Matt Vassar
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View article: Reporting and methodological quality of systematic reviews underpinning clinical practice guidelines for low back pain: a meta-epidemiological study
Reporting and methodological quality of systematic reviews underpinning clinical practice guidelines for low back pain: a meta-epidemiological study Open
Background Low back pain (LBP) is the leading musculoskeletal disorder worldwide and a major cause of disability, health care utilization, and economic burden. Clinical practice guidelines (CPGs) aim to optimize care but depend heavily on …
View article: Supplementary Figure S1 from Assessing Patient Risk, Benefit, and Outcomes in Drug Development: A Decade of Dabrafenib and Trametinib Clinical Trials
Supplementary Figure S1 from Assessing Patient Risk, Benefit, and Outcomes in Drug Development: A Decade of Dabrafenib and Trametinib Clinical Trials Open
Supplementary Figure S1: Flow diagram for study inclusion.
View article: Supplementary Table S1 from Assessing Patient Risk, Benefit, and Outcomes in Drug Development: A Decade of Dabrafenib and Trametinib Clinical Trials
Supplementary Table S1 from Assessing Patient Risk, Benefit, and Outcomes in Drug Development: A Decade of Dabrafenib and Trametinib Clinical Trials Open
Supplementary Table S1: Clinical Trial Publications With Multiple Indications
View article: Data from Assessing Patient Risk, Benefit, and Outcomes in Drug Development: A Decade of Dabrafenib and Trametinib Clinical Trials
Data from Assessing Patient Risk, Benefit, and Outcomes in Drug Development: A Decade of Dabrafenib and Trametinib Clinical Trials Open
Dabrafenib and trametinib (D&T) received accelerated approval by the FDA in 2022 for the treatment of metastatic solid tumors harboring BRAF mutations. Our aim was to evaluate the risk/benefit profile of D&T in clinical trials. A comprehen…
View article: Investigating Recruitment and Retention Strategies in Atopic Dermatitis Clinical Trials: A Cross-Sectional Analysis (Preprint)
Investigating Recruitment and Retention Strategies in Atopic Dermatitis Clinical Trials: A Cross-Sectional Analysis (Preprint) Open
BACKGROUND AD is a chronic and relapsing inflammatory dermatologic condition marked by erythematous, pruritic lesions. Multiple factors like psychological stress, lifestyle factors, and socioeconomic determinants influence disease progres…
View article: Reporting of harms in systematic reviews focused on naltrexone: a cross-sectional study
Reporting of harms in systematic reviews focused on naltrexone: a cross-sectional study Open
Background Naltrexone is a pharmacological intervention widely used for alcohol use disorder (AUD), opioid use disorder (OUD), and several off-label conditions. Systematic reviews (SRs) play a critical role in synthesizing data on the effi…
View article: Adherence to CONSORT-PRO Extension Guidelines for Patient-Reported Outcomes in Randomized Controlled Trials Focused on Peripheral Nerve Blocks: A Meta-epidemiological Study
Adherence to CONSORT-PRO Extension Guidelines for Patient-Reported Outcomes in Randomized Controlled Trials Focused on Peripheral Nerve Blocks: A Meta-epidemiological Study Open
View article: Incomplete harms reporting in systematic reviews of direct oral factor Xa inhibitors
Incomplete harms reporting in systematic reviews of direct oral factor Xa inhibitors Open
View article: Rates of discontinuation and non‐publication of regional anaesthesia clinical trials: a registry‐based cross‐sectional analysis
Rates of discontinuation and non‐publication of regional anaesthesia clinical trials: a registry‐based cross‐sectional analysis Open
View article: Bridging Evidence and Practice – Assessing the Usefulness of Randomized Controlled Trials in PCOS Related Infertility Published 2014–2024: A Systematic Review
Bridging Evidence and Practice – Assessing the Usefulness of Randomized Controlled Trials in PCOS Related Infertility Published 2014–2024: A Systematic Review Open
View article: Balancing Reimbursement and Safety: The Anthem Blue Cross Blue Shield Policy Shift and Its Impact on Anesthesia Care
Balancing Reimbursement and Safety: The Anthem Blue Cross Blue Shield Policy Shift and Its Impact on Anesthesia Care Open
View article: Medicare Savings for Seizure Drugs by Adopting the Mark Cuban Cost Plus Drug Company Model
Medicare Savings for Seizure Drugs by Adopting the Mark Cuban Cost Plus Drug Company Model Open
Our study highlights the potential savings with MCCPDC, especially among the 90ct medications, demonstrating that a cheaper alternative to chronic medications is possible if the pricing of MCCPDC is used. We recommend that physicians educa…
View article: Data sharing statements: impact of journal policies across clinical research disciplines
Data sharing statements: impact of journal policies across clinical research disciplines Open
Background and Aims Cardiovascular disease is a leading cause of mortality, with significant investments in research to improve treatment and prevention. Data sharing enhances transparency, reproducibility, and collaboration, yet data shar…
View article: The usefulness of orthopedic shoulder surgery randomized controlled trials: are they meeting the key criteria?
The usefulness of orthopedic shoulder surgery randomized controlled trials: are they meeting the key criteria? Open
View article: Endorsement of reporting guidelines and clinical trial registration by tropical medicine and infectious disease journals: A cross‐sectional study
Endorsement of reporting guidelines and clinical trial registration by tropical medicine and infectious disease journals: A cross‐sectional study Open
Background Studies published in academic medical journals inform and influence healthcare decisions. Sufficient study reporting is primarily charged to researchers. However, journals can promote more complete reporting of their published s…
View article: A cross-sectional study on the endorsement of reporting guidelines and clinical trial registration among immunology and allergy journals
A cross-sectional study on the endorsement of reporting guidelines and clinical trial registration among immunology and allergy journals Open
Background Healthcare practitioners rely on research based on solid evidence for their clinical decisions, ensuring the provision of safe and effective patient care. The use of reporting guidelines and the registration of clinical trials e…
View article: An evaluation of selinexor’s clinical trial portfolio: a cross-sectional study
An evaluation of selinexor’s clinical trial portfolio: a cross-sectional study Open
Background: Cancer drug development is a complex and costly process. Selinexor is a drug that received accelerated approval as a new treatment for relapsed or refractory diffuse-large B-cell lymphoma and multiple myeloma. Despite initially…
View article: The State of Data Sharing in Plastic Surgery: An Analysis of Journal Practices and Author Adherence
The State of Data Sharing in Plastic Surgery: An Analysis of Journal Practices and Author Adherence Open
Background: Data sharing is crucial for transparency and reproducibility in research. We aim to evaluate data sharing practices in plastic surgery research, focusing on data sharing statements (DSSs), identifying key trends, and assessing …
View article: Recruitment and Retention Strategies in Clinical Trials for Hip Fractures: A Cross-Sectional Analysis
Recruitment and Retention Strategies in Clinical Trials for Hip Fractures: A Cross-Sectional Analysis Open
Objective: To investigate the recruitment and retention strategies in clinical trials evaluating hip fractures, with a focus on underrepresented populations. Background: The prevalence and burden of hip fractures necessitate diverse and re…
View article: Publication Bias in Leading Anesthesiology Journals: A Systematic Review
Publication Bias in Leading Anesthesiology Journals: A Systematic Review Open
View article: Lowering pain and inflammation drug costs: evaluating the impact of a cost plus drug company model
Lowering pain and inflammation drug costs: evaluating the impact of a cost plus drug company model Open
View article: Assessing the prevalence, quality and compliance of data-sharing statements in gastroenterology publications: a cross-sectional analysis
Assessing the prevalence, quality and compliance of data-sharing statements in gastroenterology publications: a cross-sectional analysis Open
Objective To examine the current state of data-sharing practices in gastroenterology literature, focusing on data-sharing statements (DSS) and identifying influential factors on DSS inclusion. Background High-quality, reproducible research…
View article: Assessing patient risk, benefit, and outcomes in drug development: a decade of vemurafenib clinical trials
Assessing patient risk, benefit, and outcomes in drug development: a decade of vemurafenib clinical trials Open
Background Vemurafenib (Zelboraf®, Roche), approved by the FDA in 2011 for unresectable and metastatic melanoma and Erdheim-Chester Disease, has been explored in trials for other BRAF-mutated cancers. Despite 12 years of clinical use, the …
View article: Assessing the uptake of the core outcome set in randomized controlled trials for coronary artery disease: a trial registry analysis
Assessing the uptake of the core outcome set in randomized controlled trials for coronary artery disease: a trial registry analysis Open
Despite its publication in 2015, CAD COS uptake remains limited, with no significant changes in adherence over time. Barriers such as limited dissemination, lack of trialist awareness, and preferences for custom outcomes likely contribute …
View article: A scoping review evaluating health inequities in atopic dermatitis
A scoping review evaluating health inequities in atopic dermatitis Open
View article: Examining Recruitment and Retention Strategies in Hidradenitis Suppurativa Clinical Trials: A Cross‐Sectional Study
Examining Recruitment and Retention Strategies in Hidradenitis Suppurativa Clinical Trials: A Cross‐Sectional Study Open
Background: To ensure equitable and successful treatment outcomes for hidradenitis suppurativa (HS), the recruitment and retention of diverse participants in clinical trials is critical. However, current approaches may neglect under‐repres…
View article: Endorsement of Reporting Guidelines and Clinical Trial Registration by Transplantation Journals: A Cross-Sectional Review
Endorsement of Reporting Guidelines and Clinical Trial Registration by Transplantation Journals: A Cross-Sectional Review Open
View article: Endorsement of reporting guidelines and clinical trial registration across urological medical journals: a cross-sectional study
Endorsement of reporting guidelines and clinical trial registration across urological medical journals: a cross-sectional study Open
Introduction Over the years, funding for urologic diseases has witnessed a steady rise, reaching $587 million in 2020 from $541 million in 2018. In parallel, there has been a notable increase in the total number of urology journals from 20…
View article: Assessing Patient Risk, Benefit, and Outcomes in Drug Development: A Decade of Abiraterone Clinical Trials
Assessing Patient Risk, Benefit, and Outcomes in Drug Development: A Decade of Abiraterone Clinical Trials Open
Purpose: Our study aimed to evaluate the risk and benefit profiles of clinical trials using abiraterone in cancer treatment.Materials and Methods: A comprehensive search was conducted on May 24, 2023, using databases such as PubMed, Embase…
View article: Recruitment and Retention Strategies for Historically Marginalized Populations in Colorectal Cancer Trials: A Cross-Sectional Analysis Using Systematic Review Methods
Recruitment and Retention Strategies for Historically Marginalized Populations in Colorectal Cancer Trials: A Cross-Sectional Analysis Using Systematic Review Methods Open