Matthew L. Broadhead
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View article: Bilateral ankle syndesmosis injury: a rare case report
Bilateral ankle syndesmosis injury: a rare case report Open
This report describes a case of bilateral acute ankle syndesmosis injuries in a 15-year-old male basketball player. The patient had a background of previous inversion injuries but no symptoms of chronic pain or instability. The case report…
View article: Clinical Features of High-Grade Extremity and Trunk Sarcomas in Patients Aged 80 Years and Older: Why Are Outcomes Inferior?
Clinical Features of High-Grade Extremity and Trunk Sarcomas in Patients Aged 80 Years and Older: Why Are Outcomes Inferior? Open
Background: The population of many countries is aging and a significant number of elderly patients with soft-tissue sarcoma are being seen at cancer centers. The unique therapeutic and prognostic implications of treating soft-tissue…
View article: Bilateral neck of femur fractures in a paediatric patient with graves' disease
Bilateral neck of femur fractures in a paediatric patient with graves' disease Open
A 13-year-old boy presented with bilateral neck of femur fractures on a background of Graves' disease. The fractures were sustained after minimal trauma, following a fall from standing height. The patient was unable to bear weight and soug…
View article: Osteosarcoma: From Molecular Biology to Mesenchymal Stem Cells
Osteosarcoma: From Molecular Biology to Mesenchymal Stem Cells Open
Osteosarcoma is the most common primary malignant tumour of bone. Currently, despite treatment with multi-agent chemotherapy and limb salvage surgery, the five-year survival rate for osteosarcoma remains at 70%. The pathogenesis of osteosa…
View article: Trauma and Stem Cells: Biology and Potential Therapeutic Implications
Trauma and Stem Cells: Biology and Potential Therapeutic Implications Open
Trauma may cause irreversible tissue damage and loss of function despite current best practice. Healing is dependent both on the nature of the injury and the intrinsic biological capacity of those tissues for healing. Preclinical research …
View article: A biomechanical comparison of 4-strand and 5-strand anterior cruciate ligament graft constructs
A biomechanical comparison of 4-strand and 5-strand anterior cruciate ligament graft constructs Open
Hamstring tendon autografts are used for reconstruction of the anterior cruciate ligament. This study tested the hypothesis that a 5-strand hamstring autograft construct is superior in strength to a 4-strand construct. Four-strand and 5-st…
View article: Applying Advanced Imaging Techniques to a Murine Model of Orthotopic Osteosarcoma
Applying Advanced Imaging Techniques to a Murine Model of Orthotopic Osteosarcoma Open
Application of [(18)F]-Fluoride-PET and [(18)F]-FDG-PET to an established murine model of orthotopic osteosarcoma has improved the assessment of disease. The use of targeted imaging should prove beneficial for the evaluation of new approac…