Matthew B. Wright
YOU?
Author Swipe
View article: Locked Down but Not Out: On-line Strength and Conditioning Provides A Viable Stimulus for Girls’ Football Players
Locked Down but Not Out: On-line Strength and Conditioning Provides A Viable Stimulus for Girls’ Football Players Open
Strength and conditioning is important for physical preparation in girls’ association football players however, during the COVID-19 pandemic on-line “virtual” coaching replaced gym sessions. Using an retrospective observational design we a…
View article: The KINETIC phase 2 randomized controlled trial of oral pamapimod-pioglitazone in non-critically ill COVID-19 inpatients
The KINETIC phase 2 randomized controlled trial of oral pamapimod-pioglitazone in non-critically ill COVID-19 inpatients Open
The combination of pamapimod and pioglitazone (KIN001) has a synergetic antiviral, anti-inflammatory, and antifibrotic activity, which may prevent evolution toward COVID-19-associated severe respiratory failure. In a randomized, placebo-co…
View article: 106 Establishing a Physiologically Relevant in Vitro Airway Model to Assess the Impacts of Environmental Exposures, Like Smoking, on Covid-19 Susceptibility.
106 Establishing a Physiologically Relevant in Vitro Airway Model to Assess the Impacts of Environmental Exposures, Like Smoking, on Covid-19 Susceptibility. Open
Air-liquid interface (ALI) cultures are commonly used for 3D modelling of the human airways and to examine the effects of direct exposure to airborne toxicants. We explored the suitability of human epithelial cell lines (RPMI 2560, HBEC-3K…
View article: Synergistic Antiviral Activity of Pamapimod and Pioglitazone against SARS-CoV-2 and Its Variants of Concern
Synergistic Antiviral Activity of Pamapimod and Pioglitazone against SARS-CoV-2 and Its Variants of Concern Open
The SARS-CoV-2 pandemic remains a major public health threat, especially due to newly emerging SARS-CoV-2 Variants of Concern (VoCs), which are more efficiently transmitted, more virulent, and more able to escape naturally acquired and vac…
View article: Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease
Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease Open
Impaired cellular cholesterol efflux is a key factor in the progression of renal, cardiovascular, and autoimmune diseases. Here we describe a class of 5-arylnicotinamide compounds, identified through phenotypic drug discovery, that upregul…
View article: Pioglitazone Ameliorates Gentamicin Ototoxicity by Affecting the TLR and STAT Pathways in the Early Postnatal Organ of Corti
Pioglitazone Ameliorates Gentamicin Ototoxicity by Affecting the TLR and STAT Pathways in the Early Postnatal Organ of Corti Open
Noise trauma, infection, and ototoxic drugs are frequent external causes of hearing loss. With no pharmacological treatments currently available, understanding the mechanisms and pathways leading to auditory hair cell (HC) damage and repai…
View article: Pioglitazone Represents an Effective Therapeutic Target in Preventing Oxidative/Inflammatory Cochlear Damage Induced by Noise Exposure
Pioglitazone Represents an Effective Therapeutic Target in Preventing Oxidative/Inflammatory Cochlear Damage Induced by Noise Exposure Open
Recent progress in hearing loss research has provided strong evidence for the imbalance of cellular redox status and inflammation as common predominant mechanisms of damage affecting the organ of Corti including noise induced hearing loss.…
View article: Effects of peroxisome proliferator activated receptors (PPAR)-γ and -α agonists on cochlear protection from oxidative stress
Effects of peroxisome proliferator activated receptors (PPAR)-γ and -α agonists on cochlear protection from oxidative stress Open
Various insults cause ototoxicity in mammals by increasing oxidative stress leading to apoptosis of auditory hair cells (HCs). The thiazolidinediones (TZDs; e.g., pioglitazone) and fibrate (e.g., fenofibrate) drugs are used for the treatme…
View article: Pasireotide prevents nuclear factor of activated T cells nuclear translocation and acts as a protective agent in aminoglycoside‐induced auditory hair cell loss
Pasireotide prevents nuclear factor of activated T cells nuclear translocation and acts as a protective agent in aminoglycoside‐induced auditory hair cell loss Open
Hearing impairment is a global health problem with a high socioeconomic impact. Damage to auditory hair cells (HCs) in the inner ear as a result of aging, disease, trauma, or toxicity, underlies the majority of cases of sensorineural heari…
View article: Dysfunctional Adipocytes in Cardiovascular Biology239PDE5 inhibition ameliorates visceral adiposity targeting the miR-22 / SIRT1 pathway: evidence from the CECSID trial237AMP-activated protein kinase activation partially restores the anti-contractile effect of perivascular adipose tissue in male offspring of obese dams238Peroxisome proliferator activated receptor (PPAR)alpha-gamma agonist aleglitazar attenuates tumor necrosis factor(TNF)alpha-mediated inflammation and insulin resistance in human adipocytes
Dysfunctional Adipocytes in Cardiovascular Biology239PDE5 inhibition ameliorates visceral adiposity targeting the miR-22 / SIRT1 pathway: evidence from the CECSID trial237AMP-activated protein kinase activation partially restores the anti-contractile effect of perivascular adipose tissue in male offspring of obese dams238Peroxisome proliferator activated receptor (PPAR)alpha-gamma agonist aleglitazar attenuates tumor necrosis factor(TNF)alpha-mediated inflammation and insulin resistance in human adipocytes Open
Background: Visceral adipose plays a significant role in cardiovascular risk. PDE5 inhibitors (PDE5i) can improve cardiac function and insulin sensitivity in type 2 diabetic patients (T2DM). Purpose: To investigate whether PDE5i affect vis…