Matthew A. Stott
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View article: Non-nucleoside reverse transcriptase inhibitor-based combination antiretroviral therapy is associated with lower cell-associated HIV RNA and DNA levels compared to protease inhibitor-based therapy
Non-nucleoside reverse transcriptase inhibitor-based combination antiretroviral therapy is associated with lower cell-associated HIV RNA and DNA levels compared to protease inhibitor-based therapy Open
Background: It remains unclear whether combination antiretroviral therapy (ART) regimens differ in their ability to fully suppress human immunodeficiency virus (HIV) replication. Here, we report the results of two cross-sectional studies t…
View article: Author response: Non-nucleoside reverse transcriptase inhibitor-based combination antiretroviral therapy is associated with lower cell-associated HIV RNA and DNA levels compared to protease inhibitor-based therapy
Author response: Non-nucleoside reverse transcriptase inhibitor-based combination antiretroviral therapy is associated with lower cell-associated HIV RNA and DNA levels compared to protease inhibitor-based therapy Open
Article Figures and data Abstract Introduction Materials and methods Results Discussion Data availability References Decision letter Author response Article and author information Metrics Abstract Background: It remains unclear whether com…
View article: Ultrasensitive detection of SARS-CoV-2 RNA and antigen using single-molecule optofluidic chip
Ultrasensitive detection of SARS-CoV-2 RNA and antigen using single-molecule optofluidic chip Open
Nucleic acids and proteins are the two most important target types used in molecular diagnostics. In many instances, simultaneous sensitive and accurate detection of both biomarkers from the same sample would be desirable, but standard det…
View article: Optofluidic multiplex detection of single SARS-CoV-2 and influenza A antigens using a novel bright fluorescent probe assay
Optofluidic multiplex detection of single SARS-CoV-2 and influenza A antigens using a novel bright fluorescent probe assay Open
Significance This work introduces an ultrasensitive single protein capture and detection technique based on a bright fluorescent reporter probe that is sensed on a photonic chip with integrated microfluidics. We perform differentiated dete…
View article: Optofluidic Amplification-Free Multiplex Detection of Viral Hemorrhagic Fevers
Optofluidic Amplification-Free Multiplex Detection of Viral Hemorrhagic Fevers Open
Infectious disease outbreaks such as Ebola and other Viral Hemorrhagic Fevers (VHF) require low-complexity, specific, and differentiated diagnostics as illustrated by the recent outbreak in the Democratic Republic of Congo. Here, we descri…
View article: 7X multiplexed, optofluidic detection of nucleic acids for antibiotic-resistance bacterial screening
7X multiplexed, optofluidic detection of nucleic acids for antibiotic-resistance bacterial screening Open
Rapid and accurate diagnosis of bacterial infections resistant to multiple antibiotics requires development of new bio-sensors for differentiated detection of multiple targets. This work demonstrates 7x multiplexed detection for antibiotic…
View article: 3× multiplexed detection of antibiotic resistant plasmids with single molecule sensitivity
3× multiplexed detection of antibiotic resistant plasmids with single molecule sensitivity Open
This work presents a rapid sample-to-answer system enabling multiplexed detection of three carbapenem antibiotic resistance plasmids with single molecule sensitivity.
View article: Optical trapping assisted detection rate enhancement of single molecules on a nanopore optofluidic chip
Optical trapping assisted detection rate enhancement of single molecules on a nanopore optofluidic chip Open
We use optical trapping to deliver molecular targets to the vicinity of a nanopore for high-throughput single molecule analysis on an optofluidic chip. DNA detection rates increase over 80× to enable detection at attomolar concentrations.
View article: Patterns of Co-occurring Comorbidities in People Living With HIV
Patterns of Co-occurring Comorbidities in People Living With HIV Open
Background The aims of this study were to identify common patterns of comorbidities observed in people living with HIV (PLWH), using a data-driven approach, and evaluate associations between patterns identified. Methods A wide range of com…
View article: Single-particle analysis with 2D electro-optical trapping on an integrated optofluidic device
Single-particle analysis with 2D electro-optical trapping on an integrated optofluidic device Open
Optical and optically assisted trapping has developed into an essential tool for studying and manipulating small objects with applications in numerous fields at the intersection of physics and the life sciences. Here, we report a waveguide…
View article: Optofluidic detection of Zika nucleic acid and protein biomarkers using multimode interference multiplexing
Optofluidic detection of Zika nucleic acid and protein biomarkers using multimode interference multiplexing Open
The recent massive Zika virus (ZIKV) outbreak illustrates the need for rapid and specific diagnostic techniques. Detecting ZIKV in biological samples poses unique problems: antibody detection of ZIKV is insufficient due to cross-reactivity…
View article: Multiplexed Optofluidics for Single-Molecule Analysis
Multiplexed Optofluidics for Single-Molecule Analysis Open
The rapid development of optofluidics, the combination of microfluidics and integrated optics, since its formal conception in the early 2000's has aided in the advance of single-molecule analysis. The optofluidic platform discussed in this…
View article: On-chip wavelength multiplexed detection of cancer DNA biomarkers in blood
On-chip wavelength multiplexed detection of cancer DNA biomarkers in blood Open
We have developed an optofluidic analysis system that processes biomolecular samples starting from whole blood and then analyzes and identifies multiple targets on a silicon-based molecular detection platform. We demonstrate blood filtrati…
View article: Optimization of Y-splitting antiresonant reflecting optical waveguides-based rib waveguides
Optimization of Y-splitting antiresonant reflecting optical waveguides-based rib waveguides Open
Antiresonant reflecting optical waveguide power splitters, designed for use around the 635-nm wavelength, are characterized for multiple split angles ranging from 0.5 deg to 9 deg. Theoretical expectations and simulations predict lowest tr…