Mathilde Stéphanie Willemin

Conditional essentiality of the 11-subunit complex I-like enzyme in strict anaerobes: the case of Desulfitobacterium hafniense strain DCB-2 Open

Mathilde Stéphanie Willemin, Florence Armand, Romain Hamelin, Julien Maillard, Christof Holliger · 2024

In oxidative phosphorylation, respiratory complex I serves as an entry point in the electron transport chain for electrons generated in catabolic processes in the form of NADH. An ancestral version of the complex, lacking the NADH-oxidisin…

Proteome adaptations of the organohalide-respiring Desulfitobacterium hafniense strain DCB-2 to various energy metabolisms Open

Mathilde Stéphanie Willemin, Romain Hamelin, Florence Armand, Christof Holliger, Julien Maillard · 2023

Introduction Desulfitobacterium hafniense was isolated for its ability to use organohalogens as terminal electron acceptors via organohalide respiration (OHR). In contrast to obligate OHR bacteria, Desulfitobacterium spp. show a highly ver…

Hybrid Transcriptional Regulators for the Screening of Target DNA Motifs in Organohalide-Respiring Bacteria Open

Mathilde Stéphanie Willemin, Marie Vingerhoets, Christof Holliger, Julien Maillard · 2020

The bioremediation of persistent organohalide molecules under anoxic conditions mostly relies on the bacterial process called organohalide respiration (OHR). Organohalide-respiring bacteria (OHRB) are phylogenetically diverse anaerobic bac…

Involvement of respiratory complex I in organohalide respiration Open

Mathilde Stéphanie Willemin, Julien Maillard, Christof Holliger · 2019

Background The NADH:ubiquinone oxidoreductase (Nuo) is an assembly of proteins also known as complex I. It is the entry point for highly energetic electrons in the classical aerobic respiration process as it couples the transfer of two ele…

RDHK Family, Regulators dedicated to Organohalide Respiration - Sequence Diversity and Functional Prediction Open

Mathilde Stéphanie Willemin, Christof Holliger, Julien Maillard · 2019

Organohalide respiration (OHR) is an anaerobic metabolism by which bacteria conserve energy from the use of organohalide molecules as terminal electron acceptors. Because most organohalides of anthropogenic origin are persistent pollutants…

Regulation of organohalide respiration Open

Julien Maillard, Mathilde Stéphanie Willemin · 2019

RdhC, a family of membrane-bound flavoproteins involved in electron transfer in organohalide respiration ? Open

Julien Maillard, Géraldine Florence Buttet, Mathilde Stéphanie Willemin, Romain Hamelin · 2018

Organohalide respiration (OHR) is a bacterial energy metabolism making use of halogenated compounds – like tetrachloroethene (PCE), a major pollutant – as terminal electron acceptors. Three models of electron transport chain exist for OHR …

Identifying the role of complex I in organohalide respiration of Firmicutes Open

Mathilde Stéphanie Willemin, Romain Hamelin, Christof Holliger, Julien Maillard · 2018

Organohalide-respiring bacteria (OHRB) are capable to link energy conservation with the use of organohalide compounds as terminal electron acceptors. While obligate OHRB relies only on this process for growing, facultative OHRB are able to…

In vivo regulation of organohalide respiration in Desulfitobacterium hafniense DCB-2 Open

Céline Berruex, Marie Vingerhoets, Mathilde Stéphanie Willemin, Julien Maillard · 2018

Background Organohalide respiration (OHR) is a bacterial anaerobic respiratory metabolism which takes advantage of halogenated compounds (= organohalides) as terminal electron acceptors. While its environmental interest does not have to be…

Explore RdhK based regulatory network of organohalide respiration using a hybrid proteins strategy Open

Mathilde Stéphanie Willemin, Christof Holliger, Julien Maillard · 2018

Reductive dehalogenase (rdh) gene clusters encode for proteins involved in organohalide respiration (OHR), a bacterial process where organohalide compounds are used as terminal electron acceptors. RdhK proteins, members of the CRP/FNR fami…

The Membrane-Bound C Subunit of Reductive Dehalogenases: Topology Analysis and Reconstitution of the FMN-Binding Domain of PceC Open

Géraldine Florence Buttet, Mathilde Stéphanie Willemin, Romain Hamelin, Aamani Rupakula, Julien Maillard · 2018

Organohalide respiration (OHR) is the energy metabolism of anaerobic bacteria able to use halogenated organic compounds as terminal electron acceptors. While the terminal enzymes in OHR, so-called reductive dehalogenases, are well-characte…

Biogenesis of the mitochondrial DNA inheritance machinery in the mitochondrial outer membrane of Trypanosoma brucei Open

Sandro Käser, Mathilde Stéphanie Willemin, Felix Schnarwiler, Bernd Schimanski, Daniel Poveda-Huertes , et al. · 2017

Mitochondria cannot form de novo but require mechanisms that mediate their inheritance to daughter cells. The parasitic protozoan Trypanosoma brucei has a single mitochondrion with a single-unit genome that is physically connected across t…

Biogenesis of a mitochondrial DNA inheritance machinery in the mitochondrial outer membrane Open

Sandro Käser, Mathilde Stéphanie Willemin, Felix Schnarwiler, Bernd Schimanski, Daniel Poveda-Huertes , et al. · 2017

Mitochondria cannot form de novo but require mechanisms that mediate their inheritance to daughter cells. The parasitic protozoan Trypanosoma brucei has a single mitochondrion with a single-unit genome that is physically connected across t…

Hybrid proteins for the screening of transcription regulators of reductive dehalogenase gene clusters Open

Mathilde Stéphanie Willemin, Christof Holliger, Julien Maillard · 2017

In the past decade, research on the transcription regulation of reductive dehalogenase (rdh) gene clusters (for a recent review, see [1]) revealed a new set of CRP/FNR-type transcription regulators, called RdhK [2,3]. Several members of th…

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