Matthew A. Pappas
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View article: Patient blood management data and metrics—two key components
Patient blood management data and metrics—two key components Open
View article: Failure of the Femoral Neck System in a Young Patient: A Case Report
Failure of the Femoral Neck System in a Young Patient: A Case Report Open
Introduction: Femoral neck fractures in young adults are rare but carry a high risk of complications, including non-union and implant failure. The femoral neck system™ (FNS) is a newer fixation device designed to enhance mechanical stabili…
View article: Impact of empiric antibiotics on risk of <i>Clostridioides difficile</i>—a causal inference observational analysis
Impact of empiric antibiotics on risk of <i>Clostridioides difficile</i>—a causal inference observational analysis Open
Background: Clostridioides difficile infection (CDI) is a common and often nosocomial infection associated with increased mortality and morbidity. Antibiotic use is the most important modifiable risk factor, but many patients require empir…
View article: What Constitutes High Risk for Venous Thromboembolism? Comparing Approaches to Determining an Appropriate Threshold
What Constitutes High Risk for Venous Thromboembolism? Comparing Approaches to Determining an Appropriate Threshold Open
Background Guidelines recommend pharmacological venous thromboembolism (VTE) prophylaxis only for high-risk patients, but the probability of VTE considered “high-risk” is not specified. Our objective was to define an appropriate probabilit…
View article: Development and internal validation of the Cleveland Clinic Bleeding Model to predict major bleeding risk at admission in medical inpatients
Development and internal validation of the Cleveland Clinic Bleeding Model to predict major bleeding risk at admission in medical inpatients Open
Using a large population of medical inpatients with verified major bleeding events, we developed and internally validated a RAM for major bleeding whose performance surpassed the IMPROVE model.
View article: Clinical Characteristics and Risk Factors for Clostridioides difficile Infection in the Hematopoietic Cell Transplantation Population
Clinical Characteristics and Risk Factors for Clostridioides difficile Infection in the Hematopoietic Cell Transplantation Population Open
View article: Clinicians' interpretation of thresholds in hospital antibiograms for gram‐negative rod infections: A survey and contingent valuation study of hospitalists
Clinicians' interpretation of thresholds in hospital antibiograms for gram‐negative rod infections: A survey and contingent valuation study of hospitalists Open
Clinical guidelines suggest that hospital antibiograms are a key component when deciding empiric therapy, but little is known about how often clinicians use antibiograms and how they influence clinicians' empiric therapy decisions. We surv…
View article: Diagnostic and prognostic value of cardiac stress testing before major noncardiac surgery—A cohort study
Diagnostic and prognostic value of cardiac stress testing before major noncardiac surgery—A cohort study Open
View article: Consequences of preoperative cardiac stress testing—A cohort study
Consequences of preoperative cardiac stress testing—A cohort study Open
View article: A Novel Risk Assessment Model Predicts Major Bleeding Risk at Admission in Medical Inpatients
A Novel Risk Assessment Model Predicts Major Bleeding Risk at Admission in Medical Inpatients Open
Background Venous thromboembolism (VTE) is the leading cause of preventable hospital death in the US. Guidelines from the American College of Chest Physicians and American Society for Hematology recommend providing pharmacological VTE prop…
View article: State of research in adult Hospital Medicine: Updated results of a national survey and longitudinal analysis of national data
State of research in adult Hospital Medicine: Updated results of a national survey and longitudinal analysis of national data Open
We sought to understand the current state of research in adult Hospital Medicine by repeating a 2018 survey of leaders in Hospital Medicine with changes to improve the response rate of surveyed programs. We also analyzed the public sources…
View article: Relationship Between Oral Temperature and Bacteremia in Hospitalized Patients
Relationship Between Oral Temperature and Bacteremia in Hospitalized Patients Open
View article: Estimating the costs of physician turnover in hospital medicine
Estimating the costs of physician turnover in hospital medicine Open
Background and Objective Costs of physician turnover are lacking for specialties organized around a site of care. We sought to estimate the cost of physician turnover in adult hospital medicine (HM). Design, Setting, Participants A retrosp…
View article: Volume and Outcomes of Joint Arthroplasty
Volume and Outcomes of Joint Arthroplasty Open
View article: Prescribing of anticoagulation for atrial fibrillation in primary care
Prescribing of anticoagulation for atrial fibrillation in primary care Open
View article: Variation in preoperative stress testing by patient, physician and surgical type: a cohort study
Variation in preoperative stress testing by patient, physician and surgical type: a cohort study Open
Objectives To describe variation in and drivers of contemporary preoperative cardiac stress testing. Setting A dedicated preoperative risk assessment and optimisation clinic at a large integrated medical centre from 2008 through 2018. Part…
View article: Oral Temperature of Noninfected Hospitalized Patients
Oral Temperature of Noninfected Hospitalized Patients Open
This study describes oral temperatures in a large sample of nonsurgical inpatients without infections to inform evaluation of fever in the hospital.
View article: COVID-19 coagulopathy and thrombosis: Analysis of hospital protocols in response to the rapidly evolving pandemic
COVID-19 coagulopathy and thrombosis: Analysis of hospital protocols in response to the rapidly evolving pandemic Open
View article: Net clinical benefit of anticoagulation for atrial fibrillation following intracerebral hemorrhage
Net clinical benefit of anticoagulation for atrial fibrillation following intracerebral hemorrhage Open
Following an anticoagulation-associated intracerebral hemorrhage (ICH), whether and when to resume anticoagulation is controversial. Patient-level recurrence risk is difficult to predict with accuracy, but time-based recurrence risk may be…
View article: Cost-Effectiveness of Bridging Anticoagulation
Cost-Effectiveness of Bridging Anticoagulation Open
View article: Cost-Effectiveness of Bridging Anticoagulation Among Patients with Nonvalvular Atrial Fibrillation
Cost-Effectiveness of Bridging Anticoagulation Among Patients with Nonvalvular Atrial Fibrillation Open
View article: Resuming Anticoagulation following Upper Gastrointestinal Bleeding among Patients with Nonvalvular Atrial Fibrillation�A Microsimulation Analysis
Resuming Anticoagulation following Upper Gastrointestinal Bleeding among Patients with Nonvalvular Atrial Fibrillation�A Microsimulation Analysis Open
For patients with NVAF following UGIB, warfarin is optimally restarted approximately six weeks following hemostasis, and apixaban is optimally restarted approximately one month following hemostasis. Modest changes to this timing based on p…
View article: Estimating the Accuracy of Dobutamine Stress Echocardiography and Single‐photon Emission Computed Tomography among Patients Undergoing Noncardiac Surgery
Estimating the Accuracy of Dobutamine Stress Echocardiography and Single‐photon Emission Computed Tomography among Patients Undergoing Noncardiac Surgery Open
When cardiac stress testing is ordered prior to noncardiac surgery, the optimal test modality is unknown. Therefore, we conducted this study to compare the diagnostic accuracy of dobutamine stress echocardiography (DSE) and single‐photon e…
View article: Reducing age bias in decision analyses of anticoagulation for patients with nonvalvular atrial fibrillation – A microsimulation study
Reducing age bias in decision analyses of anticoagulation for patients with nonvalvular atrial fibrillation – A microsimulation study Open
The ratio of QALYs lost to ICH relative to ischemic stroke varies with age and discount rate. We present a set of such ratios here for use in decision analyses that do not incorporate full microsimulation models. Use of weighting ratios th…
View article: A decision model to estimate a risk threshold for venous thromboembolism prophylaxis in hospitalized medical patients
A decision model to estimate a risk threshold for venous thromboembolism prophylaxis in hospitalized medical patients Open
View article: Personalizing Bridging Anticoagulation in Patients with Nonvalvular Atrial Fibrillation—a Microsimulation Analysis
Personalizing Bridging Anticoagulation in Patients with Nonvalvular Atrial Fibrillation—a Microsimulation Analysis Open
View article: Defining Appropriate Use of Proton-Pump Inhibitors Among Medical Inpatients
Defining Appropriate Use of Proton-Pump Inhibitors Among Medical Inpatients Open