Matthew Barron
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View article: Gut microbiome and bile acid changes after male rodent sleeve gastrectomy: what comes first?
Gut microbiome and bile acid changes after male rodent sleeve gastrectomy: what comes first? Open
We propose that the metabolic benefits of sleeve gastrectomy are initiated by decreased liver transcription of cyp8b1 and slc10a1. A notable downstream effect includes changes in systemic bile acid composition and circulation, including in…
View article: Sleeve Gastrectomy Protects Against Hypertension in Rats due to Changes in the Gut Microbiome
Sleeve Gastrectomy Protects Against Hypertension in Rats due to Changes in the Gut Microbiome Open
View article: Sleeve Gastrectomy Provides Cardioprotection from Oxidative Stress In Vitro Due to Reduction of Circulating Myeloperoxidase
Sleeve Gastrectomy Provides Cardioprotection from Oxidative Stress In Vitro Due to Reduction of Circulating Myeloperoxidase Open
Bariatric surgery, including sleeve gastrectomy (SG), improves systolic and diastolic function, which is independent of weight loss in rodent models. The cause of weight loss-independent improvements in cardiac function are unknown but may…
View article: Correction: A single, peri-operative antibiotic can persistently alter the post-operative gut microbiome after Roux-en-Y gastric bypass
Correction: A single, peri-operative antibiotic can persistently alter the post-operative gut microbiome after Roux-en-Y gastric bypass Open
View article: A single, peri-operative antibiotic can persistently alter the post-operative gut microbiome after Roux-en-Y gastric bypass
A single, peri-operative antibiotic can persistently alter the post-operative gut microbiome after Roux-en-Y gastric bypass Open
View article: Sleeve Gastrectomy Improves High-Fat Diet–Associated Hepatic Steatosis Independent of the Glucagon-like-Petpide-1 Receptor in Rats
Sleeve Gastrectomy Improves High-Fat Diet–Associated Hepatic Steatosis Independent of the Glucagon-like-Petpide-1 Receptor in Rats Open
View article: Serial evaluation of segmental esophageal reconstruction using a polyurethane scaffold in a pig model
Serial evaluation of segmental esophageal reconstruction using a polyurethane scaffold in a pig model Open
The PU scaffold provides a matrix across which formation of new tissue can occur. The mechanisms through which this happens remain unclear, but likely a combination of fibrosis and tissue contraction, in conjunction with new tissue formati…
View article: Sleeve gastrectomy prevents hypertension associated with unique shifts in the gut microbiome
Sleeve gastrectomy prevents hypertension associated with unique shifts in the gut microbiome Open
View article: Increasing Tau 4R Tau Levels Exacerbates Hippocampal Tau Hyperphosphorylation in the hTau Model of Tauopathy but Also Tau Dephosphorylation Following Acute Systemic Inflammation
Increasing Tau 4R Tau Levels Exacerbates Hippocampal Tau Hyperphosphorylation in the hTau Model of Tauopathy but Also Tau Dephosphorylation Following Acute Systemic Inflammation Open
Inflammation is considered a mechanistic driver of Alzheimer's disease, thought to increase tau phosphorylation, the first step to the formation of neurofibrillary tangles (NFTs). To further understand how inflammation impacts the developm…
View article: Long-term regeneration and remodeling of the pig esophagus after circumferential resection using a retrievable synthetic scaffold carrying autologous cells
Long-term regeneration and remodeling of the pig esophagus after circumferential resection using a retrievable synthetic scaffold carrying autologous cells Open
Treatment of esophageal disease can necessitate resection and reconstruction of the esophagus. Current reconstruction approaches are limited to utilization of an autologous conduit such as stomach, small bowel, or colon. A tissue engineere…
View article: NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy
NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy Open
View article: Patient‐ and Cell Type‐Specific Heterogeneity of Metformin Response
Patient‐ and Cell Type‐Specific Heterogeneity of Metformin Response Open
Most FDA ‐approved drugs are not equally effective in all patients, suggesting that identification of biomarkers to predict responders to a chemoprevention agent will be needed to stratify patients and achieve maximum benefit. The goal of …
View article: A state of delirium: Deciphering the effect of inflammation on tau pathology in Alzheimer's disease
A state of delirium: Deciphering the effect of inflammation on tau pathology in Alzheimer's disease Open
View article: Impaired burrowing is the most prominent behavioral deficit of aging htau mice
Impaired burrowing is the most prominent behavioral deficit of aging htau mice Open