Mathilde C. C. Guillaumin
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View article: Deficient synaptic neurotransmission results in a persistent sleep-like cortical activity across vigilance states in mice
Deficient synaptic neurotransmission results in a persistent sleep-like cortical activity across vigilance states in mice Open
Growing evidence suggests that brain activity during sleep, as well as sleep regulation, are tightly linked with synaptic function and network excitability at the local and global levels. We previously reported that a mutation in synaptobr…
View article: Somnotate: A probabilistic sleep stage classifier for studying vigilance state transitions
Somnotate: A probabilistic sleep stage classifier for studying vigilance state transitions Open
Electrophysiological recordings from freely behaving animals are a widespread and powerful mode of investigation in sleep research. These recordings generate large amounts of data that require sleep stage annotation (polysomnography), in w…
View article: Disentangling the role of NAc D1 and D2 cells in hedonic eating
Disentangling the role of NAc D1 and D2 cells in hedonic eating Open
Overeating is driven by both the hedonic component (‘liking’) of food, and the motivation (‘wanting’) to eat it. The nucleus accumbens (NAc) is a key brain center implicated in these processes, but how distinct NAc cell populations encode …
View article: Deficient synaptic neurotransmission results in a persistent sleep-like cortical activity across vigilance states in mice
Deficient synaptic neurotransmission results in a persistent sleep-like cortical activity across vigilance states in mice Open
Growing evidence suggests that brain activity during sleep, as well as sleep regulation, are tightly linked with synaptic function and network excitability at the local and global levels. We previously reported that a mutation in synaptobr…
View article: Something to Snack on: Can Dietary Modulators Boost Mind and Body?
Something to Snack on: Can Dietary Modulators Boost Mind and Body? Open
The last decades have shown that maintaining a healthy and balanced diet can support brain integrity and functionality, while an inadequate diet can compromise it. However, still little is known about the effects and utility of so-called h…
View article: Maternal Over- and Malnutrition and Increased Risk for Addictive and Eating Disorders in the Offspring
Maternal Over- and Malnutrition and Increased Risk for Addictive and Eating Disorders in the Offspring Open
Evidence from human and animal studies has shown that maternal overnutrition and/or obesity are linked with neurobehavioral changes in the offspring. This fetal programming is characterized by adaptive responses to changes in the nutrition…
View article: Detection of neuronal OFF periods as low amplitude neural activity segments
Detection of neuronal OFF periods as low amplitude neural activity segments Open
Background During non-rapid eye movement sleep (NREM), alternating periods of synchronised high (ON period) and low (OFF period) neuronal activity are associated with high amplitude delta band (0.5–4 Hz) oscillations in neocortical electro…
View article: Disentangling the role of NAc D1 and D2 cells in hedonic eating
Disentangling the role of NAc D1 and D2 cells in hedonic eating Open
Overeating is driven by both the hedonic component (‘liking’) of food, and the motivation (‘wanting’) to eat it. The nucleus accumbens (NAc) is a key brain center implicated in these processes, but how distinct NAc cell populations encode …
View article: Detection of neuronal OFF periods as low amplitude neural activity segments
Detection of neuronal OFF periods as low amplitude neural activity segments Open
During non-rapid eye movement sleep (NREM), synchronised neuronal activity is reflected in a specific neural oscillation observed in neocortical electrophysiological signals: a low frequency component characterised by depth-positive/surfac…
View article: Neuronal‐spiking‐based closed‐loop stimulation during cortical <scp>ON</scp> ‐ and <scp>OFF</scp> ‐states in freely moving mice
Neuronal‐spiking‐based closed‐loop stimulation during cortical <span>ON</span> ‐ and <span>OFF</span> ‐states in freely moving mice Open
Summary The slow oscillation is a central neuronal dynamic during sleep, and is generated by alternating periods of high and low neuronal activity (ON‐ and OFF‐states). Mounting evidence causally links the slow oscillation to sleep's funct…
View article: Neuronal-spiking-based closed-loop stimulation during cortical ON and OFF states in freely moving mice
Neuronal-spiking-based closed-loop stimulation during cortical ON and OFF states in freely moving mice Open
The slow oscillation (SO) is a central neuronal dynamic during sleep and is generated by alternating periods of high and low neuronal activity (ON and OFF states). Mounting evidence causally links the SO to sleep’s functions, and it has re…
View article: The hypothalamic link between arousal and sleep homeostasis in mice
The hypothalamic link between arousal and sleep homeostasis in mice Open
Significance Our current understanding of how sleep is regulated is based upon the model of sleep homeostasis, which defines a variable called Process S as a measure of sleep need, and a so-called “flip-flop” model of state switching, whic…
View article: Somnotate: A probabilistic sleep stage classifier for studying vigilance state transitions
Somnotate: A probabilistic sleep stage classifier for studying vigilance state transitions Open
Electrophysiological recordings from freely behaving animals are a widespread and powerful mode of investigation in sleep research. These recordings generate large amounts of data that require sleep stage annotation (polysomnography), in w…
View article: A role for the cortex in sleep–wake regulation
A role for the cortex in sleep–wake regulation Open
View article: Neuropeptides as Primary Mediators of Brain Circuit Connectivity
Neuropeptides as Primary Mediators of Brain Circuit Connectivity Open
Across sleep and wakefulness, brain function requires inter-neuronal interactions lasting beyond seconds. Yet, most studies of neural circuit connectivity focus on millisecond-scale interactions mediated by the classic fast transmitters, G…
View article: Forward genetics identifies a novel sleep mutant with sleep state inertia and REM sleep deficits
Forward genetics identifies a novel sleep mutant with sleep state inertia and REM sleep deficits Open
A noninvasive sleep screen uncovers a Vamp2 mouse mutation with synaptic deficits underlying substantial sleep disturbances.
View article: Global sleep homeostasis reflects temporally and spatially integrated local cortical neuronal activity
Global sleep homeostasis reflects temporally and spatially integrated local cortical neuronal activity Open
Sleep homeostasis manifests as a relative constancy of its daily amount and intensity. Theoretical descriptions define ‘Process S’, a variable with dynamics dependent on global sleep-wake history, and reflected in electroencephalogram (EEG…
View article: The role of the hypothalamus in cortical arousal and sleep homeostasis
The role of the hypothalamus in cortical arousal and sleep homeostasis Open
Sleep and wakefulness are not simple homogenous all-or-none states, but instead are characterized by rich dynamics of brain activity across many temporal and spatial scales. Rapid global state transitions between waking and sleeping are be…
View article: A role for the cortex in sleep-wake regulation
A role for the cortex in sleep-wake regulation Open
The cortex and subcortical circuitry are thought to play distinct roles in the generation of sleep oscillations and global control of vigilance states. Here we silenced a subset of cortical layer 5 pyramidal and dentate gyrus granule cells…
View article: Author response: Global sleep homeostasis reflects temporally and spatially integrated local cortical neuronal activity
Author response: Global sleep homeostasis reflects temporally and spatially integrated local cortical neuronal activity Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Sleep homeostasis manifests as a relative …
View article: Aberrant synaptic release underlies sleep/wake transition deficits in a mouse<i>Vamp2</i>mutant
Aberrant synaptic release underlies sleep/wake transition deficits in a mouse<i>Vamp2</i>mutant Open
Sleep-wake transitions are modulated through extensive subcortical networks although the precise roles of their individual components remain elusive. Using forward genetics and in vivo electrophysiology, we identified a recessive mouse mut…
View article: Cortical neuronal activity determines the dynamics of local sleep homeostasis
Cortical neuronal activity determines the dynamics of local sleep homeostasis Open
The homeostatic regulation of sleep manifests as a relative constancy of its total daily amount, and the compensation of sleep loss by an increase in its subsequent duration and intensity. Theoretical descriptions of this phenomenon define…
View article: Sleep homeostasis reflects temporally integrated local cortical neuronal activity
Sleep homeostasis reflects temporally integrated local cortical neuronal activity Open
The homeostatic regulation of sleep manifests as a relative constancy of its daily amount and intensity. Theoretical descriptions of this phenomenon define “Process S”, a variable with dynamics dependent only on sleep-wake history, whose l…
View article: Cortical region–specific sleep homeostasis in mice: effects of time of day and waking experience
Cortical region–specific sleep homeostasis in mice: effects of time of day and waking experience Open
Sleep-wake history, wake behaviors, lighting conditions, and circadian time influence sleep, but neither their relative contribution nor the underlying mechanisms are fully understood. The dynamics of electroencephalogram (EEG) slow-wave a…
View article: Investigating the genetic basis of sleep using forward genetics
Investigating the genetic basis of sleep using forward genetics Open
The alternation between waking and sleep is regulated by the internal circadian clock and sleep-wake history, and is also influenced by the external environment. Although our understanding of the circadian aspect of sleep regulation has in…