Matteo Sestili
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View article: Toward the Optimal Choice of Gelled Vehicles for Oral Drug Administration in Dysphagic Patients
Toward the Optimal Choice of Gelled Vehicles for Oral Drug Administration in Dysphagic Patients Open
Background/Objectives: Thickened waters are commonly used for dysphagic patients to ensure hydration, facilitate safer swallowing, and administer oral therapies, yet their impact on drug dissolution remains unclear. This study aims to inve…
View article: Enteral Delivery of Pravastatin Sodium Tablets: Effect of Compounding into a Liquid Form and Co-Administration of Enteral Nutrition
Enteral Delivery of Pravastatin Sodium Tablets: Effect of Compounding into a Liquid Form and Co-Administration of Enteral Nutrition Open
Background: Compounding solid oral dosage forms into liquid preparations is a common practice for administering drug therapy to patients with swallowing difficulties. This is particularly relevant for those on enteral nutrition, where fact…
View article: Tablet Splitting in Elderly Patients with Dementia: The Case of Quetiapine
Tablet Splitting in Elderly Patients with Dementia: The Case of Quetiapine Open
Quetiapine is an atypical antipsychotic approved for treating schizophrenia, bipolar depression, and mania but is frequently used in an off-label manner to control the behavioral and psychological symptoms of dementia in elderly patients w…
View article: Potentially Inappropriate Prescribing of Oral Solid Medications in Elderly Dysphagic Patients
Potentially Inappropriate Prescribing of Oral Solid Medications in Elderly Dysphagic Patients Open
Pharmaceutical formulations suitable for dysphagic patients are not always commercially available, motivating caregivers to crush tablets or open capsules to facilitate swallowing. Since this action may modify the characteristics of the me…
View article: Potassium canrenoate compounding for administration via enteral feeding tubes: a physical and microbiological stability study
Potassium canrenoate compounding for administration via enteral feeding tubes: a physical and microbiological stability study Open
It is possible to compound the original tablets into a liquid formulation suitable for administration via a feeding tube.
View article: Oral drug therapy in elderly with dysphagia: between a rock and a hard place!
Oral drug therapy in elderly with dysphagia: between a rock and a hard place! Open
Demographic indicators forecast that by 2050, the elderly will account for about one-third of the global population. Geriatric patients require a large number of medicines, and in most cases, these products are administered as solid oral s…
View article: Chemical and microbiological stability studies of an aqueous solution of pravastatin sodium salt for drug therapy of the dysphagic patients
Chemical and microbiological stability studies of an aqueous solution of pravastatin sodium salt for drug therapy of the dysphagic patients Open
This study demonstrated the possibility to reformulate pravastatin tablets as liquid pharmaceutical formulation for enteral administration with the aim of improving drug therapy in dysphagic patients.
View article: PP-023 Gravimetric and spectrophotometric quantification of pravastatin sodium salt extemporaneous solutions administered through feeding tube: Effect of preparation methods
PP-023 Gravimetric and spectrophotometric quantification of pravastatin sodium salt extemporaneous solutions administered through feeding tube: Effect of preparation methods Open
Background: Most drugs are available only as solid oral dosage forms. Patients with swallowing difficulties supplied by enteral nutrition (EN) are not able to consume these pharmaceutical forms. Therefore, to improve the management of thei…