Mathieu Seynaeve
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View article: 5‐Methoxy‐ <i>N</i> , <i>N</i> ‐dimethyltryptamine (5‐MeO‐DMT) for alcohol use disorder: An open‐label, phase 2, proof‐of‐concept, clinical trial
5‐Methoxy‐ <i>N</i> , <i>N</i> ‐dimethyltryptamine (5‐MeO‐DMT) for alcohol use disorder: An open‐label, phase 2, proof‐of‐concept, clinical trial Open
Background and Aims Psychedelic drugs may help treat alcohol use disorder (AUD). This study evaluated BPL‐003, a novel intranasal powder formulation of 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) benzoate salt, in people with moderate–sev…
View article: Mapping the phenomenology of intranasal 5-MeO-DMT in psychedelic-naïve healthy adults
Mapping the phenomenology of intranasal 5-MeO-DMT in psychedelic-naïve healthy adults Open
5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a naturally occurring psychedelic tryptamine. Plants containing 5-MeO-DMT have been used throughout history, and in recent years both synthetic and toad-derived 5-MeO-DMT use is being increas…
View article: Low‐dose psilocybin in short‐lasting unilateral neuralgiform headache attacks: results from an open‐label phase Ib ascending dose study
Low‐dose psilocybin in short‐lasting unilateral neuralgiform headache attacks: results from an open‐label phase Ib ascending dose study Open
Background Short‐lasting unilateral neuralgiform headache attacks (SUNHA) are trigeminal autonomic cephalalgias that feature intense and recurrent paroxysms of pain and autonomic symptoms. Many patients are left with debilitating symptoms …
View article: Phase 1, placebo-controlled, single ascending dose trial to evaluate the safety, pharmacokinetics and effect on altered states of consciousness of intranasal BPL-003 (5-methoxy-<i>N,N</i>-dimethyltryptamine benzoate) in healthy participants
Phase 1, placebo-controlled, single ascending dose trial to evaluate the safety, pharmacokinetics and effect on altered states of consciousness of intranasal BPL-003 (5-methoxy-<i>N,N</i>-dimethyltryptamine benzoate) in healthy participants Open
Aims: To investigate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of BPL-003, a novel intranasal benzoate salt formulation of 5-methoxy- N,N-dimethyltryptamine (5-MeO-DMT), in healthy participants. Methods: In …
View article: Klassieke psychedelica: veiligheid, neveneffecten en medicatie-interacties
Klassieke psychedelica: veiligheid, neveneffecten en medicatie-interacties Open
Classic psychedelics: safety, side effects and medication interactions Given the growing scientific and social interest in the use of classic psychedelics for psychiatric disorders, physicians are increasingly confronted with patients reso…
View article: Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression
Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression Open
In this phase 2 trial involving participants with treatment-resistant depression, psilocybin at a single dose of 25 mg, but not 10 mg, reduced depression scores significantly more than a 1-mg dose over a period of 3 weeks but was associate…
View article: Perspectives on psychedelic treatment and research in eating disorders: a web-based questionnaire study of people with eating disorders
Perspectives on psychedelic treatment and research in eating disorders: a web-based questionnaire study of people with eating disorders Open
Approximately 1.25 million people in the UK suffer from an eating disorder, yet the treatment options show limited efficacy, warranting the need for novel approaches. This study aimed to investigate the perspectives of people with eating d…
View article: International online survey of 1048 individuals with functional neurological disorder
International online survey of 1048 individuals with functional neurological disorder Open
Background and purpose Functional neurological disorder (FND) is common, and symptoms can be severe. There have been no international large‐scale studies of patient experiences of FND. Methods A patient questionnaire was created to assess …
View article: Clinical factors associated with progression to dementia in people with late‐life depression: A cohort study of patients in secondary care
Clinical factors associated with progression to dementia in people with late‐life depression: A cohort study of patients in secondary care Open
Background Depression in later life is increasingly being recognised as a prodrome for the development of dementia. We aimed to investigate which clinical factors are associated with more rapid conversion from depression to dementia. Metho…
View article: Clinical factors associated with progression to dementia in people with late-life depression: a cohort study of patients in secondary care
Clinical factors associated with progression to dementia in people with late-life depression: a cohort study of patients in secondary care Open
Objectives Depression can be a prodromal feature or a risk factor for dementia. We aimed to investigate which clinical factors in patients with late-life depression are associated with a higher risk of developing dementia and a more rapid …
View article: Psychedelic treatment of functional neurological disorder: a systematic review
Psychedelic treatment of functional neurological disorder: a systematic review Open
Functional neurological disorder (FND), formerly known as conversion disorder, causes a high burden of disability and distress, and is amongst the most commonly encountered conditions in neurology clinics and neuropsychiatric services, yet…