Matthew C. Arvin
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View article: IFN-α Induces Heterogenous ROS Production in Human β-Cells
IFN-α Induces Heterogenous ROS Production in Human β-Cells Open
Type 1 diabetes (T1D) is a multifactorial disease involving genetic and environmental factors, including viral infection. We investigated the impact of interferon alpha (IFN-α), a cytokine produced during the immune response to viral infec…
View article: Factor VIII Trafficking to CD4+ T cells Shapes its Immunogenicity and Requires Several Types of Antigen Presenting Cells
Factor VIII Trafficking to CD4+ T cells Shapes its Immunogenicity and Requires Several Types of Antigen Presenting Cells Open
Despite over 80 years of clinical experience with coagulation factor (F)VIII inhibitors, surprisingly little is known about the in vivo mechanism of this most serious complication of replacement therapy for hemophilia A. These neutralizing…
View article: SERCA2 regulates proinsulin processing and processing enzyme maturation in the pancreatic β cell
SERCA2 regulates proinsulin processing and processing enzyme maturation in the pancreatic β cell Open
Increased circulating levels of incompletely processed insulin (i.e. proinsulin) are observed clinically in both type 1 and type 2 diabetes; however, the mechanisms underlying impaired proinsulin processing remain incompletely understood. …
View article: Chronic Nicotine Exposure Alters the Neurophysiology of Habenulo-Interpeduncular Circuitry
Chronic Nicotine Exposure Alters the Neurophysiology of Habenulo-Interpeduncular Circuitry Open
Antagonism of nicotinic acetylcholine receptors (nAChRs) in the medial habenula (MHb) or interpeduncular nucleus (IPN) triggers withdrawal-like behaviors in mice chronically exposed to nicotine, implying that nicotine dependence involves t…
View article: Probing Nicotinic Acetylcholine Receptor Function in Mouse Brain Slices via Laser Flash Photolysis of Photoactivatable Nicotine
Probing Nicotinic Acetylcholine Receptor Function in Mouse Brain Slices via Laser Flash Photolysis of Photoactivatable Nicotine Open
Acetylcholine (ACh) acts through receptors to modulate a variety of neuronal processes, but it has been challenging to link ACh receptor function with subcellular location within cells where this function is carried out. To study the subce…
View article: An Optopharmacological Interrogation of Nicotinic Acetylcholine Receptor Subcellular Localization, Regulation, and Function
An Optopharmacological Interrogation of Nicotinic Acetylcholine Receptor Subcellular Localization, Regulation, and Function Open
Smoking is directly responsible for lung cancer, respiratory disease, and cardiovascular disease. It follows that smoking is known to be the greatest preventable causes of disease, disability, and death. In light of the harmful effects of …
View article: Nicotinic Cholinergic Receptors in VTA Glutamate Neurons Modulate Excitatory Transmission
Nicotinic Cholinergic Receptors in VTA Glutamate Neurons Modulate Excitatory Transmission Open
Ventral tegmental area (VTA) glutamate neurons are important components of reward circuitry, but whether they are subject to cholinergic modulation is unknown. To study this, we used molecular, physiological, and photostimulation technique…
View article: Nicotinic cholinergic receptors in VTA glutamate neurons modulate excitatory transmission
Nicotinic cholinergic receptors in VTA glutamate neurons modulate excitatory transmission Open
Summary Ventral tegmental area (VTA) glutamate neurons are important components of brain reward circuitry, but whether they are subject to cholinergic modulation is unknown. To study this, we used an array of molecular, physiological, and …
View article: Development of photoactivatable drugs enables nicotinic optopharmacology
Development of photoactivatable drugs enables nicotinic optopharmacology Open
Photoactivatable (‘caged’) pharmacological agents have revolutionized neuroscience but the palette of available ligands is limited. We describe a general method for caging tertiary amines using an unconventional quaternary ammonium linkage…
View article: Altered nicotine reward-associated behavior following α4 nAChR subunit deletion in ventral midbrain
Altered nicotine reward-associated behavior following α4 nAChR subunit deletion in ventral midbrain Open
Nicotinic acetylcholine receptors containing α4 subunits (α4β2* nAChRs) are critical for nicotinic cholinergic transmission and the addictive action of nicotine. To identify specific activities of these receptors in the adult mouse brain, …