Mats Christian Højbjerg Lassen
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224. Immunosuppression and RSV Prefusion F Protein Vaccine Effectiveness in Older Adults: A Prespecified Subanalysis from the DAN-RSV Trial Open
Background Immunosuppressed (IS) individuals are at high risk of severe respiratory syncytial virus (RSV) complications. This prespecified analysis of DAN-RSV evaluated the effectiveness of a bivalent RSV prefusion F protein-based vaccine …
View article: High-Dose vs Standard-Dose Influenza Vaccine in Chronic Kidney Disease
High-Dose vs Standard-Dose Influenza Vaccine in Chronic Kidney Disease Open
In this prespecified analysis of DANFLU-2, including the largest CKD population ever in an individually randomized vaccine trial, we observed a benefit of HD-IIV vs SD-IIV against hospitalization for influenza or pneumonia, as well as hosp…
Predictors of B-line count in hospitalized patients with COVID-19 Open
Background B-lines on lung ultrasound (LUS) are nonspecific signs of increased lung density, which can be secondary to pulmonary congestion, pneumonia, or fibrosis. While its use is recommended in acute heart failure (HF), its value in non…
View article: High-Dose vs Standard-Dose Influenza Vaccine and Cardiovascular Outcomes in Older Adults
High-Dose vs Standard-Dose Influenza Vaccine and Cardiovascular Outcomes in Older Adults Open
Importance The high-dose inactivated influenza vaccine (HD-IIV) has demonstrated superior protection against laboratory-confirmed influenza infection vs standard-dose IIV (SD-IIV); however, data regarding its effectiveness against cardiova…
View article: Risk of Myocarditis or Pericarditis With High-Dose vs Standard-Dose Influenza Vaccine
Risk of Myocarditis or Pericarditis With High-Dose vs Standard-Dose Influenza Vaccine Open
This prespecified secondary analysis of a randomized clinical trial investigates the risk of myocarditis or pericarditis with high-dose vs standard-dose inactivated influenza vaccine among older adults.
View article: Bivalent RSV Prefusion F Protein–Based Vaccine for Preventing Cardiovascular Hospitalizations in Older Adults
Bivalent RSV Prefusion F Protein–Based Vaccine for Preventing Cardiovascular Hospitalizations in Older Adults Open
Importance Respiratory syncytial virus (RSV) infection is linked to elevated cardiovascular risk, particularly in individuals with preexisting cardiovascular disease (CVD). A bivalent RSV prefusion F protein (RSVpreF) vaccine was recently …
Recurrent Ischemic Stroke and Vaginal Estradiol in Women With Prior Ischemic Stroke: A Nationwide Nested Case-Control Study Open
BACKGROUND: Systemic estrogen replacement therapy is contraindicated in women with a history of ischemic stroke due to the risk of stroke recurrence. There are currently no published data available describing the association between vagina…
View article: High-dose vs. standard-dose inactivated influenza vaccine and cardiovascular outcomes in persons with or without pre-existing atherosclerotic cardiovascular disease: the DANFLU-2 trial
High-dose vs. standard-dose inactivated influenza vaccine and cardiovascular outcomes in persons with or without pre-existing atherosclerotic cardiovascular disease: the DANFLU-2 trial Open
Background and Aims The aim was to evaluate and compare the relative vaccine effectiveness (rVE) of high-dose (HD-IIV) vs. standard-dose inactivated influenza vaccination (SD-IIV) on respiratory and cardiovascular outcomes in persons with …
View article: Effectiveness of bivalent respiratory syncytial virus prefusion F protein-based vaccine in individuals with or without atherosclerotic cardiovascular disease: the DAN-RSV trial
Effectiveness of bivalent respiratory syncytial virus prefusion F protein-based vaccine in individuals with or without atherosclerotic cardiovascular disease: the DAN-RSV trial Open
Background and Aims It is not known whether the bivalent respiratory syncytial virus prefusion F protein-based (RSVpreF) vaccine reduces outcomes in individuals with atherosclerotic cardiovascular disease (ASCVD). The aim was to evaluate t…
Long-term effects on cardiac function and symptoms in patients with myocarditis following COVID-19 vaccination: the ECHOVID-19 Long-term Study Open
Background The long-term effects of myocarditis following COVID-19 vaccination on cardiac function and symptoms remain unclear. Purpose To assess the long-term effects of myocarditis following COVID-19 vaccination on cardiac function, infl…
Prevalence of cardiac dysfunction in men with erectile dysfunction: the <span>EDcard</span> study Open
Objectives To assess the prevalence of myocardial impairment in men with erectile dysfunction (ED) as compared with the general population using conventional and two‐dimensional speckle‐tracking echocardiography. Subjects and Methods In th…
Educational Attainment Level and Risk of Mortality and Cardiopulmonary Outcomes in High‐Risk Patients With Cardiovascular Disease: The INVESTED Trial Open
Background Educational attainment level (EAL) is an indicator of socioeconomic status and has been shown to be inversely related with adverse health outcomes. However, the association between EAL and risk of clinical outcomes in high‐risk …
View article: Left Ventricular Ejection Fraction Reserve and Its Association with Myocardial Perfusion, Coronary Calcification, and Strain in Type 2 Diabetes Without Overt Cardiovascular Disease
Left Ventricular Ejection Fraction Reserve and Its Association with Myocardial Perfusion, Coronary Calcification, and Strain in Type 2 Diabetes Without Overt Cardiovascular Disease Open
Background: Type 2 diabetes (T2D) is a major risk factor for cardiovascular disease (CVD), but the relationships between myocardial function, microvascular function, and atherosclerotic burden remain underexplored in asymptomatic individua…
View article: A Nationwide Factorial Randomized Trial of Electronic Nudges to Patients With Chronic Kidney Disease and Their General Practices for Increasing Guideline-Directed Medical Therapy: The NUDGE-CKD Trial
A Nationwide Factorial Randomized Trial of Electronic Nudges to Patients With Chronic Kidney Disease and Their General Practices for Increasing Guideline-Directed Medical Therapy: The NUDGE-CKD Trial Open
BACKGROUND: Many individuals with chronic kidney disease (CKD) face a considerable but modifiable risk of cardiovascular and renal outcomes because of suboptimal implementation of guideline-directed medical therapy (GDMT). We investigated …
IDENTIFYING RISK FACTORS ASSOCIATED WITH CARDIAC DYSFUNCTION IN MEN WITH ERECTILE DYSFUNCTION: THE EDCARD STUDY Open
Objectives Erectile dysfunction (ED) is recognized as an early marker for cardiovascular disease yet the specific clinical characteristics that correlate with cardiac dysfunction remain unclear. We aimed to identify risk factors of cardiac…
View article: Sex differences in myocardial flow reserve among individuals with type 2 diabetes: insights from the DiaHeart study
Sex differences in myocardial flow reserve among individuals with type 2 diabetes: insights from the DiaHeart study Open
In individuals with type 2 diabetes without overt CVD, women exhibited lower MFR than men, primarily due to higher MBF at rest, suggesting sex-related differences. While MFR declined in both sexes, the sex difference was more pronounced in…
Low Vitamin K Status and Risk of Chronic Obstructive Pulmonary Disease Open
Background: Vitamin K is a cofactor necessary for the biological activity of proteins like Matrix Gla Protein (MGP), which reduce calcification and help preserve lung function. This study aims to determine, first, whether low vitamin K sta…
Cardiac Characteristics of Hospitalized Influenza Patients: An Interim Analysis From the FluHeart Study Open
Background Influenza infection has been associated with multiple cardiac complications including acute heart failure and myocardial infarction. The FluHeart study aims to uncover the potential effect of influenza infection on cardiac struc…
Cardiac power and the association with heart failure and cardiovascular death in the general population Open
During a median follow-up of 3.5 years (IQR 2.6;4.4 years), 134 (3.3 %) individuals experienced the composite outcome. Left ventricular (LV) ejection fraction (LVEF) significantly modified the association between CP and outcome (pinteracti…