Matthew A. Rysavy
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View article: Corrigendum to “Two-year outcomes after early postnatal high-dose fat-soluble enteral vitamin A supplementation in extremely low birth weight infants: follow-up of the NeoVitaA randomized controlled trial”
Corrigendum to “Two-year outcomes after early postnatal high-dose fat-soluble enteral vitamin A supplementation in extremely low birth weight infants: follow-up of the NeoVitaA randomized controlled trial” Open
View article: Comparison of neurodevelopmental outcomes of extremely preterm infants undergoing trans-catheter closure of the patent ductus arteriosus compared to surgical ligation
Comparison of neurodevelopmental outcomes of extremely preterm infants undergoing trans-catheter closure of the patent ductus arteriosus compared to surgical ligation Open
Background There is a paucity of data on neurodevelopmental outcomes in preterm infants who undergo transcatheter patent ductus arteriosus (PDA) closure (TCPC). Objective To evaluate neurodevelopmental impairment (NDI) or death at 2 years …
View article: Two-year outcomes after early postnatal high-dose fat-soluble enteral vitamin A supplementation in extremely low birth weight infants: follow-up of the NeoVitaA randomized controlled trial
Two-year outcomes after early postnatal high-dose fat-soluble enteral vitamin A supplementation in extremely low birth weight infants: follow-up of the NeoVitaA randomized controlled trial Open
View article: Seeing beyond the obvious: pragmatic skin care guidance for infants 22–24 weeks gestational age
Seeing beyond the obvious: pragmatic skin care guidance for infants 22–24 weeks gestational age Open
During the past decade, infants born as early as 22–24 weeks’ gestation have been admitted to neonatal intensive care units in increasing numbers. This has facilitated a need for greater understanding of skin physiology and structure, as w…
View article: Meconium obstruction of prematurity in tiny babies – towards developing an international consensus
Meconium obstruction of prematurity in tiny babies – towards developing an international consensus Open
Intestinal perforation occurring in extremely low gestational age neonates is a devastating complication, associated with high mortality and morbidity. Multiple phenotypes of bowel perforation in premature infants have been described, with…
View article: Evaluating the accuracy of point of care testing compared to standard laboratory testing among inborn infants in the neonatal intensive care unit
Evaluating the accuracy of point of care testing compared to standard laboratory testing among inborn infants in the neonatal intensive care unit Open
Objective Point-of-care (POC) testing offers expedited results with lower blood volume requirements than central laboratory (CL) tests, particularly beneficial for low-birth-weight infants. Methods A retrospective cohort of 118 patients wi…
View article: Evaluating the efficacy and safety of milrinone for prevention of post-patent ductus arteriosus closure syndrome (the MIDAS trial) in extremely preterm infants: a multicentre, double-masked, randomised, placebo-controlled trial
Evaluating the efficacy and safety of milrinone for prevention of post-patent ductus arteriosus closure syndrome (the MIDAS trial) in extremely preterm infants: a multicentre, double-masked, randomised, placebo-controlled trial Open
Introduction Post-ligation cardiac syndrome (PLCS) represents a state of severe post-intervention cardiopulmonary instability, seen in up to 50% of extremely premature infants after surgical closure of the patent ductus arteriosus (PDA); y…
View article: New Anhydramnios after 22 Weeks and Pulmonary Hypoplasia
New Anhydramnios after 22 Weeks and Pulmonary Hypoplasia Open
Introduction: Anhydramnios due to renal failure prior to 22 weeks of gestational age (WGA) is associated with lethal pulmonary hypoplasia but after 22 WGA outcomes are less clear. We evaluated whether these fetuses, with new anhydramnios a…
View article: Generalizability Analyses with a Partially Nested Trial Design: The Necrotizing Enterocolitis Surgery Trial
Generalizability Analyses with a Partially Nested Trial Design: The Necrotizing Enterocolitis Surgery Trial Open
We discuss generalizability analyses under a partially nested trial design, where part of the trial is nested within a cohort of trial-eligible individuals, while the rest of the trial is not nested. This design arises, for example, when o…
View article: Tiny baby math: supralinear implications for management of infants born at less than 24 weeks gestation
Tiny baby math: supralinear implications for management of infants born at less than 24 weeks gestation Open
View article: Short Duration of Antenatal Corticosteroid Exposure and Outcomes in Extremely Preterm Infants
Short Duration of Antenatal Corticosteroid Exposure and Outcomes in Extremely Preterm Infants Open
Importance When preterm delivery is imminent, it remains unclear whether the timing from administration of antenatal betamethasone to birth may reduce mortality and morbidity among extremely preterm infants. Objective To evaluate the assoc…
View article: Comparing methods for risk prediction of multicategory outcomes: dichotomized logistic regression vs. multinomial logit regression
Comparing methods for risk prediction of multicategory outcomes: dichotomized logistic regression vs. multinomial logit regression Open
Estimating multiple logistic regression models of dichotomized outcomes may result in poorly calibrated predictions for an outcome with multiple ordinal categories. Multinomial continuation-ratio logit regression produces better calibrated…
View article: Acetaminophen for Patent Ductus Arteriosus and Risk of Mortality and Pulmonary Morbidity
Acetaminophen for Patent Ductus Arteriosus and Risk of Mortality and Pulmonary Morbidity Open
OBJECTIVE Emerging data indicate that acetaminophen may adversely affect lung health. We examined whether acetaminophen compared with cyclooxygenase (COX) inhibitor alone for patent ductus arteriosus (PDA) is associated with mortality or r…
View article: Randomized controlled trial of enteral vitamin D supplementation (ViDES) in infants <28 weeks gestational age or <1000 g birth weight: study protocol
Randomized controlled trial of enteral vitamin D supplementation (ViDES) in infants <28 weeks gestational age or <1000 g birth weight: study protocol Open
View article: Randomized Controlled Trial of Enteral Vitamin D Supplementation (ViDES) in Infants &lt;28 Weeks Gestational Age or &lt;1000 Grams Birth Weight: Study Protocol
Randomized Controlled Trial of Enteral Vitamin D Supplementation (ViDES) in Infants <28 Weeks Gestational Age or <1000 Grams Birth Weight: Study Protocol Open
Background Vitamin D is necessary to develop healthy lungs and other organs early in life. Most infants born before 28 weeks’ gestation have low vitamin D levels at birth and a limited intake during the first month. Enteral vitamin D suppl…
View article: Practical approaches for supporting informed consent in neonatal clinical trials
Practical approaches for supporting informed consent in neonatal clinical trials Open
The survival and health of preterm and critically ill infants have markedly improved over the past 50 years, supported by well‐conducted neonatal research. However, newborn research is difficult to undertake for many reasons, and obtaining…
View article: Social distancing and extremely preterm births in the initial COVID-19 pandemic period
Social distancing and extremely preterm births in the initial COVID-19 pandemic period Open
Hypothesis Increased social distancing was associated with a lower incidence of extremely preterm live births (EPLB) during the initial COVID-19 pandemic period. Study design Prospective study at the NICHD Neonatal Research Network sites c…
View article: Neonatal Intensive Care Unit Resource Use for Infants at 22 Weeks’ Gestation in the US, 2008-2021
Neonatal Intensive Care Unit Resource Use for Infants at 22 Weeks’ Gestation in the US, 2008-2021 Open
Importance During the past decade, clinical guidance about the provision of intensive care for infants born at 22 weeks’ gestation has changed. The impact of these changes on neonatal intensive care unit (NICU) resource utilization is unkn…
View article: Comparing methods for risk prediction of multicategory outcomes: dichotomized logistic regression vs. multinomial logit regression
Comparing methods for risk prediction of multicategory outcomes: dichotomized logistic regression vs. multinomial logit regression Open
View article: Secular Trends in Patent Ductus Arteriosus Management in Infants Born Preterm in the National Institute of Child Health and Human Development Neonatal Research Network
Secular Trends in Patent Ductus Arteriosus Management in Infants Born Preterm in the National Institute of Child Health and Human Development Neonatal Research Network Open
View article: Use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study
Use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study Open
Objective Extremely preterm (EP) impairment rates are likely underestimated using the Bayley III norm-based thresholds scores and may be better assessed relative to concurrent healthy term reference (TR) infants born in the same hospital. …
View article: Effect of reduced versus usual lipid emulsion dosing on bilirubin neurotoxicity and neurodevelopmental impairment in extremely preterm infants: study protocol for a randomized controlled trial
Effect of reduced versus usual lipid emulsion dosing on bilirubin neurotoxicity and neurodevelopmental impairment in extremely preterm infants: study protocol for a randomized controlled trial Open
Background Bilirubin neurotoxicity (BN) occurs in premature infants at lower total serum bilirubin levels than term infants and causes neurodevelopmental impairment. Usual dose lipid infusions in preterm infants may increase free fatty aci…
View article: Generalizability analyses with a partially nested trial design: the Necrotizing Enterocolitis Surgery Trial
Generalizability analyses with a partially nested trial design: the Necrotizing Enterocolitis Surgery Trial Open
We discuss generalizability analyses under a partially nested trial design, where part of the trial is nested within a cohort of trial-eligible individuals, while the rest of the trial is not nested. This design arises, for example, when o…
View article: Red Blood Cell Transfusion Thresholds for Anemia of Prematurity
Red Blood Cell Transfusion Thresholds for Anemia of Prematurity Open
Anemia of prematurity affects the majority of preterm infants, particularly extremely low birthweight infants. Anemia of prematurity arises from both innate and iatrogenic causes and results in more than 80% of extremely preterm infants re…
View article: Heterogeneity of Treatment Effects of Hydrocortisone by Risk of Bronchopulmonary Dysplasia or Death Among Extremely Preterm Infants in the National Institute of Child Health and Human Development Neonatal Research Network Trial
Heterogeneity of Treatment Effects of Hydrocortisone by Risk of Bronchopulmonary Dysplasia or Death Among Extremely Preterm Infants in the National Institute of Child Health and Human Development Neonatal Research Network Trial Open
Importance Extremely preterm infants who develop bronchopulmonary dysplasia (BPD) are at a higher risk for adverse pulmonary and neurodevelopmental outcomes. In the National Institute of Child Health and Human Development Neonatal Research…
View article: The evidence base for surgical treatment of infants with necrotizing enterocolitis or spontaneous intestinal perforation: Impact of trial design and questions regarding implementation of trial recommendations
The evidence base for surgical treatment of infants with necrotizing enterocolitis or spontaneous intestinal perforation: Impact of trial design and questions regarding implementation of trial recommendations Open
View article: Generalizability of the Necrotizing Enterocolitis Surgery Trial to the Target Population of Eligible Infants
Generalizability of the Necrotizing Enterocolitis Surgery Trial to the Target Population of Eligible Infants Open
View article: Assessment of Corticosteroid Therapy and Death or Disability According to Pretreatment Risk of Death or Bronchopulmonary Dysplasia in Extremely Preterm Infants
Assessment of Corticosteroid Therapy and Death or Disability According to Pretreatment Risk of Death or Bronchopulmonary Dysplasia in Extremely Preterm Infants Open
Importance Meta-analyses suggest that corticosteroids may be associated with increased survival without cerebral palsy in infants at high risk of bronchopulmonary dysplasia (BPD) but are associated with adverse neurologic outcomes in low-r…
View article: Evaluation of heterogeneity in effect of therapeutic hypothermia by sex among infants with neonatal encephalopathy
Evaluation of heterogeneity in effect of therapeutic hypothermia by sex among infants with neonatal encephalopathy Open
View article: Effect of Reduced Versus Usual Lipid Emulsion Dosing on Bilirubin Neurotoxicity and Neurodevelopmental Impairment in Extremely Preterm Infants: Study Protocol for a Randomized Controlled Trial
Effect of Reduced Versus Usual Lipid Emulsion Dosing on Bilirubin Neurotoxicity and Neurodevelopmental Impairment in Extremely Preterm Infants: Study Protocol for a Randomized Controlled Trial Open
Background : Bilirubin neurotoxicity ( BN ) occurs in premature infants at lower total serum bilirubin levels than term infants and causes neurodevelopmental impairment. Usual dose lipid infusions in preterm infants may increase free fatty…