Mathilde Cheray
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View article: Glioma-induced DNMT3A-dependent reduction of DNA methylation in microglia promotes a transient anti-tumoral phenotype
Glioma-induced DNMT3A-dependent reduction of DNA methylation in microglia promotes a transient anti-tumoral phenotype Open
Glioblastoma, aggressive primary brain tumors with a dismal prognosis, promote the recruitment of microglia, brain resident innate immune cells, and ultimately their activation toward a tumor-supportive phenotype that increases gliomal pro…
View article: ID2-ETS2 axis regulates the transcriptional acquisition of pro-tumoral microglia phenotype in glioma
ID2-ETS2 axis regulates the transcriptional acquisition of pro-tumoral microglia phenotype in glioma Open
Glioblastoma is a highly aggressive brain tumour that creates an immunosuppressive microenvironment. Microglia, the brain’s resident immune cells, play a crucial role in this environment. Glioblastoma cells can reprogramme microglia to cre…
View article: ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain
ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain Open
Molecular diversity of microglia, the resident immune cells in the CNS, is reported. Whether microglial subsets characterized by the expression of specific proteins constitute subtypes with distinct functions has not been fully elucidated.…
View article: ULK3-dependent activation of GLI1 promotes DNMT3A expression upon autophagy induction
ULK3-dependent activation of GLI1 promotes DNMT3A expression upon autophagy induction Open
Macroautophagy/autophagy is a tightly regulated catabolic process, which contributes at baseline level to cellular homeostasis, and upon its stimulation to the adaptive cellular response to intra- and extracellular stress stimuli. Decrease…
View article: <i>Arg1</i> <sup>+</sup> microglia are critical for shaping cognition in female mice
<i>Arg1</i> <sup>+</sup> microglia are critical for shaping cognition in female mice Open
Diversity within microglia, the resident brain immune cells, is reported. Whether microglial subsets constitute different subtypes with intrinsic properties and unique functions has not been fully elucidated. Here, we describe a microglial…
View article: Additional file 2 of Atg7 deficiency in microglia drives an altered transcriptomic profile associated with an impaired neuroinflammatory response
Additional file 2 of Atg7 deficiency in microglia drives an altered transcriptomic profile associated with an impaired neuroinflammatory response Open
Additional file 2. DEG lists and KEGG pathways comparing shCtrl BV2 cells with shAtg7 BV2 cells.
View article: Additional file 3 of Atg7 deficiency in microglia drives an altered transcriptomic profile associated with an impaired neuroinflammatory response
Additional file 3 of Atg7 deficiency in microglia drives an altered transcriptomic profile associated with an impaired neuroinflammatory response Open
Additional file 3. DEG lists and KEGG pathways comparing LPS-treated shAtg7 BV2 with untreated shAtg7 BV2 cellsdat.
View article: Additional file 5 of Atg7 deficiency in microglia drives an altered transcriptomic profile associated with an impaired neuroinflammatory response
Additional file 5 of Atg7 deficiency in microglia drives an altered transcriptomic profile associated with an impaired neuroinflammatory response Open
Additional file 5. Metascape GO term clusters for overlap with C7: immunologic signature genes.
View article: Inhibition of microglial EZH2 leads to anti-tumoral effects in pediatric diffuse midline gliomas
Inhibition of microglial EZH2 leads to anti-tumoral effects in pediatric diffuse midline gliomas Open
Background Diffuse intrinsic pontine gliomas (DIPG), within diffuse midline gliomas are aggressive pediatric brain tumors characterized by histone H3-K27M mutation. Small-molecule inhibitors for the EZH2-H3K27 histone methyltransferase hav…
View article: Additional file 4 of Atg7 deficiency in microglia drives an altered transcriptomic profile associated with an impaired neuroinflammatory response
Additional file 4 of Atg7 deficiency in microglia drives an altered transcriptomic profile associated with an impaired neuroinflammatory response Open
Additional file 4. Venn diagram gene lists and Metascape GO term clusters.
View article: The DNA methyltransferase DNMT3A contributes to autophagy long-term memory
The DNA methyltransferase DNMT3A contributes to autophagy long-term memory Open
Macroautophagy/autophagy is a conserved catabolic pathway that targets cytoplasmic components for their degradation and recycling in an autophagosome-dependent lysosomal manner. Under physiological conditions, this process maintains cellul…
View article: Additional file 4 of Cytosine methylation of mature microRNAs inhibits their functions and is associated with poor prognosis in glioblastoma multiforme
Additional file 4 of Cytosine methylation of mature microRNAs inhibits their functions and is associated with poor prognosis in glioblastoma multiforme Open
Additional file 4. Results of BS experiments.
View article: Additional file 3 of Cytosine methylation of mature microRNAs inhibits their functions and is associated with poor prognosis in glioblastoma multiforme
Additional file 3 of Cytosine methylation of mature microRNAs inhibits their functions and is associated with poor prognosis in glioblastoma multiforme Open
Additional file 3. Statistical analysis of BS experiments.
View article: Additional file 5 of Cytosine methylation of mature microRNAs inhibits their functions and is associated with poor prognosis in glioblastoma multiforme
Additional file 5 of Cytosine methylation of mature microRNAs inhibits their functions and is associated with poor prognosis in glioblastoma multiforme Open
Additional file 5. Sequence of selected miRNA-BS.
View article: Additional file 6 of Cytosine methylation of mature microRNAs inhibits their functions and is associated with poor prognosis in glioblastoma multiforme
Additional file 6 of Cytosine methylation of mature microRNAs inhibits their functions and is associated with poor prognosis in glioblastoma multiforme Open
Additional file 6. Results of selected miRNA-BS.
View article: Additional file 7 of Cytosine methylation of mature microRNAs inhibits their functions and is associated with poor prognosis in glioblastoma multiforme
Additional file 7 of Cytosine methylation of mature microRNAs inhibits their functions and is associated with poor prognosis in glioblastoma multiforme Open
Additional file 7. Results of 5mC-RIP-Array analyses.
View article: The DNA methyltransferase DNMT3A contributes to autophagy long-term memory
The DNA methyltransferase DNMT3A contributes to autophagy long-term memory Open
Macroautophagy/autophagy is a conserved catabolic pathway that targets cytoplasmic components for their degradation and recycling in an autophagosome-dependent lysosomal manner. Under physiological conditions, this process maintains cellul…
View article: The Rules of Engagement: Do Microglia Seal the Fate in the Inverse Relation of Glioma and Alzheimer’s Disease?
The Rules of Engagement: Do Microglia Seal the Fate in the Inverse Relation of Glioma and Alzheimer’s Disease? Open
Microglia, the immune cells of the brain, play a major role in the maintenance of brain homeostasis and constantly screen the brain environment to detect any infection or damage. Once activated by a stimulus, microglial cells initiate an i…
View article: TET2 Regulates the Neuroinflammatory Response in Microglia
TET2 Regulates the Neuroinflammatory Response in Microglia Open
Epigenomic mechanisms regulate distinct aspects of the inflammatory response in immune cells. Despite the central role for microglia in neuroinflammation and neurodegeneration, little is known about their epigenomic regulation of the infla…
View article: TET2 regulates the neuroinflammatory response in microglia
TET2 regulates the neuroinflammatory response in microglia Open
Summary Epigenetic mechanisms regulate distinct aspects of the inflammatory response in various immune cell types. Despite the central role for microglia, the resident macrophages of the brain, in neuroinflammation and neurodegeneration li…
View article: Epigenetics Control Microglia Plasticity
Epigenetics Control Microglia Plasticity Open
Microglia, resident immune cells of the central nervous system, fulfill multiple functions in the brain throughout life. These microglial functions range from participation in innate and adaptive immune responses, involvement in the develo…
View article: Glioma-induced SIRT1-dependent activation of hMOF histone H4 lysine 16 acetyltransferase in microglia promotes a tumor supporting phenotype
Glioma-induced SIRT1-dependent activation of hMOF histone H4 lysine 16 acetyltransferase in microglia promotes a tumor supporting phenotype Open
High-grade gliomas are malignant aggressive primary brain tumors with limited therapeutic options, and dismal prognosis for patients. Microglia, the resident immune cells of the brain, are recruited and reprogrammed into tumor-supporting c…
View article: <i><scp>KLRC</scp>3</i>, a Natural Killer receptor gene, is a key factor involved in glioblastoma tumourigenesis and aggressiveness
<i><span>KLRC</span>3</i>, a Natural Killer receptor gene, is a key factor involved in glioblastoma tumourigenesis and aggressiveness Open
Glioblastoma is the most lethal brain tumour with a poor prognosis. Cancer stem cells ( CSC ) were proposed to be the most aggressive cells allowing brain tumour recurrence and aggressiveness. Current challenge is to determine CSC signatur…
View article: Specific Inhibition of DNMT3A/ISGF3γ Interaction Increases the Temozolomide Efficiency to Reduce Tumor Growth
Specific Inhibition of DNMT3A/ISGF3γ Interaction Increases the Temozolomide Efficiency to Reduce Tumor Growth Open
DNA methylation is a fundamental feature of genomes and is a candidate for pharmacological manipulation that might have important therapeutic advantage. Thus, DNA methyltransferases (DNMTs) appear to be ideal targets for drug intervention.…