Mats I. Nilsson
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View article: A Multi-Ingredient Supplement Improves Body Re-Composition, Ovarian Aging Markers, and Reproductive Success in Young and Middle-Aged Female Mice
A Multi-Ingredient Supplement Improves Body Re-Composition, Ovarian Aging Markers, and Reproductive Success in Young and Middle-Aged Female Mice Open
Ovarian aging is characterized by mitochondrial dysfunction, oxidative stress, and inflammation. The development of adjunctive treatments that mitigate age-related subfertility is warranted. We examined the benefits of nutraceutical supple…
View article: Obesity and Metabolic Disease Impair the Anabolic Response to Protein Supplementation and Resistance Exercise: A Retrospective Analysis of a Randomized Clinical Trial with Implications for Aging, Sarcopenic Obesity, and Weight Management
Obesity and Metabolic Disease Impair the Anabolic Response to Protein Supplementation and Resistance Exercise: A Retrospective Analysis of a Randomized Clinical Trial with Implications for Aging, Sarcopenic Obesity, and Weight Management Open
Background: Anabolic resistance accelerates muscle loss in aging and obesity, thus predisposing to sarcopenic obesity. Methods: In this retrospective analysis of a randomized clinical trial, we examined baseline predictors of the adaptive …
View article: Circulating exosome‐like vesicle and skeletal muscle microRNAs are altered with age and resistance training
Circulating exosome‐like vesicle and skeletal muscle microRNAs are altered with age and resistance training Open
The age‐related loss of skeletal muscle mass and functionality, known as sarcopenia, is a critical risk factor for morbidity and all‐cause mortality. Resistance exercise training (RET) is the primary countermeasure to fight sarcopenia and …
View article: A Multi-Ingredient Supplement Protects against Obesity and Infertility in Western Diet-Fed Mice
A Multi-Ingredient Supplement Protects against Obesity and Infertility in Western Diet-Fed Mice Open
The Western diet (WD) predisposes to bodyweight gain and obesity and is linked to mitochondrial dysfunction, oxidative damage, inflammation, and multisystem disease, even affecting the reproductive organs, fertility, and pregnancy outcomes…
View article: Single nuclei profiling identifies cell specific markers of skeletal muscle aging, frailty, and senescence
Single nuclei profiling identifies cell specific markers of skeletal muscle aging, frailty, and senescence Open
Aging is accompanied by a loss of muscle mass and function, termed sarcopenia, which causes numerous morbidities and economic burdens in human populations. Mechanisms implicated in age-related sarcopenia or frailty include inflammation, mu…
View article: Effects of a 6-wk Sprint Interval Training Protocol at Different Altitudes on Circulating Extracellular Vesicles
Effects of a 6-wk Sprint Interval Training Protocol at Different Altitudes on Circulating Extracellular Vesicles Open
Purpose This study aimed to investigate the modulation of circulating exosome-like extracellular vesicles (ELVs) after 6 wk of sprint interval training (SIT) at sea level and at 2000, 3000, and 4000 m. Methods Thirty trained endurance male…
View article: Life‐long exercise training and inherited aerobic endurance capacity produce converging gut microbiome signatures in rodents
Life‐long exercise training and inherited aerobic endurance capacity produce converging gut microbiome signatures in rodents Open
High aerobic endurance capacity can be acquired by training and/or inherited. Aerobic exercise training (AET) and aging are linked to altered gut microbiome composition, but it is unknown if the environmental stress of exercise and host ge…
View article: Effects of an acute exercise bout in hypoxia on extracellular vesicle release in healthy and prediabetic subjects
Effects of an acute exercise bout in hypoxia on extracellular vesicle release in healthy and prediabetic subjects Open
The purpose of this study is to investigate exosome-like vesicle (ELV) plasma concentrations and markers of multivesicular body (MVB) biogenesis in skeletal muscle in response to acute exercise. Seventeen healthy [body mass index (BMI): 23…
View article: A Novel Multi-Ingredient Supplement Activates a Browning Program in White Adipose Tissue and Mitigates Weight Gain in High-Fat Diet-Fed Mice
A Novel Multi-Ingredient Supplement Activates a Browning Program in White Adipose Tissue and Mitigates Weight Gain in High-Fat Diet-Fed Mice Open
We investigated the effects of a novel multi-ingredient supplement comprised of polyphenol antioxidants and compounds known to facilitate mitochondrial function and metabolic enhancement (ME) in a mouse model of obesity. In this study, 6-w…
View article: Extracellular Vesicles and Exosomes: Insights From Exercise Science
Extracellular Vesicles and Exosomes: Insights From Exercise Science Open
The benefits of exercise on health and longevity are well-established, and evidence suggests that these effects are partially driven by a spectrum of bioactive molecules released into circulation during exercise (e.g., exercise factors or …
View article: Single nuclei profiling identifies cell specific markers of skeletal muscle aging, sarcopenia and senescence
Single nuclei profiling identifies cell specific markers of skeletal muscle aging, sarcopenia and senescence Open
Aging is accompanied by a loss of muscle mass and function, termed sarcopenia, which causes numerous morbidities and economic burdens in human populations. Mechanisms implicated in age-related sarcopenia include inflammation, muscle stem c…
View article: A Five-Ingredient Nutritional Supplement and Home-Based Resistance Exercise Improve Lean Mass and Strength in Free-Living Elderly
A Five-Ingredient Nutritional Supplement and Home-Based Resistance Exercise Improve Lean Mass and Strength in Free-Living Elderly Open
Old age is associated with lower physical activity levels, suboptimal protein intake, and desensitization to anabolic stimuli, predisposing for age-related muscle loss (sarcopenia). Although resistance exercise (RE) and protein supplementa…
View article: Correction: Lifelong aerobic exercise protects against inflammaging and cancer
Correction: Lifelong aerobic exercise protects against inflammaging and cancer Open
[This corrects the article DOI: 10.1371/journal.pone.0210863.].
View article: Expanding the Clinical Spectrum of LONP1-Related Mitochondrial Cytopathy
Expanding the Clinical Spectrum of LONP1-Related Mitochondrial Cytopathy Open
Pathogenic variants in the LONP1 gene have been associated with CODAS syndrome (Cerebral, Ocular, Dental, Auricular, and Skeletal Anomalies Syndrome). A recent report identified the first newborn case with LONP1-related mitochondrial cytop…
View article: Nutrition and exercise in Pompe disease
Nutrition and exercise in Pompe disease Open
The current standard of care for Pompe disease (PD) is the administration of enzyme replacement therapy (ERT). Exercise and nutrition are often considered as complementary strategies rather than "treatments" per se. Nutritional assessment …
View article: Mitochondria and Aging—The Role of Exercise as a Countermeasure
Mitochondria and Aging—The Role of Exercise as a Countermeasure Open
Mitochondria orchestrate the life and death of most eukaryotic cells by virtue of their ability to supply adenosine triphosphate from aerobic respiration for growth, development, and maintenance of the ‘physiologic reserve’. Although their…
View article: Lifelong aerobic exercise protects against inflammaging and cancer
Lifelong aerobic exercise protects against inflammaging and cancer Open
Biological aging is associated with progressive damage accumulation, loss of organ reserves, and systemic inflammation ('inflammaging'), which predispose for a wide spectrum of chronic diseases, including several types of cancer. In contra…