Matteo Mari
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View article: Targeting monocarboxylate transporter 1 with a copper-chelating coumarin-based bioconjugate: Synthesis and characterization
Targeting monocarboxylate transporter 1 with a copper-chelating coumarin-based bioconjugate: Synthesis and characterization Open
Monocarboxylate Transporters (MCTs), particularly MCT1, are increasingly recognized as key regulators of cancer metabolism, facilitating lactate exchange and contributing to tumor aggressiveness. Their overexpression in various malignancie…
View article: Thwarting Isomerization through Rigidity: A Promising HBED Derivative for the Chelation of Gallium-68
Thwarting Isomerization through Rigidity: A Promising HBED Derivative for the Chelation of Gallium-68 Open
The hexadentate acyclic ligand, N,N'-di(2-hydroxybenzyl)-(1,2-cyclohexanediamine)-N,N'-diacetic acid (HBCD) designed for the chelation of the positron-emitting radiometal 68Ga was developed by replacing the flexible ethylenediam…
View article: Bridging pyrimidine hemicurcumin and Cisplatin: Synthesis, coordination chemistry, and in vitro activity assessment of a novel Pt(II) complex
Bridging pyrimidine hemicurcumin and Cisplatin: Synthesis, coordination chemistry, and in vitro activity assessment of a novel Pt(II) complex Open
In the upcoming decades, the incidence and mortality rates of cancer are expected to rise globally, with colorectal and prostate cancers among the most prevalent types. Despite advancements in molecular targeted therapy, platinum-based che…
View article: Development of Stable Amino-Pyrimidine–Curcumin Analogs: Synthesis, Equilibria in Solution, and Potential Anti-Proliferative Activity
Development of Stable Amino-Pyrimidine–Curcumin Analogs: Synthesis, Equilibria in Solution, and Potential Anti-Proliferative Activity Open
With the clear need for better cancer treatment, naturally occurring molecules represent a powerful inspiration. Recently, curcumin has attracted attention for its pleiotropic anticancer activity in vitro, especially against colorectal and…
View article: Radiolabeled Chalcone Derivatives as Potential Radiotracers for β-Amyloid Plaques Imaging
Radiolabeled Chalcone Derivatives as Potential Radiotracers for β-Amyloid Plaques Imaging Open
Natural products often provide a pool of pharmacologically relevant precursors for the development of various drug-related molecules. In this review, the research performed on some radiolabeled chalcone derivatives characterized by the pre…
View article: Curcumin-Based β-Diketo Ligands for Ga3+: Thermodynamic Investigation of Potential Metal-Based Drugs
Curcumin-Based β-Diketo Ligands for Ga3+: Thermodynamic Investigation of Potential Metal-Based Drugs Open
Curcumin is known for its therapeutic properties; among these, antioxidant, anti-inflammatory and anti-cancer ones stand out. Besides, curcumin metal complexes have shown widespread application in medicine and can be exploited as lead stru…
View article: Applications of Radiolabelled Curcumin and Its Derivatives in Medicinal Chemistry
Applications of Radiolabelled Curcumin and Its Derivatives in Medicinal Chemistry Open
Curcumin is a natural occurring molecule that has aroused much interest among researchers over the years due to its pleiotropic set of biological properties. In the nuclear medicine field, radiolabelled curcumin and curcumin derivatives ha…