Explanipedia

Rare Tumors of Oral Cavity: A Case Report and Literature Review on Secretory Carcinoma of Minor Salivary Glands Open

Emilio Salerno, Silvio Abati, Gianluigi Arrigoni, Daniela Finocchiaro, Giorgio Gastaldi , et al. · 2025

Objectives The primary objective of this study is to report and analyze two rare cases of secretory carcinoma (SC) of the minor salivary glands, focusing on their diagnostic and therapeutic work‐up. The study aims to enhance scientific kno…

Dupilumab: a delayed response in asthmatic and atopic patients treated for chronic rhinosinusitis with nasal polyps Open

Umberto Tanzini, Andrea Rampi, Alessandro Vinciguerra, Giulia Danè, Mona‐Rita Yacoub , et al. · 2024

An adjoint-based approach for the surgical correction of nasal septal deviations Open

Marcello Macellari, Andrea Schillaci, Umberto Tanzini, Matteo Trimarchi, Maurizio Quadrio · 2024

Deviations of the septal wall are widespread anatomic anomalies of the human nose; they vary significantly in shape and location, and often cause the obstruction of the nasal airways. When severe, septal deviations need to be surgically co…

An adjoint-based approach for the surgical correction of nasal septal deviations Open

Marcello Macellari, Andrea Schillaci, Umberto Tanzini, Matteo Trimarchi, Maurizio Quadrio · 2024

Multidimensional Impact of Dupilumab on Chronic Rhinosinusitis with Nasal Polyps: A Complete Health Technology Assessment of Clinical, Economic, and Non-Clinical Domains Open

Ignazio La Mantia, Giancarlo Ottaviano, Martina Ragusa, Matteo Trimarchi, Emanuela Foglia , et al. · 2024

Chronic RhinoSinusitis with Nasal Polyps (CRSwNP) represents a condition mainly caused by the type 2 inflammation presence and marked by the existence of polyps within the nasal and paranasal sinuses. The standard of care includes intranas…

Oncocytic papillary cystadenoma of the larynx: a case report Open

Alberto Caranti, Roberto Spasiano, Renato Piantanida, Salvatore Catalano, Ruggero Campisi , et al. · 2024

Background Cystadenoma of the salivary glands is a rare benign clinical condition affecting both major and minor salivary glands equally. It constitutes approximately 2% of total neoplasms and 4.2–4.7% of benign formations in minor salivar…

Chronic Rhinosinusitis with Nasal Polyps: A Survey on Routine Management and Evaluation of Disease Control in Practice Open

Eugenio De Corso, Giancarlo Ottaviano, Carlotta Pipolo, Elena Cantone, Davide Mattavelli , et al. · 2023

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a disease with a significant impact on quality of life. The overall goal of CRSwNP management, as with other chronic conditions, is to achieve “disease control”, and for that reason, a d…

Practical recommendations for managing severe chronic rhinosinusitis with nasal polyps in the era of biologics Open

Eugenio De Corso, Carlotta Pipolo, Elena Cantone, Giancarlo Ottaviano, Stefania Gallo , et al. · 2023

Clinical practice in rhinology outpatient clinics has changed profoundly in the era of biologics. Our practical recommendations for clinicians working in rhinology centres are expected to help standardise practice and improve care.

Dupilumab in the treatment of severe uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP): A multicentric observational Phase IV real‐life study (DUPIREAL) Open

Eugenio De Corso, Ernesto Pasquini, Matteo Trimarchi, Ignazio La Mantia, Fabio Pagella , et al. · 2023

Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is associated with significant morbidity and reduced health‐related quality of life. Findings from clinical trials have demonstrated the effectiveness of dupilumab in CRSwNP, alt…

Activation of Mast Cells by Neuropeptides: The Role of Pro-Inflammatory and Anti-Inflammatory Cytokines Open

D Lauritano, F Mastrangelo, Cristian D’Ovidio, Gianpaolo Ronconi, A. Caraffa , et al. · 2023

Mast cells (MCs) are tissue cells that are derived from bone marrow stem cells that contribute to allergic reactions, inflammatory diseases, innate and adaptive immunity, autoimmunity, and mental disorders. MCs located near the meninges co…

Use of a Fiberoptic-Laser Approach During Endoscopic Sinus Surgery: A Cadaver Feasibility Study Open

Matteo Trimarchi, Alessandro Vinciguerra, Andrea Rampi, Gianluigi Arrigoni, Claudio Doglioni , et al. · 2023

Activation of Mast Cells by Neuropeptides: The Role of Pro-inflammatory and Anti-Inflammatory Cytokines Open

D Lauritano, F Mastrangelo, Cristian D’Ovidio, Gianpaolo Ronconi, A. Caraffa , et al. · 2023

Mass cells (MCs) are tissue cells that are derived from bone marrow stem cells that contribute to allergic reactions, inflammatory diseases, innate and adaptive immunity, autoimmunity, and mental disorders. MCs located near the meninges co…

A prospective study on the efficacy of dupilumab in chronic rhinosinusitis with type 2 inflammation Open

Matteo Trimarchi, Alessandro Vinciguerra, Andrea Rampi, Umberto Tanzini, Alessandro Nonis , et al. · 2022

Dupilumab was confirmed to be an effective and safe treatment for CRSwNP, as previously seen in registrational studies.

Mast Cell Cytokines in Acute and Chronic Gingival Tissue Inflammation: Role of IL-33 and IL-37 Open

Matteo Trimarchi, D Lauritano, Gianpaolo Ronconi, A. Caraffa, Carla Enrica Gallenga , et al. · 2022

Much evidence suggests autoimmunity in the etiopathogenesis of periodontal disease. In fact, in periodontitis, there is antibody production against collagen, DNA, and IgG, as well as increased IgA expression, T cell dysfunction, high expre…

Endoscopic and external dacryocystorhinostomy: A therapeutic proposal for distal acquired lacrimal obstructions Open

Alessandro Vinciguerra, Antonio Giordano Resti, Andrea Rampi, Mario Bussi, Francesco Bandello , et al. · 2022

Endoscopic (END-DCR) and external dacryocystorhinostomies (EXT-DCR) are nowadays considered the gold standard techniques for non-oncologic distal acquired lacrimal disorders (DALO). However, no unanimous consensus has been achieved on whic…

Determination of costs for the CSRwNP pathway. A time-driven activity-based costing experiment Open

Matteo Trimarchi, Emanuela Foglia, Fabrizio Schettini, Daniele Bellavia, Alessandro Vinciguerra , et al. · 2022

The results demonstrate the strategic relevance of analytical cost definitions of the clinical pathway for CRSwNP, which can help to support decision makers in the review of internal procedures and in the definition of proper reimbursement…

The impact of near-infrared autofluorescence on postoperative hypoparathyroidism during total thyroidectomy: a case-control study Open

Diego Barbieri, Pietro Indelicato, Alessandro Vinciguerra, Emilio Salerno, Rosa Alessia Battista , et al. · 2022

Purpose : Near-infrared autofluorescence is a new technology in thyroid surgery to better localize and preserve parathyroid glands. The purpose of this study is to assess if the adoption of NIR-AF can improve in short-, medium-, and long-t…

Survey on Use of Local and Systemic Corticosteroids in the Management of Chronic Rhinosinusitis with Nasal Polyps: Identification of Unmet Clinical Needs Open

Eugenio De Corso, Carlotta Pipolo, Elena Cantone, Giancarlo Ottaviano, Stefania Gallo , et al. · 2022

Background: Local and systemic corticosteroids have long been the workhorse in management of chronic rhinosinusitis with nasal polyps (CRSwNP), although there is no universally accepted modality of prescription. We carried out a survey in …

Follicular helper T cell signature of replicative exhaustion, apoptosis, and senescence in common variable immunodeficiency Open

Giulia Milardi, Biagio Di Lorenzo, Jolanda Gerosa, Federica Barzaghi, Gigliola Di Matteo , et al. · 2022

Common variable immunodeficiency (CVID) is the most frequent primary antibody deficiency whereby follicular helper T (Tfh) cells fail to establish productive responses with B cells in germinal centers. Here, we analyzed the frequency, phen…

Early diagnosis of oral squamous cell carcinoma may ensure better prognosis: A case series Open

Chiara Bramati, Silvio Abati, Stefano Bondi, Alessandra Lissoni, Gianluigi Arrigoni , et al. · 2021

Oral squamous cell carcinoma is an extremely malignant tumour: in order to reduce mortality and morbidity, early diagnosis and treatment is the clinician's best weapon.

Early diagnosis of oral squamous cell carcinoma may ensure better prognosis: a case series Open

Chiara Bramati, Silvio Abati, Stefano Bondi, Alessandra Lissoni, Gianluigi Arrigoni , et al. · 2021

Oral squamous cell carcinoma (OSCC) is a malignancy with high mortality and morbidity. Early diagnosis and treatment of OSCC and other potentially malignant lesions of the oral mucosa is the clinician’s best weapon to improve prognosis, si…

Gene Expression Analysis in Patients with Cocaine-Induced Midline Destructive Lesions Open

Matteo Trimarchi, Giacomo Bertazzoni, Alessandro Vinciguerra, Celia Pardini, Fabio Simeoni , et al. · 2021

Background and Objectives: Cocaine users may present with positive antineutrophil cytoplasmic antibodies (ANCA) and severe midline destructive lesions (CIMDL) which are histologically characterized by massive apoptosis. However, histopatho…

Long-term results of a balloon-assisted endoscopic approach in failed dacryocystorhinostomies Open

Alessandro Vinciguerra, Pietro Indelicato, Antonio Giordano Resti, Mario Bussi, Matteo Trimarchi · 2021

Follicular helper T cell signature of replicative exhaustion, apoptosis and senescence in common variable immunodeficiency Open

Giulia Milardi, Biagio Di Lorenzo, Jolanda Gerosa, Federica Barzaghi, Gigliola Di Matteo , et al. · 2021

Background Common variable immunodeficiency (CVID) is the most frequent primary antibody deficiency. A significant number of CVID patients are affected by various manifestations of immune dysregulation such as autoimmunity. Follicular T ce…

Multidisciplinary approach to lacrimal system diseases Open

Matteo Trimarchi, Alessandro Vinciguerra, Antonio Giordano Resti, Leone Giordano, Mario Bussi · 2021

Pathologies of the lacrimal drainage system range from benign to malignant lesions. However, independently of the etiological origin, the most common presenting symptom is represented by epiphora due to the dysfunction of the lacrimal syst…

Clinical efficacy of dupilumab in the treatment of severe chronic rhinosinusitis: The first case outside of a clinical trial Open

Matteo Trimarchi, Pietro Indelicato, Alessandro Vinciguerra, Mario Bussi · 2021

Treatment options for severe CRSwNP are limited. Dupilumab is a safe, well‐tolerated, and effective alternative in patients with poor control of symptoms, corticosteroid‐dependent disease, and high rates of recurrence of nasal polyps after…

Vinegar and its active component acetic acid inhibit SARS-CoV-2 infection in vitro and ex vivo Open

Isabel Pagani, Silvia Ghezzi, Massimo Clementi, Guido Poli, Mario Bussi , et al. · 2021

Interferon; ACE2: Angiotensin converting enzyme 2. Vero cells were seeded at 2.5×10 5 cell/well in 24-well plates in Eagle's minimum essential medium (EMEM) supplemented with 10% fetal calf serum (complete medium).Twenty-four h later, 50 p…

Oral Cancer and Precancer: A Narrative Review on the Relevance of Early Diagnosis Open

Silvio Abati, Chiara Bramati, Stefano Bondi, Alessandra Lissoni, Matteo Trimarchi · 2020

Oral cancer (OC) is an uncommon malignancy in Western countries, being one of the most common cancers in some high-risk areas of the world. It is a largely preventable cancer, since most of the different risk factors identified, such as to…

Clinical efficacy of dupilumab in the treatment of severe chronic rhinosinusitis Open

Matteo Trimarchi, Pietro Indelicato, Alessandro Vinciguerra, Mario Bussi · 2020

Chronic rhinosinusitis with nasal polyps is a type 2-mediated inflammatory disease associated with significant burden due to symptoms and high recurrence rate after surgery. Dupilumab, a monoclonal antibody against the interleukin-4 recept…

Vinegar and Its Active Component Acetic Acid Inhibit SARS-CoV-2 InfectionIn VitroandEx Vivo Open

Isabel Pagani, Silvia Ghezzi, Massimo Clementi, Guido Poli, Mario Bussi , et al. · 2020

Effective and economical measures are needed to either prevent or inhibit the replication of SARS-CoV-2, the causative agent of COVID-19, in the upper respiratory tract. As fumigation of vinegar at low concentration (0.34%) ameliorated the…

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