Matthew Colpus
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View article: Rapidly and reproducibly building a comprehensive catalogue of resistance-associated variants for <i>M. tuberculosis</i>
Rapidly and reproducibly building a comprehensive catalogue of resistance-associated variants for <i>M. tuberculosis</i> Open
Background Catalogues of genetic variants associated with resistance underpin whole-genome sequencing (WGS)-based predictions of drug susceptibility in Mycobacterium tuberculosis , and are essential for molecular diagnostics and surveillan…
View article: Escherichia coli phylogeny drives co-amoxiclav resistance through variable expression of TEM-1 beta-lactamase
Escherichia coli phylogeny drives co-amoxiclav resistance through variable expression of TEM-1 beta-lactamase Open
Co-amoxiclav (amoxicillin and clavulanate) is a commonly used combination antibiotic, with resistance in Escherichia coli associated with increased mortality. The class A beta-lactamase bla TEM-1 is often carried by resistant E. coli but e…
View article: Characterising the performance of an antibiotic resistance prediction tool, gnomonicus, using a diverse testset of 2,663 <i>Mycobacterium tuberculosis</i> samples
Characterising the performance of an antibiotic resistance prediction tool, gnomonicus, using a diverse testset of 2,663 <i>Mycobacterium tuberculosis</i> samples Open
Tuberculosis remains a global health problem. Making it easier and quicker to identify which antibiotics an infection is likely to be susceptible to will be a key part of the solution. Whilst whole-genome sequencing offers many advantages,…
View article: <i>E. coli</i>phylogeny drives co-amoxiclav resistance through variable expression of<i>bla</i><sub>TEM-1</sub>
<i>E. coli</i>phylogeny drives co-amoxiclav resistance through variable expression of<i>bla</i><sub>TEM-1</sub> Open
Co-amoxiclav resistance in E. coli is a clinically important phenotype associated with increased mortality. The class A beta-lactamase bla TEM-1 is often carried by co- amoxiclav-resistant pathogens, but exhibits high phenotypic heterogene…
View article: Evaluation of the accuracy of bacterial genome reconstruction with Oxford Nanopore R10.4.1 long-read-only sequencing
Evaluation of the accuracy of bacterial genome reconstruction with Oxford Nanopore R10.4.1 long-read-only sequencing Open
Whole-genome reconstruction of bacterial pathogens has become an important tool for tracking transmission and antimicrobial resistance gene spread, but highly accurate and complete assemblies have largely only historically been achievable …
View article: Evaluation of the accuracy of bacterial genome reconstruction with Oxford Nanopore R10.4.1 long-read-only sequencing
Evaluation of the accuracy of bacterial genome reconstruction with Oxford Nanopore R10.4.1 long-read-only sequencing Open
2. Abstract Whole genome reconstruction of bacterial pathogens has become an import tool for tracking antimicrobial resistance spread, however accurate and complete assemblies have only been achievable using hybrid long and short-read sequ…
View article: Anticipated Coverage of the ExPEC9V Vaccine Amongst Global Urinary Tract and Bloodstream Infection-associated Escherichia Coli
Anticipated Coverage of the ExPEC9V Vaccine Amongst Global Urinary Tract and Bloodstream Infection-associated Escherichia Coli Open
View article: non_entero_assemblies.tar.gz
non_entero_assemblies.tar.gz Open
All non enterobase assemblies used in serotyping study