Mathilde Keck
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View article: Nanobody therapy rescues behavioural deficits of NMDA receptor hypofunction
Nanobody therapy rescues behavioural deficits of NMDA receptor hypofunction Open
There is an urgent need for efficient and innovative therapies to treat brain disorders such as psychiatric and neurodegenerative diseases. Immunotherapies have proved to be efficient in many medical areas, but have not been considered to …
View article: Antagonisation of Prokineticin Receptor‐2 Attenuates Preeclampsia Symptoms
Antagonisation of Prokineticin Receptor‐2 Attenuates Preeclampsia Symptoms Open
Preeclampsia (PE) is the most threatening pathology of human pregnancy. Placenta from PE patients releases harmful factors that contribute to the exacerbation of the disease. Among these factors is the prokineticin1 (PROK1) and its recepto…
View article: A Snake Toxin Derivative for Treatment of Hyponatremia and Polycystic Kidney Diseases
A Snake Toxin Derivative for Treatment of Hyponatremia and Polycystic Kidney Diseases Open
Key Points MQ232, a disulfide-bond reticulated peptide derived from a natural snake toxin, was optimized as a new aquaretic drug candidate. MQ232 showed very low acute and chronic toxicity in rat and a biodistribution in mice strongly in f…
View article: Environmental and Health Impacts of Graphene and Other Two-Dimensional Materials: A Graphene Flagship Perspective
Environmental and Health Impacts of Graphene and Other Two-Dimensional Materials: A Graphene Flagship Perspective Open
Two-dimensional (2D) materials have attracted tremendous interest ever since the isolation of atomically thin sheets of graphene in 2004 due to the specific and versatile properties of these materials. However, the increasing production an…
View article: A cancer immunoprofiling strategy using mass spectrometry coupled with bioorthogonal cleavage
A cancer immunoprofiling strategy using mass spectrometry coupled with bioorthogonal cleavage Open
Cancer immuno-profiling: The combination of bioorthogonal chemistry and LC-MS/MS-analysis was successfully used for imaging and quantifying overexpressed cancer receptors in cells, tissues and in vivo .
View article: A New Derivative of Retro-2 Displays Antiviral Activity against Respiratory Syncytial Virus
A New Derivative of Retro-2 Displays Antiviral Activity against Respiratory Syncytial Virus Open
Human respiratory syncytial virus (hRSV) is the most common cause of bronchiolitis and pneumonia in newborns, with all children being infected before the age of two. Reinfections are very common throughout life and can cause severe respira…
View article: Acute Effects of Brevetoxin-3 Administered via Oral Gavage to Mice
Acute Effects of Brevetoxin-3 Administered via Oral Gavage to Mice Open
Brevetoxins (BTXs) constitute a family of lipid-soluble toxic cyclic polyethers mainly produced by Karenia brevis, which is the main vector for a foodborne syndrome known as neurotoxic shellfish poisoning (NSP) in humans. To prevent health…
View article: A New Derivative of Retro-2 Displays Antiviral Activity against Respiratory Syncytial Virus
A New Derivative of Retro-2 Displays Antiviral Activity against Respiratory Syncytial Virus Open
Human respiratory syncytial virus (hRSV) is the most common cause of bronchiolitis and pneumonia in new-borns, with all children being infected before the age of two. Reinfections are very common throughout life, and can cause severe respi…
View article: One-year post-exposure assessment of <sup>14</sup>C-few-layer graphene biodistribution in mice: single <i>versus</i> repeated intratracheal administration
One-year post-exposure assessment of <sup>14</sup>C-few-layer graphene biodistribution in mice: single <i>versus</i> repeated intratracheal administration Open
Long-term investigation of the biodistribution of 14 C-few-layer graphene after tracheal administration: repeated vs. single exposure.
View article: From a Cone Snail Toxin to a Competitive MC4R Antagonist
From a Cone Snail Toxin to a Competitive MC4R Antagonist Open
The melanocortin 4 receptor (MC4R) plays a role in energy homeostasis and represents a target for treating energy balance disorders. For decades, synthetic ligands have been derived from MC4R endogenous agonists and antagonists, such as se…
View article: C910 chemical compound inhibits the traffiking of several bacterial AB toxins with cross-protection against influenza virus
C910 chemical compound inhibits the traffiking of several bacterial AB toxins with cross-protection against influenza virus Open
The development of anti-infectives against a large range of AB-like toxin-producing bacteria includes the identification of compounds disrupting toxin transport through both the endolysosomal and retrograde pathways. Here, we performed a h…
View article: Monitoring In Vivo Performances of Protein–Drug Conjugates Using Site-Selective Dual Radiolabeling and Ex Vivo Digital Imaging
Monitoring In Vivo Performances of Protein–Drug Conjugates Using Site-Selective Dual Radiolabeling and Ex Vivo Digital Imaging Open
In preclinical models, the development and optimization of protein-drug conjugates require accurate determination of the plasma and tissue profiles of both the protein and its conjugated drug. To this aim, we developed a bioanalytical stra…
View article: A new Kunitz‐type snake toxin family associated with an original mode of interaction with the vasopressin 2 receptor
A new Kunitz‐type snake toxin family associated with an original mode of interaction with the vasopressin 2 receptor Open
Background and Purpose Venomous animals express numerous Kunitz‐type peptides. The mambaquaretin‐1 (MQ1) peptide identified from the Dendroaspis angusticeps venom is the most selective antagonist of the arginine‐vasopressin V2 receptor (V2…
View article: QGC606: A Best-in-Class Orally Active Centrally Acting Aminopeptidase A Inhibitor Prodrug for Treating Heart Failure Following Myocardial Infarction
QGC606: A Best-in-Class Orally Active Centrally Acting Aminopeptidase A Inhibitor Prodrug for Treating Heart Failure Following Myocardial Infarction Open
Chronic oral QGC606 administration in post-MI mice showed beneficial effects in improving cardiac function and reducing cardiac remodeling and fibrosis but, unlike ramipril, without lowering BP.
View article: A screening pipeline identifies a broad-spectrum inhibitor of bacterial AB toxins with cross protection against influenza A virus H1N1 and SARS-CoV-2
A screening pipeline identifies a broad-spectrum inhibitor of bacterial AB toxins with cross protection against influenza A virus H1N1 and SARS-CoV-2 Open
A challenge for the development of host-targeted anti-infectives against a large spectrum of AB-like toxin-producing bacteria encompasses the identification of chemical compounds corrupting toxin transport through both endolysosomal and re…
View article: LIT01-196, a Metabolically Stable Apelin-17 Analog, Normalizes Blood Pressure in Hypertensive DOCA-Salt Rats via a NO Synthase-dependent Mechanism
LIT01-196, a Metabolically Stable Apelin-17 Analog, Normalizes Blood Pressure in Hypertensive DOCA-Salt Rats via a NO Synthase-dependent Mechanism Open
Apelin is a neuro-vasoactive peptide that plays a major role in the control of cardiovascular functions and water balance, but has an in-vivo half-life in the minute range, limiting its therapeutic use. We previously developed LIT01-196, a…
View article: A new Kunitz-type snake toxin family associated with an original mode of interaction with the vasopressin 2 receptor.
A new Kunitz-type snake toxin family associated with an original mode of interaction with the vasopressin 2 receptor. Open
Background and purpose. Venomous animals express numerous Kunitz-type peptides. The mambaquaretin-1 (MQ1) recently identified from the Dendroaspis angusticeps venom is the most selective antagonist of the arginine-vasopressin V2 receptor (…
View article: A variant of ASIC2 mediates sodium retention in nephrotic syndrome
A variant of ASIC2 mediates sodium retention in nephrotic syndrome Open
Idiopathic nephrotic syndrome (INS) is characterized by proteinuria and renal sodium retention leading to edema. This sodium retention is usually attributed to epithelial sodium channel (ENaC) activation after plasma aldosterone increase. …
View article: First evidence that emerging pinnatoxin-G, a contaminant of shellfish, reaches the brain and crosses the placental barrier
First evidence that emerging pinnatoxin-G, a contaminant of shellfish, reaches the brain and crosses the placental barrier Open
Massive proliferation of some toxic marine dinoflagellates is responsible for the occurrence of harmful algal blooms and the contamination of fish and shellfish worldwide. Pinnatoxins (PnTx) (A-H) comprise an emerging phycotoxin family bel…
View article: A new variant of ASIC2 mediates sodium retention in nephrotic syndrome
A new variant of ASIC2 mediates sodium retention in nephrotic syndrome Open
Idiopathic nephrotic syndrome (INS) is characterized by proteinuria and renal Na retention leading to oedema. This Na retention is usually attributed to epithelial sodium channel (ENaC) activation following plasma aldosterone increase. How…
View article: NI956/QGC006, a Potent Orally Active, Brain-Penetrating Aminopeptidase A Inhibitor for Treating Hypertension
NI956/QGC006, a Potent Orally Active, Brain-Penetrating Aminopeptidase A Inhibitor for Treating Hypertension Open
Brain renin-angiotensin system hyperactivity has been implicated in the development and maintenance of hypertension. We have shown that aminopeptidase A is involved in the formation of brain angiotensin III, which exerts tonic stimulatory …
View article: Clinical and Genetic Spectrum of Bartter Syndrome Type 3
Clinical and Genetic Spectrum of Bartter Syndrome Type 3 Open
Bartter syndrome type 3 is a clinically heterogeneous hereditary salt-losing tubulopathy caused by mutations of the chloride voltage-gated channel Kb gene ( CLCNKB ), which encodes the ClC-Kb chloride channel involved in NaCl reabsorption …
View article: The ClC-K2 Chloride Channel Is Critical for Salt Handling in the Distal Nephron
The ClC-K2 Chloride Channel Is Critical for Salt Handling in the Distal Nephron Open
Chloride transport by the renal tubule is critical for blood pressure (BP), acid-base, and potassium homeostasis. Chloride uptake from the urinary fluid is mediated by various apical transporters, whereas basolateral chloride exit is thoug…
View article: ClC-K chloride channels: emerging pathophysiology of Bartter syndrome type 3
ClC-K chloride channels: emerging pathophysiology of Bartter syndrome type 3 Open
The mutations in the CLCNKB gene encoding the ClC-Kb chloride channel are responsible for Bartter syndrome type 3, one of the four variants of Bartter syndrome in the genetically based nomenclature. All forms of Bartter syndrome are charac…