Matthew A. Cooper
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View article: PET-MRI biomarkers reveal efficacy of a novel NLRP3 inhibitor in Parkinson’s disease models
PET-MRI biomarkers reveal efficacy of a novel NLRP3 inhibitor in Parkinson’s disease models Open
Parkinson’s disease is one of the fastest-growing neurodegenerative disorders, with no effective treatments to modify its progression. Microglial-driven neuroinflammation, mediated by NLRP3 inflammasome activation, plays a key role in dise…
View article: Paraquat Licences α-Synuclein to Trigger NLRP3-Dependent Pyroptosis in Microglia
Paraquat Licences α-Synuclein to Trigger NLRP3-Dependent Pyroptosis in Microglia Open
Parkinson’s disease (PD) is characterized by dopaminergic neurodegeneration and the pathological accumulation of α-synuclein (αSyn) aggregates. While its etiology is multifactorial, environmental toxicants such as paraquat, a widely used h…
View article: Antibiotics re-booted—time to kick back against drug resistance
Antibiotics re-booted—time to kick back against drug resistance Open
After decades of neglect and a decline in antibiotic research and development, we are now finally witnessing the advent of new funding programs dedicated to new therapies. In addition to traditional new chemical entities that directly kill…
View article: Characterisation of <i>in vitro</i> resistance selection against second-/last-line antibiotics in methicillin-resistant <i>Staphylococcus aureus</i> ATCC 43300 strain
Characterisation of <i>in vitro</i> resistance selection against second-/last-line antibiotics in methicillin-resistant <i>Staphylococcus aureus</i> ATCC 43300 strain Open
Background and objectives The increasing occurrence of MRSA clinical isolates harbouring reduced susceptibility to mainstay antibiotics has escalated the use of second and last line antibiotics. Hence, it is critical to evaluate the likeli…
View article: Characterisation of <i>in vitro</i> resistance selection against second-/last-line antibiotics in methicillin-resistant <i>Staphylococcus aureus</i>
Characterisation of <i>in vitro</i> resistance selection against second-/last-line antibiotics in methicillin-resistant <i>Staphylococcus aureus</i> Open
SYNOPSIS Background The increasing occurrence of MRSA clinical isolates harbouring reduced susceptibility to mainstay antibiotics has escalated the use of second and last line antibiotics. Hence, it is critical to evaluate the likelihood o…
View article: Fecal microbial transfer and complex carbohydrates mediate protection against COPD
Fecal microbial transfer and complex carbohydrates mediate protection against COPD Open
Objective Chronic obstructive pulmonary disease (COPD) is a major cause of global illness and death, most commonly caused by cigarette smoke. The mechanisms of pathogenesis remain poorly understood, limiting the development of effective th…
View article: Impact of the new membrane-targeting lipoglycopeptide antibiotic MCC5145 on the treatment of bacteremic pneumococcal pneumonia in mice
Impact of the new membrane-targeting lipoglycopeptide antibiotic MCC5145 on the treatment of bacteremic pneumococcal pneumonia in mice Open
Bacteremic Streptococcus pneumoniae pneumonia is one of the most severe forms of invasive pneumococcal disease (IPD) and with particularly high case-fatality rates among the elderly and individuals with comorbidities, exacerbated by rising…
View article: Purification of PaTx-II from the Venom of the Australian King Brown Snake and Characterization of Its Antimicrobial and Wound Healing Activities
Purification of PaTx-II from the Venom of the Australian King Brown Snake and Characterization of Its Antimicrobial and Wound Healing Activities Open
Infections caused by multi-drug-resistant (MDR) bacteria are a global threat to human health. As venoms are the source of biochemically diverse bioactive proteins and peptides, we investigated the antimicrobial activity and murine skin inf…
View article: CoviRx: A User-Friendly Interface for Systematic Down-Selection of Repurposed Drug Candidates for COVID-19
CoviRx: A User-Friendly Interface for Systematic Down-Selection of Repurposed Drug Candidates for COVID-19 Open
Although various vaccines are now commercially available, they have not been able to stop the spread of COVID-19 infection completely. An excellent strategy to get safe, effective, and affordable COVID-19 treatments quickly is to repurpose…
View article: 195 Characterization of WU-NK-101, a feeder cell-free expanded allogeneic memory NK cell product with potent anti-tumor activity
195 Characterization of WU-NK-101, a feeder cell-free expanded allogeneic memory NK cell product with potent anti-tumor activity Open
Background Cytokine-induced memory NK cells, like WU-NK-101, offer several advantages over conventional NK cells.1, 2 These advantages include enhanced functional persistence, efficacy, and metabolic fitness that improve their survival and…
View article: Topological relationships-based flow direction modeling: mesh-independent river networks representation
Topological relationships-based flow direction modeling: mesh-independent river networks representation Open
River networks are important features in surface hydrology. However, accurately representing river networks in spatially distributed hydrologic and Earth system models is often sensitive to the model’s spatial resolution. Specifically, riv…
View article: Systematic Down-Selection of Repurposed Drug Candidates for COVID-19
Systematic Down-Selection of Repurposed Drug Candidates for COVID-19 Open
SARS-CoV-2 is the cause of the COVID-19 pandemic which has claimed more than 6.5 million lives worldwide, devastating the economy and overwhelming healthcare systems globally. The development of new drug molecules and vaccines has played a…
View article: Metal Complexes as Antifungals? From a Crowd-Sourced Compound Library to the First <i>In Vivo</i> Experiments
Metal Complexes as Antifungals? From a Crowd-Sourced Compound Library to the First <i>In Vivo</i> Experiments Open
There are currently fewer than 10 antifungal drugs in clinical development, but new fungal strains that are resistant to most current antifungals are spreading rapidly across the world. To prevent a second resistance crisis, new classes of…
View article: CoviRx: A User-Friendly Interface for Systematic Down-Selection of Repurposed Drug Candidates for COVID-19
CoviRx: A User-Friendly Interface for Systematic Down-Selection of Repurposed Drug Candidates for COVID-19 Open
Although various vaccines are now commercially available, they have not been able to stop the spread of COVID-19 infection completely. An excellent strategy to quickly get safe, effective, and affordable COVID-19 treatment is to repurpose …
View article: Systematic Down-Selection of Repurposed Drug Candidates for COVID-19
Systematic Down-Selection of Repurposed Drug Candidates for COVID-19 Open
SARS-CoV-2, is the cause of the COVID-19 pandemic which has claimed more than six million lives worldwide, devastating the economy and overwhelming healthcare systems globally. The development of new drug molecules and vaccines has played …
View article: Metal Complexes as Antifungals? – From a Crowd-Sourced Compound Library to First In Vivo Experiments
Metal Complexes as Antifungals? – From a Crowd-Sourced Compound Library to First In Vivo Experiments Open
There are currently fewer than ten antifungal drugs in clinical development, but new fungal strains, which are resistant to most current antifungals are spreading rapidly across the world. To prevent a second resistance crisis, new classes…
View article: Investigations into the membrane activity of arenicin antimicrobial peptide AA139
Investigations into the membrane activity of arenicin antimicrobial peptide AA139 Open
Arenicin-3 is an amphipathic β-hairpin antimicrobial peptide that is produced by the lugworm Arenicola marina. In this study, we have investigated the mechanism of action of arenicin-3 and an optimized synthetic analogue, AA139, by studyin…
View article: Nitroimidazopyrazinones with oral activity against tuberculosis and Chagas disease in mouse models of infection
Nitroimidazopyrazinones with oral activity against tuberculosis and Chagas disease in mouse models of infection Open
Tuberculosis remains one of the leading causes of death from a single infectious agent, surpassing both AIDS and malaria. In recent years, two bicyclic nitroimidazole drugs, delamanid and pretomanid have been approved to treat this airborn…
View article: Amino Alcohols as Potential Antibiotic and Antifungal Leads
Amino Alcohols as Potential Antibiotic and Antifungal Leads Open
Five focused compound libraries (forty-nine compounds), based on prior studies in our laboratory were synthesized and screened for antibiotic and anti-fungal activity against S. aureus, E. coli, K. pneumoniae, P. aeruginosa, A. baumannii, …
View article: Aim2 suppresses cigarette smoke‐induced neutrophil recruitment, neutrophil caspase‐1 activation and anti‐Ly6G‐mediated neutrophil depletion
Aim2 suppresses cigarette smoke‐induced neutrophil recruitment, neutrophil caspase‐1 activation and anti‐Ly6G‐mediated neutrophil depletion Open
Increased inflammasome responses are strongly implicated in inflammatory diseases; however, their specific roles are incompletely understood. Therefore, we sought to examine the roles of nucleotide‐binding oligomerization domain–like recep…
View article: Interleukin-1β suppression dampens inflammatory leucocyte production and uptake in atherosclerosis
Interleukin-1β suppression dampens inflammatory leucocyte production and uptake in atherosclerosis Open
Aims Targeting vascular inflammation represents a novel therapeutic approach to reduce complications of atherosclerosis. Neutralizing the pro-inflammatory cytokine interleukin-1β (IL-1β) using canakinumab, a monoclonal antibody, reduces th…
View article: Mesoporous Silica Nanoparticles Improve Oral Delivery of Antitubercular Bicyclic Nitroimidazoles
Mesoporous Silica Nanoparticles Improve Oral Delivery of Antitubercular Bicyclic Nitroimidazoles Open
Pretomanid and MCC7433, a novel nitroimidazopyrazinone analog, are promising antitubercular agents that belong to the bicyclic nitroimidazole family. Despite possessing high cell permeability, they suffer from poor aqueous solubility and r…
View article: Pharmacological Inhibition of the Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome with MCC950
Pharmacological Inhibition of the Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome with MCC950 Open
Activation of the Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome drives release of the proinflammatory cytokines interleukin (IL)-1β and IL-18 and induces pyroptosis (lytic cell death). These events drive chronic i…
View article: <i>In Vitro</i> Activity of Vancapticin MCC5145 against Methicillin-Resistant Staphylococcus aureus from Periprosthetic Joint Infection
<i>In Vitro</i> Activity of Vancapticin MCC5145 against Methicillin-Resistant Staphylococcus aureus from Periprosthetic Joint Infection Open
MRSA periprosthetic 1 joint infection (PJI) can be challenging to treat due to biofilm formation, alongside sometimes limited vancomycin activity (1-3).….