Mathilde Lethier
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View article: The molecular dissection of TRIM25’s RNA-binding mechanism provides key insights into its antiviral activity
The molecular dissection of TRIM25’s RNA-binding mechanism provides key insights into its antiviral activity Open
TRIM25 is an RNA-binding ubiquitin E3 ligase with central but poorly understood roles in the innate immune response to RNA viruses. The link between TRIM25’s RNA binding and its role in innate immunity has not been established. Thus, we ut…
View article: The RNA receptor RIG-I binding synthetic oligodeoxynucleotide promotes pneumonia survival
The RNA receptor RIG-I binding synthetic oligodeoxynucleotide promotes pneumonia survival Open
Pneumonia is a worldwide threat to public health, demanding novel preventative and therapeutic strategies. The lung epithelium is a critical environmental interface that functions as a physical barrier to pathogen invasion while also activ…
View article: The molecular dissection of TRIM25‘s RNA-binding mechanism provides key insights into its antiviral activity
The molecular dissection of TRIM25‘s RNA-binding mechanism provides key insights into its antiviral activity Open
TRIM25 is an RNA-binding ubiquitin E3 ligase with central but poorly understood roles in the innate immune response to RNA viruses. The link between TRIM25’s RNA binding and its role in innate immunity has not been established. Thus, we ut…
View article: Structure shows that the BIR2 domain of E3 ligase XIAP binds across the RIPK2 kinase dimer interface
Structure shows that the BIR2 domain of E3 ligase XIAP binds across the RIPK2 kinase dimer interface Open
RIPK2 is an essential adaptor for NOD signalling and its kinase domain is a drug target for NOD-related diseases, such as inflammatory bowel disease. However, recent work indicates that the phosphorylation activity of RIPK2 is dispensable …
View article: Structural analysis shows that the BIR2 domain of E3 ligase XIAP binds across the RIP2 kinase dimer interface
Structural analysis shows that the BIR2 domain of E3 ligase XIAP binds across the RIP2 kinase dimer interface Open
NOD1 and NOD2 are innate immune system pattern recognition receptors that play a key role in the protection from bacterial infections and in the maintenance of gastro-intestinal homeostasis. Dysregulation of NOD signalling pathways promote…
View article: Mechanistic insights into RNA binding and RNA-regulated RIG-I ubiquitination by TRIM25
Mechanistic insights into RNA binding and RNA-regulated RIG-I ubiquitination by TRIM25 Open
TRIM25 is a ubiquitin E3 ligase active in innate immunity and cell fate decisions. Mounting evidence suggests that TRIM25′s E3 ligase activity is regulated by RNAs. However, while mutations affecting RNA binding have been described, neithe…
View article: Porin self-association enables cell-to-cell contact in <i>Providencia stuartii</i> floating communities
Porin self-association enables cell-to-cell contact in <i>Providencia stuartii</i> floating communities Open
Significance We report that porins, the main gateway for hydrophilic nutrients and ions into bacterial cells, assemble face-to-face in crystals, yielding dimers of trimers (DOTs). Further investigation suggests that DOTs could support cell…
View article: Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors
Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors Open
Influenza polymerase uses short capped primers snatched from nascent Pol II transcripts to initiate transcription of viral mRNAs. Here we describe crystal structures of influenza A and B polymerase bound to a capped primer in a configurati…