Mattheus Xing Rong Foo
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View article: Genetic and pharmacological modulation of lamin A farnesylation determines its function and turnover
Genetic and pharmacological modulation of lamin A farnesylation determines its function and turnover Open
Hutchinson–Gilford Progeria syndrome (HGPS) is a severe premature ageing disorder caused by a 50 amino acid truncated (Δ50AA) and permanently farnesylated lamin A (LA) mutant called progerin. On a cellular level, progerin expression leads …
View article: Molecular functions of the nuclear lamina in premature cell ageing
Molecular functions of the nuclear lamina in premature cell ageing Open
Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature ageing syndrome that manifests as early as 1 year of age. Patients exhibit severe phenotypes such as bone defects, cardiovascular complications, and a mean lifespan of 14 years. HG…
View article: Heterochromatin loss as a determinant of progerin‐induced DNA damage in Hutchinson–Gilford Progeria
Heterochromatin loss as a determinant of progerin‐induced DNA damage in Hutchinson–Gilford Progeria Open
Hutchinson–Gilford progeria is a premature aging syndrome caused by a truncated form of lamin A called progerin. Progerin expression results in a variety of cellular defects including heterochromatin loss, DNA damage, impaired proliferatio…
View article: Premature aging syndromes: From patients to mechanism
Premature aging syndromes: From patients to mechanism Open