Mathilde Tomaszczyk
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View article: Targeting bacterial kinases as a strategy to counteract antibiotic resistance
Targeting bacterial kinases as a strategy to counteract antibiotic resistance Open
Antibiotic resistance is rapidly emerging as one of the most critical health threats, with resistant microorganisms progressively diminishing the effectiveness of established antibiotics. As a result, the development of therapeutic approac…
View article: Fragment-based drug design of a bacterial kinase inhibitor capable of increasing the antibiotic sensitivity of clinical isolates
Fragment-based drug design of a bacterial kinase inhibitor capable of increasing the antibiotic sensitivity of clinical isolates Open
According to the World Health Organization (WHO), antimicrobial resistance is a serious global health issue. Overcoming antibiotic resistance involves several strategies, including the inhibition of resistance mechanisms. Among the various…
View article: <scp>HadBD</scp> dehydratase from <scp><i>Mycobacterium tuberculosis</i></scp> fatty acid synthase type <scp>II</scp>: A singular structure for a unique function
<span>HadBD</span> dehydratase from <span><i>Mycobacterium tuberculosis</i></span> fatty acid synthase type <span>II</span>: A singular structure for a unique function Open
Worldwide, tuberculosis is the second leading infectious killer and multidrug resistance severely hampers disease control. Mycolic acids are a unique category of lipids that are essential for viability, virulence, and persistence of the ca…