Matthew A. Hunt
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View article: An Integrated Dataset of Metastatic Breast Cancer to the Brain with Imaging, Radiomics, and Tumor Genetics
An Integrated Dataset of Metastatic Breast Cancer to the Brain with Imaging, Radiomics, and Tumor Genetics Open
View article: RBIO-19. Radiation-Mediated MDSC Immunodynamics in Recurrent High-Grade Glioma
RBIO-19. Radiation-Mediated MDSC Immunodynamics in Recurrent High-Grade Glioma Open
Myeloid-derived suppressor cells (MDSCs) contribute to an immunosuppressive tumor microenvironment that facilitates cancer progression, particularly in patients with high-grade gliomas. We previously reported that increased MDSCs during ch…
View article: Low-loss superconducting resonators fabricated from tantalum films grown at room temperature
Low-loss superconducting resonators fabricated from tantalum films grown at room temperature Open
The use of α -tantalum in superconducting circuits has enabled a considerable improvement in the coherence time of transmon qubits. The standard approach to grow α -tantalum thin films on silicon involves heating the substrate, which takes…
View article: Hardware-efficient quantum error correction via concatenated bosonic qubits
Hardware-efficient quantum error correction via concatenated bosonic qubits Open
View article: Low-Loss Superconducting Resonators Fabricated from Tantalum Films Grown at Room Temperature
Low-Loss Superconducting Resonators Fabricated from Tantalum Films Grown at Room Temperature Open
The use of $α$-tantalum in superconducting circuits has enabled a considerable improvement of the coherence time of transmon qubits. The standard approach to grow $α$-tantalum thin films on silicon involves heating the substrate, which tak…
View article: Hardware-efficient quantum error correction via concatenated bosonic qubits
Hardware-efficient quantum error correction via concatenated bosonic qubits Open
In order to solve problems of practical importance, quantum computers will likely need to incorporate quantum error correction, where a logical qubit is redundantly encoded in many noisy physical qubits. The large physical-qubit overhead t…
View article: MMOD-12 PATHOLOGIC INCIDENCE OF TUMOR POSITIVITY VS ONLY NECROSIS AFTER PRIOR RADIATION IN PATIENTS UNDERGOING SURGICAL EXCISION FOR PRESUMED BRAIN METASTASIS RECURRENCE: INSIGHT FROM A PROSPECTIVE MULTICENTER REGISTRY
MMOD-12 PATHOLOGIC INCIDENCE OF TUMOR POSITIVITY VS ONLY NECROSIS AFTER PRIOR RADIATION IN PATIENTS UNDERGOING SURGICAL EXCISION FOR PRESUMED BRAIN METASTASIS RECURRENCE: INSIGHT FROM A PROSPECTIVE MULTICENTER REGISTRY Open
PURPOSE/OBJECTIVE(S) Determining true recurrence versus necrosis alone after previous radiation therapy (RT) for brain metastasis based on imaging alone is difficult. Proper diagnosis is essential, as further radiation is contraindicated i…
View article: Demonstrating a Long-Coherence Dual-Rail Erasure Qubit Using Tunable Transmons
Demonstrating a Long-Coherence Dual-Rail Erasure Qubit Using Tunable Transmons Open
Quantum error correction with erasure qubits promises significant advantages over standard error correction due to favorable thresholds for erasure errors. To realize this advantage in practice requires a qubit for which nearly all errors …
View article: Data from Oxygen Is a Master Regulator of the Immunogenicity of Primary Human Glioma Cells
Data from Oxygen Is a Master Regulator of the Immunogenicity of Primary Human Glioma Cells Open
With recent approval of the first dendritic cell (DC) vaccine for patient use, many other DC vaccine approaches are now being tested in clinical trials. Many of these DC vaccines employ tumor cell lysates (TL) generated from cells cultured…
View article: Supplementary Table 2 from Vaccination for Invasive Canine Meningioma Induces <i>In Situ</i> Production of Antibodies Capable of Antibody-Dependent Cell-Mediated Cytotoxicity
Supplementary Table 2 from Vaccination for Invasive Canine Meningioma Induces <i>In Situ</i> Production of Antibodies Capable of Antibody-Dependent Cell-Mediated Cytotoxicity Open
PDF file - 55K, Table describing survival times and causes of death for surgery historical control dogs.
View article: Supplementary Table 2 from Vaccination for Invasive Canine Meningioma Induces <i>In Situ</i> Production of Antibodies Capable of Antibody-Dependent Cell-Mediated Cytotoxicity
Supplementary Table 2 from Vaccination for Invasive Canine Meningioma Induces <i>In Situ</i> Production of Antibodies Capable of Antibody-Dependent Cell-Mediated Cytotoxicity Open
PDF file - 55K, Table describing survival times and causes of death for surgery historical control dogs.
View article: Data from Oxygen Is a Master Regulator of the Immunogenicity of Primary Human Glioma Cells
Data from Oxygen Is a Master Regulator of the Immunogenicity of Primary Human Glioma Cells Open
With recent approval of the first dendritic cell (DC) vaccine for patient use, many other DC vaccine approaches are now being tested in clinical trials. Many of these DC vaccines employ tumor cell lysates (TL) generated from cells cultured…
View article: Supplementary Tables 1-3, Figures 1-6 and Methods from Oxygen Is a Master Regulator of the Immunogenicity of Primary Human Glioma Cells
Supplementary Tables 1-3, Figures 1-6 and Methods from Oxygen Is a Master Regulator of the Immunogenicity of Primary Human Glioma Cells Open
Supplementary Tables 1-3, Figures 1-6 and Methods from Oxygen Is a Master Regulator of the Immunogenicity of Primary Human Glioma Cells
View article: Supplementary Methods from Vaccination for Invasive Canine Meningioma Induces <i>In Situ</i> Production of Antibodies Capable of Antibody-Dependent Cell-Mediated Cytotoxicity
Supplementary Methods from Vaccination for Invasive Canine Meningioma Induces <i>In Situ</i> Production of Antibodies Capable of Antibody-Dependent Cell-Mediated Cytotoxicity Open
PDF file - 75K, Contains descriptions of two methods used to acquire clinical histology and T cell response data.
View article: Predicting Glioblastoma Cellular Motility from In Vivo MRI with a Radiomics Based Regression Model
Predicting Glioblastoma Cellular Motility from In Vivo MRI with a Radiomics Based Regression Model Open
Characterizing the motile properties of glioblastoma tumor cells could provide a useful way to predict the spread of tumors and to tailor the therapeutic approach. Radiomics has emerged as a diagnostic tool in the classification of tumor g…
View article: Odontoid Fracture as Proximal Junctional Failure in Patients With Multilevel Spine Fusions
Odontoid Fracture as Proximal Junctional Failure in Patients With Multilevel Spine Fusions Open
Study Design: Retrospective study. Objective: Proximal junctional failure (PJF) commonly occurs as a recognized potential outcome of fusion surgery. Here we describe a unique series of patients with multilevel spine fusion including the ce…
View article: A radiomics-based model for predicting local control of resected brain metastases receiving adjuvant SRS
A radiomics-based model for predicting local control of resected brain metastases receiving adjuvant SRS Open
View article: Minor Changes with Large Implications: Modeling Amino Acid Mutations in SARS‐CoV Monoclonal Antibodies (80R and 362) Towards the Design of More Universal Antibodies
Minor Changes with Large Implications: Modeling Amino Acid Mutations in SARS‐CoV Monoclonal Antibodies (80R and 362) Towards the Design of More Universal Antibodies Open
The SARS‐CoV‐2 virus is responsible for the COVID‐19 pandemic which continues to impact nearly every person on Earth, having caused over 1.8 million deaths. Two anti‐SARS‐CoV monoclonal antibodies (MAbs) 80R and 362 are known to bind to ep…
View article: How to observe and quantify quantum-discord states via correlations
How to observe and quantify quantum-discord states via correlations Open
Quantum correlations between parts of a composite system most clearly reveal\nthemselves through entanglement. Designing, maintaining, and controlling\nentangled systems is very demanding, which raises the stakes for understanding\nthe eff…
View article: Tumor Cavity Shape Characteristics Do Not Predict Local Control in Patients with Resected Brain Metastases Receiving Adjuvant SRS
Tumor Cavity Shape Characteristics Do Not Predict Local Control in Patients with Resected Brain Metastases Receiving Adjuvant SRS Open
View article: Treatment Combining CD200 Immune Checkpoint Inhibitor and Tumor-Lysate Vaccination after Surgery for Pet Dogs with High-Grade Glioma
Treatment Combining CD200 Immune Checkpoint Inhibitor and Tumor-Lysate Vaccination after Surgery for Pet Dogs with High-Grade Glioma Open
Recent advances in immunotherapy have included inhibition of immune checkpoint proteins in the tumor microenvironment and tumor lysate-based vaccination strategies. We combined these approaches in pet dogs with high-grade glioma. Administr…
View article: Naturally Occurring Canine Glioma as a Model for Novel Therapeutics
Naturally Occurring Canine Glioma as a Model for Novel Therapeutics Open
Background: Current animal models of glioma are limited to small animal models, which are less predictive of treatment of human disease. Canines often develop gliomas de novo, but the natural history of the disease is not wel…
View article: A Comparison of the Existing Wellness Programs in Neurosurgery and Institution Champion's Perspectives
A Comparison of the Existing Wellness Programs in Neurosurgery and Institution Champion's Perspectives Open
Once the accepted norm during Harvey Cushing's time, the mantra of work to the exclusion of family and lifestyle is now recognized as deleterious to overall well-being. A number of neurosurgical residency training programs have implemented…
View article: Near complete response to Pembrolizumab in microsatellite-stable metastatic sebaceous carcinoma
Near complete response to Pembrolizumab in microsatellite-stable metastatic sebaceous carcinoma Open
This is the first report describing objective clinical and radiographic responses following immunotherapy for widely metastatic sebaceous carcinoma. The dramatic therapeutic response to pembrolizumab was associated with peripheral blood ci…
View article: Effect of Gamma Knife Radiosurgery and Programmed Cell Death 1 Receptor Antagonists on Metastatic Melanoma
Effect of Gamma Knife Radiosurgery and Programmed Cell Death 1 Receptor Antagonists on Metastatic Melanoma Open
Learning objectives To evaluate radiation-induced changes in patients with brain metastasis secondary to malignant melanoma who received treatment with Gamma Knife radiosurgery (GKRS) and programmed cell death 1 (PD-1) receptor antagonists…
View article: TMOD-25. PEPTIDES OF IMMUNE CHECKPOINT PROTEIN, CD200 (OX2), ENHANCES THE RESPONSE TO VACCINE-BASED IMMUNOTHERAPY IN DOGS WITH HIGH-GRADE GLIOMA
TMOD-25. PEPTIDES OF IMMUNE CHECKPOINT PROTEIN, CD200 (OX2), ENHANCES THE RESPONSE TO VACCINE-BASED IMMUNOTHERAPY IN DOGS WITH HIGH-GRADE GLIOMA Open
Glioma is the most common primary intra-axial brain tumor in dogs and people and carries a poor prognosis. We have been testing novel glioma therapies in pet dogs with glioma. The median survival of dogs treated with surgery and autologous…
View article: Influence of Molecular Subtype on Tumor Response for Breast Cancer Brain Metastases Treated With Stereotactic Radiosurgery
Influence of Molecular Subtype on Tumor Response for Breast Cancer Brain Metastases Treated With Stereotactic Radiosurgery Open
View article: Thoracic spinal cord impingement by an arachnoid web at the level of a hemivertebra: case report
Thoracic spinal cord impingement by an arachnoid web at the level of a hemivertebra: case report Open
Congenital scoliosis due to a hemivertebra requires surgical stabilization prior to skeletal maturity if rapidly progressive curve growth occurs. Here the authors present the unique case of a man who, at the age of 12 years, had undergone …
View article: Intrathoracic meningocele associated with neurofibromatosis Type 1 and a novel technique for surgical repair: case report
Intrathoracic meningocele associated with neurofibromatosis Type 1 and a novel technique for surgical repair: case report Open
Neurofibromatosis Type 1 (NF1) is a neurocutaneous disorder that can have associated spinal abnormalities related to both bone and dural dysplasia. Thoracic meningoceles are one spine anomaly associated with NF1, although they are a fairly…
View article: Commentary: An Introduction to Leadership Self-Assessment at the Society of Neurological Surgeons Post-Graduate Year 1 Boot Camp: Observations and Commentary
Commentary: An Introduction to Leadership Self-Assessment at the Society of Neurological Surgeons Post-Graduate Year 1 Boot Camp: Observations and Commentary Open
Recent trends in graduate medical education have emphasized the mastery of nontechnical skills, especially leadership, for neurosurgical trainees. Accordingly, we introduced leadership development and self-awareness training to interns att…