Matthew Bianca
YOU?
Author Swipe
Cancer cell SMAD4 loss promotes tumor progression by modulating the tumor immune microenvironment in pancreatic ductal adenocarcinoma 2803 Open
Description Pancreatic cancer’s dismal 12% five-year survival rate urgently calls for a better understanding of the underlying tumor biology. KRAS, TP53, and SMAD4 mutations are frequent and are thought to be key disease drivers in the mos…
Defining molecular determinants of T cell spatial localization and clonal response throughout PDAC malignant progression 3030 Open
Description Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy, poised to become the second leading cause of cancer-related deaths in North America. The paucity of neoantigen presentation in PDAC has been hypothesize…
Modulation of cAMP metabolism for CFTR potentiation in human airway epithelial cells Open
Cystic fibrosis (CF) is a genetic disease characterized by CF transmembrane regulator (CFTR) dysfunction. With over 2000 CFTR variants identified, in addition to known patient to patient variability, there is a need for personalized treatm…