Mathijs A. Sanders
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View article: Table S1 from A Single-Cell Taxonomy Predicts Inflammatory Niche Remodeling to Drive Tissue Failure and Outcome in Human AML
Table S1 from A Single-Cell Taxonomy Predicts Inflammatory Niche Remodeling to Drive Tissue Failure and Outcome in Human AML Open
Table S1 patient characteristics
View article: Table S3 from A Single-Cell Taxonomy Predicts Inflammatory Niche Remodeling to Drive Tissue Failure and Outcome in Human AML
Table S3 from A Single-Cell Taxonomy Predicts Inflammatory Niche Remodeling to Drive Tissue Failure and Outcome in Human AML Open
Supplementary Table 3. Differentially expressed genes in the NBM BMSC cluster 0 vs. other BMSC clusters
View article: Table S7 from A Single-Cell Taxonomy Predicts Inflammatory Niche Remodeling to Drive Tissue Failure and Outcome in Human AML
Table S7 from A Single-Cell Taxonomy Predicts Inflammatory Niche Remodeling to Drive Tissue Failure and Outcome in Human AML Open
Table S7 Gene list reflecting the inflammatory remodeling of stromal niches in AML
View article: Distinct Roles of <i>Atf3</i> , <i>Zfp711</i> , and <i>Bcl6b</i> in Early Embryonic Hematopoietic and Endothelial Lineage Specification
Distinct Roles of <i>Atf3</i> , <i>Zfp711</i> , and <i>Bcl6b</i> in Early Embryonic Hematopoietic and Endothelial Lineage Specification Open
Hematopoiesis occurs in three consecutive overlapping waves in mammals, regulated by transcription factors. We investigated the role of three relatively poorly studied transcription factors in early embryonic hematopoietic development at s…
View article: Transcriptional profiling directs the classification of acute leukemias of ambiguous lineage into AML, B‐ALL, or T‐ALL
Transcriptional profiling directs the classification of acute leukemias of ambiguous lineage into AML, B‐ALL, or T‐ALL Open
Acute leukemia of ambiguous lineage (ALAL) is a rare, poor‐prognosis acute leukemia subtype that cannot be assigned to a single hematopoietic lineage. Although ALAL patients are typically treated with acute myeloid leukemia (AML) or acute …
View article: 11P Interaction between TILs and body mass index in early HER2+ BC patients: Analysis of the ShortHER trial
11P Interaction between TILs and body mass index in early HER2+ BC patients: Analysis of the ShortHER trial Open
View article: Hematological phenotypes in GATA2 deficiency syndrome arise from aging, maladaptation to proliferation, and somatic events
Hematological phenotypes in GATA2 deficiency syndrome arise from aging, maladaptation to proliferation, and somatic events Open
The GATA2 transcription factor is a pivotal regulator of hematopoiesis. Disruptions in the GATA2 gene drive severe hematologic abnormalities and are associated with an increased risk of myelodysplastic syndromes and acute myeloid leukemia;…
View article: Single-Cell Roadmap of Early Hemato-Endothelial Development: Functions of Atf3, Zfp711 and Bcl6b
Single-Cell Roadmap of Early Hemato-Endothelial Development: Functions of Atf3, Zfp711 and Bcl6b Open
Hematopoiesis is the process of producing blood cells. In mammalian embryos, hematopoiesis occurs in three consecutive overlapping waves (Neo et al. 2021; Dzierzak and Bigas 2018) that are regulated by transcription factors (TFs) and signa…
View article: Single-cell DNA sequencing reveals pervasive positive selection throughout preleukemic evolution
Single-cell DNA sequencing reveals pervasive positive selection throughout preleukemic evolution Open
View article: Double mutant <i>DNMT3A</i> AML: a unique subtype experiencing increased DNA damage and poor prognosis
Double mutant <i>DNMT3A</i> AML: a unique subtype experiencing increased DNA damage and poor prognosis Open
Mutation of DNMT3A, encoding a de novo methyltransferase essential for cytosine methylation, is a common early event in clonal hematopoiesis (CH) and adult acute myeloid leukemia (AML). Spontaneous deamination of methylated cytosines damag…
View article: Interferon gamma‐mediated prevention of tumor progression in a mouse model of multiple myeloma
Interferon gamma‐mediated prevention of tumor progression in a mouse model of multiple myeloma Open
Malignant plasma cells in multiple myeloma patients reside in the bone marrow and continuously interact with local immune cells. Progression and therapy response are influenced by this immune environment, highlighting the need for a detail…
View article: Combined plasma protein and memory T cell profiling discern IBD-patient-immunotypes related to intestinal disease and treatment outcomes
Combined plasma protein and memory T cell profiling discern IBD-patient-immunotypes related to intestinal disease and treatment outcomes Open
View article: Table S7 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Table S7 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML Open
Table S7 Gene list reflecting the inflammatory remodeling of stromal niches in AML
View article: Table S1 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Table S1 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML Open
Table S1 patient characteristics
View article: Table S4 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Table S4 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML Open
Table S4 Differentially expressed genes and transcriptional programs (GSEA Hallmark) in BMSCs from AML vs. BMSCs from NBM (scRNAseq)
View article: Table S2 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Table S2 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML Open
Table S2 Differentially expressed genes in the HSC (low-output) cluster 0 vs. (high-output) HSC/MPP clusters 1-4
View article: Table S6 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Table S6 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML Open
Supplementary Table 6. Differentially expressed genes in BMSCs from AML vs. BMSCs from NBM (purified BMSC RNAseq)
View article: Table S1 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Table S1 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML Open
Table S1 patient characteristics
View article: Supplementary Figure 1-9 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Supplementary Figure 1-9 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML Open
Fig S1-S9
View article: Supplementary Figure 1-9 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Supplementary Figure 1-9 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML Open
Fig S1-S9
View article: Table S2 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Table S2 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML Open
Table S2 Differentially expressed genes in the HSC (low-output) cluster 0 vs. (high-output) HSC/MPP clusters 1-4
View article: Table S5 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Table S5 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML Open
Table S5 Differentially expressed genes in residual normal/pre-leukemic HSCs in AML vs. HSCs from NBM (scRNAseq)
View article: Table S5 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Table S5 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML Open
Table S5 Differentially expressed genes in residual normal/pre-leukemic HSCs in AML vs. HSCs from NBM (scRNAseq)
View article: Table S3 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Table S3 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML Open
Supplementary Table 3. Differentially expressed genes in the NBM BMSC cluster 0 vs. other BMSC clusters
View article: Table S7 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Table S7 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML Open
Table S7 Gene list reflecting the inflammatory remodeling of stromal niches in AML
View article: Table S6 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Table S6 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML Open
Supplementary Table 6. Differentially expressed genes in BMSCs from AML vs. BMSCs from NBM (purified BMSC RNAseq)
View article: Table S4 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Table S4 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML Open
Table S4 Differentially expressed genes and transcriptional programs (GSEA Hallmark) in BMSCs from AML vs. BMSCs from NBM (scRNAseq)
View article: Table S3 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Table S3 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML Open
Supplementary Table 3. Differentially expressed genes in the NBM BMSC cluster 0 vs. other BMSC clusters
View article: The genomic basis of childhood T-lineage acute lymphoblastic leukaemia
The genomic basis of childhood T-lineage acute lymphoblastic leukaemia Open
View article: G-quadruplexes are a source of vulnerability in<i>BRCA2</i>deficient granule cell progenitors and medulloblastoma
G-quadruplexes are a source of vulnerability in<i>BRCA2</i>deficient granule cell progenitors and medulloblastoma Open
Biallelic pathogenic variants in the essential DNA repair gene BRCA2 causes Fanconi anemia, complementation group FA-D1. Patients in this group are highly prone to develop embryonal tumors, most commonly medulloblastoma arising from the ce…