Matteo Perino
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View article: AlphaGenome: advancing regulatory variant effect prediction with a unified DNA sequence model
AlphaGenome: advancing regulatory variant effect prediction with a unified DNA sequence model Open
Deep learning models that predict functional genomic measurements from DNA sequence are powerful tools for deciphering the genetic regulatory code. Existing methods trade off between input sequence length and prediction resolution, thereby…
View article: Loss of PRC2 subunits primes lineage choice during exit of pluripotency
Loss of PRC2 subunits primes lineage choice during exit of pluripotency Open
Polycomb Repressive Complex 2 (PRC2) is crucial for the coordinated expression of genes during early embryonic development, catalyzing histone H3 lysine 27 trimethylation. There are two distinct PRC2 complexes, PRC2.1 and PRC2.2, which con…
View article: Two distinct functional axes of positive feedback-enforced PRC2 recruitment in mouse embryonic stem cells
Two distinct functional axes of positive feedback-enforced PRC2 recruitment in mouse embryonic stem cells Open
Polycomb Repressive Complex 2 (PRC2) plays an essential role in development by catalysing trimethylation of histone H3 lysine 27 (H3K27me3), resulting in gene repression. PRC2 consists of two sub-complexes, PRC2.1 and PRC2.2, in which the …
View article: Mass Spectrometry-Based Absolute Quantification of Single<i>Xenopus</i>Embryo Proteomes
Mass Spectrometry-Based Absolute Quantification of Single<i>Xenopus</i>Embryo Proteomes Open
Early Xenopus development is characterized by a poor correlation between global mRNA and protein abundances due to maternal mRNA and protein loading. Therefore, proteome profiling is necessary to study gene expression dynamics during early…