROS…
View article: Hybrid core-shell particles for mRNA systemic delivery
Hybrid core-shell particles for mRNA systemic delivery Open
View article: Drug delivery nanosystems for skeletal muscle treatment in myotonic dystrophy
Drug delivery nanosystems for skeletal muscle treatment in myotonic dystrophy Open
View article: Nanomedicine for Gene Delivery and Drug Repurposing in the Treatment of Muscular Dystrophies
Nanomedicine for Gene Delivery and Drug Repurposing in the Treatment of Muscular Dystrophies Open
Muscular Dystrophies (MDs) are a group of rare inherited genetic muscular pathologies encompassing a variety of clinical phenotypes, gene mutations and mechanisms of disease. MDs undergo progressive skeletal muscle degeneration causing sev…
View article: Alcian blue staining to track the intracellular fate of hyaluronic-acid-based nanoparticles at transmission electron microscopy
Alcian blue staining to track the intracellular fate of hyaluronic-acid-based nanoparticles at transmission electron microscopy Open
The main step in the assessment of nanomaterial safety and suitability for biomedical use is the location and the dynamic tracking of nanoparticles (NPs) inside cells or tissues. To precisely investigate the uptake mechanisms and intracell…