Matteo Guidetti
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View article: Electric Field-Induced Destabilization and Surface Modulation of Aβ42 Fibrils in Molecular Simulations: Theoretical Implications for DC Stimulation in Alzheimer’s Disease
Electric Field-Induced Destabilization and Surface Modulation of Aβ42 Fibrils in Molecular Simulations: Theoretical Implications for DC Stimulation in Alzheimer’s Disease Open
The amyloid-β peptide 42 (Aβ42) forms fibrillar aggregates that are a hallmark of Alzheimer’s disease. While recent pharmacologic therapeutic strategies targeting Aβ42 fibrils and oligomers have shown promising results, safer and more effe…
View article: Direct Current (DC)-induced modulation of lipid metabolism and intercellular vesicular trafficking on a neuroblastoma in vitro model: implications for Parkinson’s disease
Direct Current (DC)-induced modulation of lipid metabolism and intercellular vesicular trafficking on a neuroblastoma in vitro model: implications for Parkinson’s disease Open
View article: Large Language Models in Neurological Practice: Real-World Study
Large Language Models in Neurological Practice: Real-World Study Open
Background Large language models (LLMs) such as ChatGPT (OpenAI) and Gemini (Google) are increasingly explored for their potential in medical diagnostics, including neurology. Their real-world applicability remains inadequately assessed, p…
View article: Will adaptive deep brain stimulation for Parkinson’s disease become a real option soon? A Delphi consensus study
Will adaptive deep brain stimulation for Parkinson’s disease become a real option soon? A Delphi consensus study Open
View article: Is physical therapy recommended for people with parkinson’s disease treated with subthalamic deep brain stimulation? a delphi consensus study
Is physical therapy recommended for people with parkinson’s disease treated with subthalamic deep brain stimulation? a delphi consensus study Open
View article: The “Cocombola Study”: A Physical Phantom Model for tDCS-Induced Electric Field Distribution
The “Cocombola Study”: A Physical Phantom Model for tDCS-Induced Electric Field Distribution Open
Background: Transcranial direct current stimulation (tDCS)-induced electric fields (EFs) acting on brain tissues are hardly controllable. Among physical models used in neuroscience research, watermelons are known as head-like phantoms for …
View article: Is it time for the neurologist to use Large Language Models in everyday practice? (Preprint)
Is it time for the neurologist to use Large Language Models in everyday practice? (Preprint) Open
BACKGROUND Large Language Models (LLMs) such as ChatGPT and Gemini are increasingly explored for their potential in medical diagnostics, including neurology. Their real-world applicability remains inadequately assessed, particularly in cl…
View article: Is it time for the neurologist to use Large Language Models in everyday practice?
Is it time for the neurologist to use Large Language Models in everyday practice? Open
Large Language Models (LLMs) such as ChatGPT and Gemini are gaining momentum in healthcare for their diagnostic potential. However, their real-world applicability in specialized medical fields like neurology remains inadequately explored. …
View article: Invasive and Non-Invasive Brain Stimulation: Neuroprotection, Lysosomal Pathways, and a Novel Invertebrate Model for Neurodegenerative Research
Invasive and Non-Invasive Brain Stimulation: Neuroprotection, Lysosomal Pathways, and a Novel Invertebrate Model for Neurodegenerative Research Open
View article: Electric Fields Induced in the Brain by Transcranial Electric Stimulation: A Review of In Vivo Recordings
Electric Fields Induced in the Brain by Transcranial Electric Stimulation: A Review of In Vivo Recordings Open
View article: Are Beta Oscillations Still a Reliable Biomarker? A 25-Year Perspective from Acute to Chronic DBS Patients
Are Beta Oscillations Still a Reliable Biomarker? A 25-Year Perspective from Acute to Chronic DBS Patients Open
View article: Physical therapy in patients with Parkinson’s disease treated with Deep Brain Stimulation: a Delphi panel study
Physical therapy in patients with Parkinson’s disease treated with Deep Brain Stimulation: a Delphi panel study Open
Although deep brain stimulation of the subthalamic nucleus (STN-DBS) induces motor benefits in people with Parkinson’s disease (PwPD), the size and duration of the effects of STN-DBS on motor axial (e.g., postural instability, trunk postur…
View article: ‘Knock down the brain’: a nonlinear analysis of electroencephalography to study the effects of sub‐concussion in boxers
‘Knock down the brain’: a nonlinear analysis of electroencephalography to study the effects of sub‐concussion in boxers Open
Background and purpose Boxing is associated with a high risk of head injuries and increases the likelihood of chronic traumatic encephalopathy. This study explores the effects of sub‐concussive impacts on boxers by applying both linear and…
View article: Adaptive Deep Brain Stimulation in Parkinson’s Disease: A Delphi Consensus Study
Adaptive Deep Brain Stimulation in Parkinson’s Disease: A Delphi Consensus Study Open
Importance If history teaches, as cardiac pacing moved from fixed-rate to on-demand delivery in in 80s of the last century, there are high probabilities that closed-loop and adaptive approaches will become, in the next decade, the natural …
View article: Asymmetries of the subthalamic activity in Parkinson’s disease: phase-amplitude coupling among local field potentials
Asymmetries of the subthalamic activity in Parkinson’s disease: phase-amplitude coupling among local field potentials Open
The role of brain asymmetries of dopaminergic neurons in motor symptoms of Parkinson’s disease is still undefined. Local field recordings from the subthalamic nucleus revealed some neurophysiological biomarkers of the disease: increased be…
View article: Lessons on neurodegeneration and aging from the Lagoon of Venice: the marine invertebrate <i>Botryllus schlosseri</i>
Lessons on neurodegeneration and aging from the Lagoon of Venice: the marine invertebrate <i>Botryllus schlosseri</i> Open
In this work, the authors proposed a novel and interesting animal model for studying human neurodegenerative diseases, Botryllus schlosseri, a small invertebrate inhabiting temperate seas worldwide, which shares remarkable similarities wit…
View article: Monopolar tDCS might affect brainstem reflexes: A computational and neurophysiological study
Monopolar tDCS might affect brainstem reflexes: A computational and neurophysiological study Open
View article: Anti-inflammatory Effects of Topical Hypericum perforatum: A Systematic Review
Anti-inflammatory Effects of Topical Hypericum perforatum: A Systematic Review Open
Introduction: Many inflammatory conditions directly impact the skin through different pathways, the understanding of which should be a priority to develop new medications to treat patients suffering from these conditions. Some studies have…
View article: Modeling Electric Fields in Transcutaneous Spinal Direct Current Stimulation: A Clinical Perspective
Modeling Electric Fields in Transcutaneous Spinal Direct Current Stimulation: A Clinical Perspective Open
Clinical findings suggest that transcutaneous spinal direct current stimulation (tsDCS) can modulate ascending sensitive, descending corticospinal, and segmental pathways in the spinal cord (SC). However, several aspects of the stimulation…
View article: Multiple Forms of Neural Cell Death in the Cyclical Brain Degeneration of A Colonial Chordate
Multiple Forms of Neural Cell Death in the Cyclical Brain Degeneration of A Colonial Chordate Open
Human neuronal loss occurs through different cellular mechanisms, mainly studied in vitro. Here, we characterized neuronal death in B. schlosseri, a marine colonial tunicate that shares substantial genomic homology with mammals and has a l…
View article: Monopolar transcranial direct current stimulation (tDCS) might selectively affect brainstem reflex pathways: a computational and neurophysiological study.
Monopolar transcranial direct current stimulation (tDCS) might selectively affect brainstem reflex pathways: a computational and neurophysiological study. Open
Non-invasive deep brain stimulation is a novel field of research that aims to affect deep brain regions’ activity through non-invasive stimulation. Recent computational and clinical findings have fostered the interest on transcranial direc…
View article: Not myopathic, but autonomic changes in patients with long-COVID syndrome: a case series
Not myopathic, but autonomic changes in patients with long-COVID syndrome: a case series Open
View article: The Effects of a New Integrated and Multidisciplinary Cognitive Rehabilitation Program Based on Mindfulness and Reminiscence Therapy in Patients with Parkinson’s Disease and Mild Cognitive Impairment: A Pilot Study
The Effects of a New Integrated and Multidisciplinary Cognitive Rehabilitation Program Based on Mindfulness and Reminiscence Therapy in Patients with Parkinson’s Disease and Mild Cognitive Impairment: A Pilot Study Open
Background: Mindfulness trainings have shown promising results as treatment for behavioural symptoms in several pathologies. In addition, mindfulness protocols induced an improvement in memory and attention. Therefore, mindfulness could be…
View article: Relationship between Reaction Times and Post-COVID-19 Symptoms Assessed by a Web-Based Visual Detection Task
Relationship between Reaction Times and Post-COVID-19 Symptoms Assessed by a Web-Based Visual Detection Task Open
Long-COVID is a clinical condition in which patients affected by SARS-CoV-2 usually report a wide range of physical and cognitive symptoms from 3 to 6 months after the infection recovery. The aim of the current study was to assess the link…
View article: Effects of Cerebellar Transcranial Direct Current Stimulation on shape recognition and mental rotation
Effects of Cerebellar Transcranial Direct Current Stimulation on shape recognition and mental rotation Open
View article: Modelling novel tDCS settings for interfering with the brainstem activity
Modelling novel tDCS settings for interfering with the brainstem activity Open
View article: Neuroprotection and Non-Invasive Brain Stimulation: Facts or Fiction?
Neuroprotection and Non-Invasive Brain Stimulation: Facts or Fiction? Open
Non-Invasive Brain Stimulation (NIBS) techniques, such as transcranial Direct Current Stimulation (tDCS) and repetitive Magnetic Transcranial Stimulation (rTMS), are well-known non-pharmacological approaches to improve both motor and non-m…
View article: Electric Fields Induced in the Brain by Transcranial Electric Stimulation: A Review of In Vivo Recordings
Electric Fields Induced in the Brain by Transcranial Electric Stimulation: A Review of In Vivo Recordings Open
Transcranial electrical stimulation (tES) techniques, such as direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS), cause neurophysiological and behavioral modifications as responses to the electric fie…
View article: Consensus Paper: Novel Directions and Next Steps of Non-invasive Brain Stimulation of the Cerebellum in Health and Disease
Consensus Paper: Novel Directions and Next Steps of Non-invasive Brain Stimulation of the Cerebellum in Health and Disease Open
View article: Effects of cerebellar tDCS on glycometabolic control
Effects of cerebellar tDCS on glycometabolic control Open