Matías L. Pidre
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View article: Baculovirus-Mediated Gene Therapy: Targeting BIRC6 for Lung and Breast Cancer
Baculovirus-Mediated Gene Therapy: Targeting BIRC6 for Lung and Breast Cancer Open
BIRC6, a member of the inhibitor of apoptosis protein family (IAP), regulates apoptosis, autophagy and cytokinesis. IAPs are often overexpressed in tumors, contributing to oncogenesis, therapy resistance and worse prognosis. In particular,…
View article: Proteomic Characterization of Spodoptera frugiperda Granulovirus Occlusion Bodies
Proteomic Characterization of Spodoptera frugiperda Granulovirus Occlusion Bodies Open
Lepidopteran-infecting baculoviruses represent one of the most promising alternatives for pest biocontrol. In particular, Spodoptera frugiperda granulovirus (SfGV) infects the fall armyworm Spodoptera frugiperda , an increasingly important…
View article: RIPK1 in Diffuse Glioma Pathology: From Prognosis Marker to Potential Therapeutic Target
RIPK1 in Diffuse Glioma Pathology: From Prognosis Marker to Potential Therapeutic Target Open
Diffuse gliomas (DGs) are malignant primary brain tumors originating from glial cells. This study aimed to investigate the role of Receptor-interacting protein kinase 1 (RIPK1) in DG pathology. The RIPK1 mRNA expression was analyzed in DG …
View article: Silica-coated magnetic particles for efficient RNA extraction for SARS-CoV-2 detection
Silica-coated magnetic particles for efficient RNA extraction for SARS-CoV-2 detection Open
Molecular diagnostic methods to detect and quantify viral RNA in clinical samples rely on the purification of the genetic material prior to reverse transcription polymerase chain reaction (qRT-PCR). Due to the large number of samples proce…
View article: Role of RIPK1 in Diffuse Gliomas pathology
Role of RIPK1 in Diffuse Gliomas pathology Open
Purpose The aim of the present work was to investigate the role of Receptor-interacting protein kinase 1 (RIPK1) both in mutated and wild type isocitrate dehydrogenase (IDH) Diffuse Gliomas (DG). Patients and Methods We analyzed RIPK1 mRNA…
View article: PluriBAC: A Versatile Baculovirus-Based Modular System to Express Heterologous Genes in Different Biotechnological Platforms
PluriBAC: A Versatile Baculovirus-Based Modular System to Express Heterologous Genes in Different Biotechnological Platforms Open
Baculoviruses are insect-specific pathogens widely used in biotechnology. In particular, the Autographa californica nucleopolyhedrovirus (AcMNPV) has been exploited as a platform for bio-inputs production. This is why the improvement of th…
View article: Mitochondrial Peptide Humanin Facilitates Chemoresistance in Glioblastoma Cells
Mitochondrial Peptide Humanin Facilitates Chemoresistance in Glioblastoma Cells Open
Humanin (HN) is a mitochondrial-derived peptide with robust cytoprotective effects in many cell types. Although the administration of HN analogs has been proposed to treat degenerative diseases, its role in the pathogenesis of cancer is po…
View article: Prokaryotic membrane coat - like proteins: An update
Prokaryotic membrane coat - like proteins: An update Open
View article: Evaluation of Baculoviruses as Gene Therapy Vectors for Brain Cancer
Evaluation of Baculoviruses as Gene Therapy Vectors for Brain Cancer Open
We aimed to assess the potential of baculoviral vectors (BV) for brain cancer gene therapy. We compared them with adenoviral vectors (AdV), which are used in neuro-oncology, but for which there is pre-existing immunity. We constructed BVs …
View article: Silica-Coated Magnetic Particles for Efficient RNA Extraction for SARS-CoV-2 Detection
Silica-Coated Magnetic Particles for Efficient RNA Extraction for SARS-CoV-2 Detection Open
View article: The Magic Staff: A Comprehensive Overview of Baculovirus-Based Technologies Applied to Human and Animal Health
The Magic Staff: A Comprehensive Overview of Baculovirus-Based Technologies Applied to Human and Animal Health Open
Baculoviruses are enveloped, insect-specific viruses with large double-stranded DNA genomes. Among all the baculovirus species, Autographa californica multiple nucleopolyhedrovirus (AcMNPV) is the most studied. Due to its characteristics r…
View article: Exploring the metastatic role of the inhibitor of apoptosis BIRC6 in Breast Cancer
Exploring the metastatic role of the inhibitor of apoptosis BIRC6 in Breast Cancer Open
Breast cancer is the most common cancer as well as the first cause of death by cancer in women worldwide. BIRC6 (baculoviral IAP repeat-containing protein 6) is a member of the inhibitors of apoptosis protein family thought to play an impo…
View article: Mitochondrial humanin peptide acts as a cytoprotective factor in granulosa cell survival
Mitochondrial humanin peptide acts as a cytoprotective factor in granulosa cell survival Open
Humanin (HN) is a short peptide involved in many biological processes such as apoptosis, cell survival, inflammatory response, and reaction to stressors like oxidative stress, between others. In the ovary, a correct balance between pro- an…
View article: Genomic Diversity in a Population of Spodoptera frugiperda Nucleopolyhedrovirus
Genomic Diversity in a Population of Spodoptera frugiperda Nucleopolyhedrovirus Open
Spodoptera frugiperda multiple nucleopolyhedrovirus (SfMNPV) represents a strong candidate to develop environmental-friendly pesticides against the fall armyworm ( Spodoptera frugiperda ), a widespread pest that poses a severe threat to di…
View article: Humanin Promotes Tumor Progression in Experimental Triple Negative Breast Cancer
Humanin Promotes Tumor Progression in Experimental Triple Negative Breast Cancer Open
View article: Baculovirus-Derived Vectors for Immunization and Therapeutic Applications
Baculovirus-Derived Vectors for Immunization and Therapeutic Applications Open
View article: Identification of an Argentinean isolate of Spodoptera frugiperda granulovirus
Identification of an Argentinean isolate of Spodoptera frugiperda granulovirus Open
The fall armyworm, Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae), is an important maize pest. Due to the environmental impact and emergence of resistance caused by chemical pesticides and transgenic events, the use of baculov…
View article: Protein composition of the occlusion bodies of Epinotia aporema granulovirus
Protein composition of the occlusion bodies of Epinotia aporema granulovirus Open
Within family Baculoviridae, members of the Betabaculovirus genus are employed as biocontrol agents against lepidopteran pests, either alone or in combination with selected members of the Alphabaculovirus genus. Epinotia aporema granulovir…
View article: Protein composition of the occlusion bodies of <i>Epinotia aporema</i> granulovirus
Protein composition of the occlusion bodies of <i>Epinotia aporema</i> granulovirus Open
Within family Baculoviridae , members of the Betabaculovirus genus are employed as biocontrol agents against lepidopteran pests, either alone or in combination with selected members of the Alphabaculovirus genus. Epinotia aporema granulovi…
View article: Genomic analysis of an Argentinean isolate of Spodoptera frugiperda granulovirus reveals that various baculoviruses code for Lef-7 proteins with three F-box domains
Genomic analysis of an Argentinean isolate of Spodoptera frugiperda granulovirus reveals that various baculoviruses code for Lef-7 proteins with three F-box domains Open
A new isolate of the Spodoptera frugiperda granulovirus, SfGV ARG, was completely sequenced and analyzed. The SfGV ARG genome is 139,812 bp long and encodes 151 putative open reading frames. Of these ORFs, 56 were found in betabaculoviruse…
View article: Baculovirus-based gene silencing of Humanin for the treatment of pituitary tumors
Baculovirus-based gene silencing of Humanin for the treatment of pituitary tumors Open
View article: Vectores baculovirales combinados: exposición superficial de antígenos y transducción de genes
Vectores baculovirales combinados: exposición superficial de antígenos y transducción de genes Open
Los baculovirus son virus envueltos cuyo genoma consiste en una molécula de DNA doble hebra de entre 80 kpb hasta 180kpb. Los baculovirus han sido ampliamente utilizados con fines biotecnológicos. Una de sus aplicaciones más difundidas con…
View article: Development of a Recombination System for the Generation of Occlusion Positive Genetically Modified Anticarsia Gemmatalis Multiple Nucleopolyhedrovirus
Development of a Recombination System for the Generation of Occlusion Positive Genetically Modified Anticarsia Gemmatalis Multiple Nucleopolyhedrovirus Open
Anticarsia gemmatalis is an important pest in legume crops in South America and it has been successfully controlled using Anticarsia gemmatalis Multiple Nucleopolyhedrovirus (AgMNPV) in subtropical climate zones. Nevertheless, in temperate…