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View article: Infective endocarditis meets native vertebral osteomyelitis: a mortality perspective
Infective endocarditis meets native vertebral osteomyelitis: a mortality perspective Open
Background: Native vertebral osteomyelitis and infective endocarditis (NVO + IE) are increasingly recognized as overlapping entities, sharing common risk factors (e.g., advanced age, immunosuppression) and similar pathogen profiles, most c…
View article: Association of incident dialysis modality with patient survival: a systematic review and meta-analysis
Association of incident dialysis modality with patient survival: a systematic review and meta-analysis Open
Background Although the choice of dialysis technique is based on several factors, patient survival is undoubtedly one of the most relevant. In a context where randomization to either peritoneal dialysis (PD) or hemodialysis (HD) proved to …
View article: Use of a molecular syndromic panel for the etiological diagnosis of ventilator-associated bacterial pneumonia: impact on clinical outcomes and antibiotic use from a multicenter, prospective study
Use of a molecular syndromic panel for the etiological diagnosis of ventilator-associated bacterial pneumonia: impact on clinical outcomes and antibiotic use from a multicenter, prospective study Open
View article: Application of Artificial Intelligence in Inborn Errors of Immunity Identification and Management: Past, Present, and Future—A Systematic Review
Application of Artificial Intelligence in Inborn Errors of Immunity Identification and Management: Past, Present, and Future—A Systematic Review Open
Background: Inborn errors of immunity (IEI) are mainly genetically driven disorders that affect immune function and present with highly heterogeneous clinical manifestations, ranging from severe combined immunodeficiency (SCID) to adult-on…
View article: The impact of SARS-CoV-2 VOCs on clinical outcomes: an overview of reviews
The impact of SARS-CoV-2 VOCs on clinical outcomes: an overview of reviews Open
Background Synthesizing data from existing literature is crucial for validating the robustness of associations, assessing data quality, and forming recommendations, especially given the vast amount of information available on SARS-CoV-2. T…
View article: Proactive Therapeutic Drug MONiToring to Guide Suppressive Antibiotic Therapy with DALBAvaNcin ( > 12 weeks) in Osteoarticular Infections (MONTALBANO)
Proactive Therapeutic Drug MONiToring to Guide Suppressive Antibiotic Therapy with DALBAvaNcin ( > 12 weeks) in Osteoarticular Infections (MONTALBANO) Open
Introduction: Long-term dalbavancin use is increasingly adopted off-label for osteoarticular infections (OAIs), but data on administration timing and long-term effects beyond 12 weeks are scarce. This study evaluated the pharmacological ef…
View article: Association of Incident Dialysis Modality With Patient Survival: A Systematic Review and Meta-analysis
Association of Incident Dialysis Modality With Patient Survival: A Systematic Review and Meta-analysis Open
Background Although the choice of dialysis technique is based on several factors, patient survival is undoubtedly one of the most relevant. In a context where randomization to either peritoneal dialysis (PD) or hemodialysis (HD) proved to …
View article: P-1916. The impact of SARS-CoV-2 VOCs on clinical outcomes: an Umbrella Review
P-1916. The impact of SARS-CoV-2 VOCs on clinical outcomes: an Umbrella Review Open
Background Studies aiming to synthetize data from literature are helpful to valid the robustness of associations, to assess the quality of the data, and, eventually, to propose recommendations. This is particularly evident for the huge amo…
View article: Secondary anti‐viral prophylaxis in solid organ transplant recipients for the prevention of cytomegalovirus relapse: A systematic review and meta‐analysis
Secondary anti‐viral prophylaxis in solid organ transplant recipients for the prevention of cytomegalovirus relapse: A systematic review and meta‐analysis Open
Background Cytomegalovirus (CMV) is a significant cause of morbidity and mortality in solid organ transplant recipients (SOTRs). Secondary prophylaxis (SP) is not routinely recommended by guidelines on the management of CMV in SOTR but may…
View article: Wide variability of the definitions used for native vertebral osteomyelitis: walking the path for a unified diagnostic framework with a meta-epidemiological approach
Wide variability of the definitions used for native vertebral osteomyelitis: walking the path for a unified diagnostic framework with a meta-epidemiological approach Open
View article: Sulfa allergy labels and risk of opportunistic infections after solid organ transplantation
Sulfa allergy labels and risk of opportunistic infections after solid organ transplantation Open
The authors declare no conflict of interest.
View article: Mismanagement of SARS-CoV-2 Infection Pre Hospitalisation during the Omicron Era: Antibiotics and Steroids Instead of Early Antivirals
Mismanagement of SARS-CoV-2 Infection Pre Hospitalisation during the Omicron Era: Antibiotics and Steroids Instead of Early Antivirals Open
The aim of this study was to assess the prevalence of inappropriate treatment among hospitalised patients affected by SARS-CoV-2 infection before hospital admission during the Omicron era. This single-centre, retrospective observational st…
View article: Neurobrucellosis Presenting with Motor Damage or Hearing Loss, and Use of Steroids are Associated with a Higher Risk of Sequelae or Relapse: A Systematic Review of Individual Participant Data
Neurobrucellosis Presenting with Motor Damage or Hearing Loss, and Use of Steroids are Associated with a Higher Risk of Sequelae or Relapse: A Systematic Review of Individual Participant Data Open
View article: Prevalence of extracardiac vascular complications in Abiotrophia spp. and Granulicatella spp. infective endocarditis: Two case reports and a systematic review
Prevalence of extracardiac vascular complications in Abiotrophia spp. and Granulicatella spp. infective endocarditis: Two case reports and a systematic review Open
Objectives: Infective endocarditis (IE) caused by Abiotrophia spp. and Granulicatella spp. share an increased risk of extracardiac vascular complications (EVC). The current work aims to assess the prevalence of EVC in IE due to these micro…
View article: Phage Therapy for Cardiac Implantable Electronic Devices and Vascular Grafts: A Targeted Literature Review
Phage Therapy for Cardiac Implantable Electronic Devices and Vascular Grafts: A Targeted Literature Review Open
Infections of cardiac implantable electronic devices (CIEDs) and vascular grafts are some of the most dreaded complications of these otherwise life-saving devices. Many of these infections are not responsive to conventional treatment, such…
View article: Major Bleeding Events in Hospitalized COVID-19 Patients: A Retrospective Observational Study
Major Bleeding Events in Hospitalized COVID-19 Patients: A Retrospective Observational Study Open
Thromboprophylaxis/anticoagulation treatment is often required in hospitalized COVID-19 patients. We aimed to estimate the prevalence of major bleeding events in hospitalized COVID-19 patients. This was a retrospective observational study …
View article: Traditional Cultures versus Next Generation Sequencing for Suspected Orthopedic Infection: Experience Gained from a Reference Centre
Traditional Cultures versus Next Generation Sequencing for Suspected Orthopedic Infection: Experience Gained from a Reference Centre Open
(Background) The diagnosis and the antimicrobial treatment of orthopedic infection are challenging, especially in cases with culture-negative results. New molecular methods, such as next-generation sequencing (NGS), promise to overcome som…
View article: Trimethoprim-sulfamethoxazole significantly reduces the risk of nocardiosis in solid organ transplant recipients: systematic review and individual patient data meta-analysis
Trimethoprim-sulfamethoxazole significantly reduces the risk of nocardiosis in solid organ transplant recipients: systematic review and individual patient data meta-analysis Open
View article: Rifampin Based Therapy for Patients With <i>Staphylococcus aureus</i> Native Vertebral Osteomyelitis: A Systematic Review and Meta-analysis
Rifampin Based Therapy for Patients With <i>Staphylococcus aureus</i> Native Vertebral Osteomyelitis: A Systematic Review and Meta-analysis Open
Background Native vertebral osteomyelitis (NVO) caused by Staphylococcus aureus is associated with high risk of treatment failure and increased morbidity. The role of rifampin-based therapy for the treatment of this condition is controvers…
View article: <i>Cutibacterium acnes</i> in spine tissue: characteristics and outcomes of non-hardware-associated vertebral osteomyelitis
<i>Cutibacterium acnes</i> in spine tissue: characteristics and outcomes of non-hardware-associated vertebral osteomyelitis Open
Cutibacterium acnes isolation from spine tissue can be challenging because the organism can represent a contaminant. There is a paucity of data regarding the role of C. acnes in non-hardware-associated vertebral osteomyelitis (VO). Herein …
View article: Early switch to oral antibiotic therapy for the treatment of patients with bacterial native vertebral osteomyelitis: a quaternary center experience, systematic review, and meta-analysis
Early switch to oral antibiotic therapy for the treatment of patients with bacterial native vertebral osteomyelitis: a quaternary center experience, systematic review, and meta-analysis Open
Recent data suggest that oral therapy can be effective for bone infections. We aim to assess the efficacy of an early switch to oral therapy (<2 weeks) compared to a non-early switch in bacterial native vertebral osteomyelitis. We conducte…
View article: Differences in Humoral and Cellular Response to COVID-19 Vaccine Against Different Variants over Time in Chronic Lymphocytic Leukemia
Differences in Humoral and Cellular Response to COVID-19 Vaccine Against Different Variants over Time in Chronic Lymphocytic Leukemia Open
Background Patients with chronic lymphocytic leukemia (CLL) are at an increased risk of adverse clinical outcomes following COVID-19 infection, due to impaired humoral and cellular response to infection and vaccination. Most of the data av…
View article: Mortality among Italians and immigrants with COVID-19 hospitalised in Milan, Italy: data from the Luigi Sacco Hospital registry
Mortality among Italians and immigrants with COVID-19 hospitalised in Milan, Italy: data from the Luigi Sacco Hospital registry Open
View article: High Mortality Rate Among Latin American Immigrants With Covid-19 Hospitalised in Milan, Italy: Data From the Luigi Sacco Hospital Registry
High Mortality Rate Among Latin American Immigrants With Covid-19 Hospitalised in Milan, Italy: Data From the Luigi Sacco Hospital Registry Open
Background To assess differences in the probability of COVID-19-related death between native Italians and immigrants hospitalised with COVID-19. Methods This was a retrospective study of prospectively collected data conducted at the ASST F…
View article: Brief Report: Impact of the COVID-19 Pandemic on Virological Suppression in People Living With HIV Attending a Large Italian HIV Clinic
Brief Report: Impact of the COVID-19 Pandemic on Virological Suppression in People Living With HIV Attending a Large Italian HIV Clinic Open
Background: We assessed the impact of the coronavirus disease 2019 (COVID-19) pandemic on HIV suppression rates in people living with HIV (PLWH) attending a large Italian HIV clinic. Setting: The HIV outpatient clinic of the Infectious Dis…
View article: Rapid lateral-flow immunochromatographic tests to assess anti N/S IgG seropositivity after BNT162b2 vaccine: A cross-sectional study
Rapid lateral-flow immunochromatographic tests to assess anti N/S IgG seropositivity after BNT162b2 vaccine: A cross-sectional study Open
View article: Is COVID-19 severity associated with anti-spike antibody duration? Data from the ARCOVID prospective observational study
Is COVID-19 severity associated with anti-spike antibody duration? Data from the ARCOVID prospective observational study Open
View article: Dialoghi tra Università e Cittadinanza: un contributo pedagogico per sostenere le azioni educative in tempo di emergenza pandemica [Dialogues between University and Citizenship: a pedagogical contribution to support educational actions in time of pandemic emergency]
Dialoghi tra Università e Cittadinanza: un contributo pedagogico per sostenere le azioni educative in tempo di emergenza pandemica [Dialogues between University and Citizenship: a pedagogical contribution to support educational actions in time of pandemic emergency] Open
Starting from the widespread distress caused by the Covid-19 pandemic from the first months of 2020, we intend to propose a reflection on the possibility of a pedagogical contribution that can support the knowledge and the practices of edu…
View article: Preliminary observations on IGRA testing for TB infection in patients with severe COVID-19 eligible for immunosuppressive therapy
Preliminary observations on IGRA testing for TB infection in patients with severe COVID-19 eligible for immunosuppressive therapy Open
View article: Short‐term inhibition of SARS‐CoV‐2 by hydrogen peroxide in persistent nasopharyngeal carriers
Short‐term inhibition of SARS‐CoV‐2 by hydrogen peroxide in persistent nasopharyngeal carriers Open
Asymptomatic and convalescent coronavirus disease 2019 (COVID‐19) subjects may carry severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) for months in their upper respiratory ways. Desiring to permanently clean the mucosal surface…