Matt Bawn
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View article: Identification of multidrug-resistant monophasic Salmonella Typhimurium ST34 and other NTS from animal-environmental origins in South Africa
Identification of multidrug-resistant monophasic Salmonella Typhimurium ST34 and other NTS from animal-environmental origins in South Africa Open
View article: University staff and student perspectives on competent and ethical use of AI: uncovering similarities and divergences
University staff and student perspectives on competent and ethical use of AI: uncovering similarities and divergences Open
We investigated the similarities and differences in understanding among UK-based university staff and students regarding AI literacy, in terms of competent and ethical use of AI tools. This study builds on existing research revealing both …
View article: Identifying rare spontaneous mutations through wildtype <i>E. coli</i> population sequencing
Identifying rare spontaneous mutations through wildtype <i>E. coli</i> population sequencing Open
Understanding the rate and types of mutations occurring in different populations is fundamental to our ability to predict and potentially manipulate evolution. Common techniques for microbial mutation rate estimation fall into 2 camps; rap…
View article: Reversible excision of the wzy locus in Salmonella Typhimurium may aid recovery following phage predation
Reversible excision of the wzy locus in Salmonella Typhimurium may aid recovery following phage predation Open
Bacteriophage (phage) are promising novel antimicrobials but a key challenge to their effective implementation is the rapid emergence of phage resistance. An improved understanding of phage-host interactions is therefore needed. The Anders…
View article: Reversible excision of the<i>wzy</i>locus in<i>Salmonella</i>Typhimurium may aid recovery following phage predation
Reversible excision of the<i>wzy</i>locus in<i>Salmonella</i>Typhimurium may aid recovery following phage predation Open
Bacteriophage (phage) are promising novel antimicrobials but a key challenge to their effective implementation is the rapid emergence of phage resistance. An improved understanding of phage-host interactions is therefore needed. The Anders…
View article: Genomic analysis of clinical Aeromonas isolates reveals genetic diversity but little evidence of genetic determinants for diarrhoeal disease
Genomic analysis of clinical Aeromonas isolates reveals genetic diversity but little evidence of genetic determinants for diarrhoeal disease Open
Aeromonas spp. are associated with a number of infectious syndromes in humans including gastroenteritis and dysentery. Our understanding of the genetic diversity, population structure, virulence determinants and antimicrobial resistance of…
View article: Population structure of Salmonella enterica Typhi in Harare, Zimbabwe (2012–19) before typhoid conjugate vaccine roll-out: a genomic epidemiology study
Population structure of Salmonella enterica Typhi in Harare, Zimbabwe (2012–19) before typhoid conjugate vaccine roll-out: a genomic epidemiology study Open
Bill & Melinda Gates Foundation and the Biotechnology and Biological Sciences Research Council Institute Strategic Programme.
View article: A genomic appraisal of invasive Salmonella Typhimurium and associated antibiotic resistance in sub-Saharan Africa
A genomic appraisal of invasive Salmonella Typhimurium and associated antibiotic resistance in sub-Saharan Africa Open
View article: Highly drug resistant clone of Salmonella Kentucky ST198 in clinical infections and poultry in Zimbabwe
Highly drug resistant clone of Salmonella Kentucky ST198 in clinical infections and poultry in Zimbabwe Open
View article: Increased phage resistance through lysogenic conversion accompanying emergence of monophasic Salmonella Typhimurium ST34 pandemic strain
Increased phage resistance through lysogenic conversion accompanying emergence of monophasic Salmonella Typhimurium ST34 pandemic strain Open
Salmonella enterica serovar Typhimurium ( S . Typhimurium) comprises a group of closely related human and animal pathogens that account for a large proportion of all Salmonella infections globally. The epidemiological record of S . Typhimu…
View article: Single-cell genomics reveals population structures from in vitro evolutionary studies of Salmonella
Single-cell genomics reveals population structures from in vitro evolutionary studies of Salmonella Open
Single-cell DNA sequencing has the potential to reveal detailed hierarchical structures in evolving populations of cells. Single cell approaches are increasingly used to study clonal evolution in human ageing and cancer but have not yet be…
View article: Population structure and evolution of <i>Salmonella enterica</i> serotype Typhi in Zimbabwe before a typhoid conjugate vaccine immunization campaign
Population structure and evolution of <i>Salmonella enterica</i> serotype Typhi in Zimbabwe before a typhoid conjugate vaccine immunization campaign Open
Background The continued emergence of Salmonella enterica serovar Typhi ( S . Typhi) with ever increasing antimicrobial resistance (AMR), necessitates the use of vaccines in endemic countries. A typhoid fever outbreak in Harare, Zimbabwe i…
View article: Ten simple rules for using entrepreneurship skills to improve research careers and culture
Ten simple rules for using entrepreneurship skills to improve research careers and culture Open
The academic path is not an easy one.The acknowledgment of the problems of the research precariat [1], the lack of stability and certainty in our careers, is not a new thing.The number of permanent positions in academic research has always…
View article: Ecological niche adaptation of Salmonella Typhimurium U288 is associated with altered pathogenicity and reduced zoonotic potential
Ecological niche adaptation of Salmonella Typhimurium U288 is associated with altered pathogenicity and reduced zoonotic potential Open
View article: Whole-genome epidemiology links phage-mediated acquisition of a virulence gene to the clonal expansion of a pandemic Salmonella enterica serovar Typhimurium clone
Whole-genome epidemiology links phage-mediated acquisition of a virulence gene to the clonal expansion of a pandemic Salmonella enterica serovar Typhimurium clone Open
Epidemic and pandemic clones of bacterial pathogens with distinct characteristics continually emerge, replacing those previously dominant through mechanisms that remain poorly characterized. Here, whole-genome-sequencing-powered epidemiolo…
View article: Ecological niche adaptation of a bacterial pathogen associated with reduced zoonotic potential
Ecological niche adaptation of a bacterial pathogen associated with reduced zoonotic potential Open
The emergence of new bacterial pathogens is a continuing challenge for agriculture and food safety. Salmonella enterica serovar Typhimurium ( S . Typhimurium) is a major cause of foodborne illness worldwide, with pigs a major zoonotic rese…
View article: Bacterial single-cell genomics enables phylogenetic analysis and reveals population structures from<i>in vitro</i>evolutionary studies
Bacterial single-cell genomics enables phylogenetic analysis and reveals population structures from<i>in vitro</i>evolutionary studies Open
Single-cell DNA sequencing has the potential to reveal detailed hierarchical structures in evolving populations of cells. Single cell approaches are increasingly used to study clonal evolution in human ageing and cancer, but have not yet b…
View article: Evolution of Salmonella enterica serotype Typhimurium driven by anthropogenic selection and niche adaptation
Evolution of Salmonella enterica serotype Typhimurium driven by anthropogenic selection and niche adaptation Open
Salmonella enterica serotype Typhimurium (S. Typhimurium) is a leading cause of gastroenteritis and bacteraemia worldwide, and a model organism for the study of host-pathogen interactions. Two S. Typhimurium strains (SL1344 and ATCC14028) …
View article: Evolution of <i>Salmonella enterica</i> serotype Typhimurium driven by anthropogenic selection and niche adaptation
Evolution of <i>Salmonella enterica</i> serotype Typhimurium driven by anthropogenic selection and niche adaptation Open
Salmonella enterica serotype Typhimurium ( S . Typhimurium) is a leading cause of gastroenteritis and disseminated disease worldwide. Two S . Typhimurium strains (SL1344 and ATCC14028) are widely used to study host-pathogen interactions, y…
View article: Genome-wide Analysis of Salmonella enterica serovar Typhi in Humanized Mice Reveals Key Virulence Features
Genome-wide Analysis of Salmonella enterica serovar Typhi in Humanized Mice Reveals Key Virulence Features Open
View article: Microevolution of antimicrobial resistance and biofilm formation of Salmonella Typhimurium during persistence on pig farms
Microevolution of antimicrobial resistance and biofilm formation of Salmonella Typhimurium during persistence on pig farms Open
View article: SGI-4 in Monophasic Salmonella Typhimurium ST34 Is a Novel ICE That Enhances Resistance to Copper
SGI-4 in Monophasic Salmonella Typhimurium ST34 Is a Novel ICE That Enhances Resistance to Copper Open
A multi drug resistant Salmonella enterica 4,[5],12:i- of sequence type 34 (monophasic S. Typhimurium ST34) is a current pandemic clone associated with livestock, particularly pigs, and numerous outbreaks in the human populat…
View article: Dissemination of a phage-encoded virulence factor in a pandemic S. Typhimurium
Dissemination of a phage-encoded virulence factor in a pandemic S. Typhimurium Open
Salmonella Typhimurium is the second most common cause of foodborne salmonellosis. Phage-mediated horizontal gene transfer contributes to the virulence of S. Typhimurium. An example of a phage-encoded virulence gene is sopE, a T3SS effecto…
View article: SGI-4 in monophasic <i>Salmonella</i> Typhimurium ST34 is a novel ICE that enhances resistance to copper
SGI-4 in monophasic <i>Salmonella</i> Typhimurium ST34 is a novel ICE that enhances resistance to copper Open
A multi drug resistant (MDR) Salmonella enterica 4,[5],12:i-of sequence type 34 (monophasic S . Typhimurium ST34) is a current pandemic clone associated with livestock and numerous outbreaks in the human population. A large genomic island,…
View article: Y Chromosome Sequences Reveal a Short Beringian Standstill, Rapid Expansion, and early Population structure of Native American Founders
Y Chromosome Sequences Reveal a Short Beringian Standstill, Rapid Expansion, and early Population structure of Native American Founders Open
The Americas were the last inhabitable continents to be occupied by humans, with a growing multidisciplinary consensus for entry 15-25 thousand years ago (kya) from northeast Asia via the former Beringia land bridge [1-4]. Autosomal DNA an…
View article: Y Chromosome Sequences Reveal a Short Beringian Standstill, Rapid Expansion, and early Population structure of Native American Founders
Y Chromosome Sequences Reveal a Short Beringian Standstill, Rapid Expansion, and early Population structure of Native American Founders Open
View article: Ethnic Considerations for Glaucoma: A Review
Ethnic Considerations for Glaucoma: A Review Open
Glaucoma is undoubtedly a major worldwide disease and cause of blindness. The term glaucoma however encompasses a group of disorders with differing age of incidence, intraocular pressures and varying degrees of hereditability in which visi…
View article: Genome Variation and Molecular Epidemiology of Salmonella enterica Serovar Typhimurium Pathovariants
Genome Variation and Molecular Epidemiology of Salmonella enterica Serovar Typhimurium Pathovariants Open
Salmonella enterica serovar Typhimurium is one of approximately 2,500 distinct serovars of the genus Salmonella but is exceptional in its wide distribution in the environment, livestock, and wild animals. S .
View article: Electron Paramagnetic Resonance Investigation of Nitrite Binding in Myoglobin
Electron Paramagnetic Resonance Investigation of Nitrite Binding in Myoglobin Open
It has been proposed that myoglobin (Mb) may act as a nitrite reductase under hypoxic conditions. Any mechanism describing such activity should take into account the binding geometry of the ligand to the heme. Crystal structures of horse-h…
View article: Pulsed ELDOR Measurement of the Distance Between a Spin-Label and Copper (II) Centre in the Copper Loaded R48C Mutant of <i>N. gonorrhoeae</i> Ferric Binding Protein
Pulsed ELDOR Measurement of the Distance Between a Spin-Label and Copper (II) Centre in the Copper Loaded R48C Mutant of <i>N. gonorrhoeae</i> Ferric Binding Protein Open
Distance determination in proteins and biomolecules using pulsed EPR (electron paramagnetic resonance) techniques is becoming an increasingly popular and accessible technique. PELDOR (pulsed electron-electron double resonance), is a techni…