Michael B. Smith
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View article: Phase 1 dose escalation trial of the selective adenosine A2B antagonist PBF-1129 in patients with metastatic non-small cell lung cancer
Phase 1 dose escalation trial of the selective adenosine A2B antagonist PBF-1129 in patients with metastatic non-small cell lung cancer Open
Summary The adenosinergic pathway represents a critical immunometabolic checkpoint within the tumor microenvironment of non-small cell lung cancer (NSCLC), contributing to immune suppression and therapeutic resistance. PBF-1129, an oral, s…
View article: Hot Flash Prediction for the Delivery of Just‐In‐Time Interventions
Hot Flash Prediction for the Delivery of Just‐In‐Time Interventions Open
During menopause, the majority of women experience hot flashes (HF) that have a significant negative impact on sleep and quality of life. Current HF therapies are either ineffective or associated with unacceptable side effects. Digital hea…
View article: Non-specific diagnostic labels for musculoskeletal conditions foster positive views about prognosis and non-invasive management but require clear explanation: a systematic review
Non-specific diagnostic labels for musculoskeletal conditions foster positive views about prognosis and non-invasive management but require clear explanation: a systematic review Open
CRD42024592437.
View article: 531 Novel inflammatory gene expression changes occur within the occluded vasculature of large vessel ischemic stroke
531 Novel inflammatory gene expression changes occur within the occluded vasculature of large vessel ischemic stroke Open
Objectives/Goals: We hypothesized that the bulk transcriptomic profiling of blood collected from within the ischemic vasculature during an acute ischemic stroke with large vessel occlusion (LVO) will contain unique biomarkers that are diff…
View article: Boosting REsources And caregiver empowerment for Tracheostomy care at HomE (BREATHE) Study: study protocol for a stratified randomization trial
Boosting REsources And caregiver empowerment for Tracheostomy care at HomE (BREATHE) Study: study protocol for a stratified randomization trial Open
View article: Tumor Embolic Stroke: The Importance of Pathological Assessment of Clots after Thrombectomy
Tumor Embolic Stroke: The Importance of Pathological Assessment of Clots after Thrombectomy Open
While tumor emboli are a rare cause of stroke in cancer patients, they highlight the importance of gross observations and pathological assessments in the evaluation of clots. In this case report, a 70-year-old male with type 2 diabetes mel…
View article: NUCLEAR POWER CONCEPTS FOR HIGH-POWER ELECTRIC PROPULSION MISSIONS TO MARS
NUCLEAR POWER CONCEPTS FOR HIGH-POWER ELECTRIC PROPULSION MISSIONS TO MARS Open
View article: Blood Pressure Management After Endovascular Therapy for Acute Ischemic Stroke
Blood Pressure Management After Endovascular Therapy for Acute Ischemic Stroke Open
Importance The effects of moderate systolic blood pressure (SBP) lowering after successful recanalization with endovascular therapy for acute ischemic stroke are uncertain. Objective To determine the futility of lower SBP targets after end…
View article: Patient and economic impact of implementing a paediatric sepsis pathway in emergency departments in Queensland, Australia
Patient and economic impact of implementing a paediatric sepsis pathway in emergency departments in Queensland, Australia Open
View article: Making it (net)work: a social network analysis of “fertility” in Twitter before and during the COVID-19 pandemic
Making it (net)work: a social network analysis of “fertility” in Twitter before and during the COVID-19 pandemic Open
View article: Identifying patients with symptoms suspicious for COVID-19 at elevated risk of adverse events: The COVAS score
Identifying patients with symptoms suspicious for COVID-19 at elevated risk of adverse events: The COVAS score Open
View article: Managing central venous access during a health care crisis
Managing central venous access during a health care crisis Open
View article: MAKING IT (NET)WORK: A SOCIAL NETWORK ANALYSIS OF “FERTILITY” ON TWITTER BEFORE AND DURING THE COVID-19 PANDEMIC
MAKING IT (NET)WORK: A SOCIAL NETWORK ANALYSIS OF “FERTILITY” ON TWITTER BEFORE AND DURING THE COVID-19 PANDEMIC Open
View article: Managing central venous access during a health care crisis
Managing central venous access during a health care crisis Open
View article: Hashtags and hatching: an analysis of information and influence in fertility-related social media
Hashtags and hatching: an analysis of information and influence in fertility-related social media Open
View article: Shear stress and aneurysms: a review
Shear stress and aneurysms: a review Open
Wall shear stress, the frictional force of blood flow tangential to an artery lumen, has been demonstrated in multiple studies to influence aneurysm formation and risk of rupture. In this article, the authors review the ways in which shear…
View article: Impact of functional magnetic resonance imaging (fMRI) scanner noise on affective state and attentional performance
Impact of functional magnetic resonance imaging (fMRI) scanner noise on affective state and attentional performance Open
The results of the present study suggest that the acoustic qualities of MRI enhance frustration effects on an affective attentional task and that scanner noise may influence mood during similar functional magnetic resonance imaging (fMRI) …