Matthew Cook
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View article: Improving Situational Awareness During Interfacility Transport Using a Transport Monitoring and Communication Application: A Simulation-Based Pilot Study
Improving Situational Awareness During Interfacility Transport Using a Transport Monitoring and Communication Application: A Simulation-Based Pilot Study Open
Objectives: To evaluate the impact of using a simulated teletransport application compared with ad hoc phone calls between medical control physicians (MCP) and transport teams on situational awareness and communication during neonatal inte…
View article: Advanced immunophenotyping of lymphocyte and monocyte subsets in healthy Australian adults using a novel spectral flow cytometry panel
Advanced immunophenotyping of lymphocyte and monocyte subsets in healthy Australian adults using a novel spectral flow cytometry panel Open
Introduction Lymphocytes play pivotal roles in disease pathogenesis and can be used as potential biomarkers for various immunological conditions. Yet, current flow cytometry methods used in clinical settings are often only capable of measu…
View article: Single-centre comparison of non-familial, familial and monogenic lupus
Single-centre comparison of non-familial, familial and monogenic lupus Open
Objectives There is a significant genetic contribution to systemic lupus erythematosus (SLE). Monogenic SLE is a distinct form of SLE. We investigated whether familial or known monogenic lupus cases are distinguishable from non-familial lu…
View article: Event driven neural network on a mixed signal neuromorphic processor for EEG based epileptic seizure detection
Event driven neural network on a mixed signal neuromorphic processor for EEG based epileptic seizure detection Open
Long-term monitoring of biomedical signals is essential for the modern clinical management of neurological conditions such as epilepsy. However, developing wearable systems that are able to monitor, analyze, and detect epileptic seizures w…
View article: Point prevalence surveys of acute infection presentation and antibiotic prescribing in selected primary healthcare facilities in North-West and Gauteng provinces of South Africa
Point prevalence surveys of acute infection presentation and antibiotic prescribing in selected primary healthcare facilities in North-West and Gauteng provinces of South Africa Open
Background: The effective management of infections is threatened by antimicrobial resistance (AMR), with an estimated 1.27 million deaths directly attributed to AMR in 2019. There are concerns with antibiotic prescribing in ambulatory care…
View article: Universality Frontier for Asynchronous Cellular Automata
Universality Frontier for Asynchronous Cellular Automata Open
In this work, we investigate the computational aspects of asynchronous cellular automata (ACAs), a modification of cellular automata in which cells update independently, following an asynchronous schedule. We introduce flip automata networ…
View article: Loss of <scp>CXCR5</scp> expression and monocyte epithelial–mesenchymal transition are blood‐borne signatures of sterile granulomatous diseases
Loss of <span>CXCR5</span> expression and monocyte epithelial–mesenchymal transition are blood‐borne signatures of sterile granulomatous diseases Open
Objectives Sarcoidosis is the exemplar sterile granulomatous disease and can affect any organ system. Tattoo uveitis (TU) resembles sarcoidosis clinically and histologically but is distinguished by the absence of systemic lymphadenopathy, …
View article: Learning Equivariant Maps with Variational Quantum Circuits
Learning Equivariant Maps with Variational Quantum Circuits Open
Geometric quantum machine learning uses the symmetries inherent in data to design tailored machine learning tasks with reduced search space dimension. The field has been well-studied recently in an effort to avoid barren plateau issues whi…
View article: Transdisciplinary Analysis of System Endurance due to Imbalanced Engineering Capability Using 3PE Modelling Framework
Transdisciplinary Analysis of System Endurance due to Imbalanced Engineering Capability Using 3PE Modelling Framework Open
System endurance characterises how long the system can remain operational without requiring external interference. This concept is particularly important for mission critical systems, where an essential requirement is to stay on mission as…
View article: Whole exome sequencing in patients with childhood‐onset systemic lupus erythematosus: Results from a Croatian national study
Whole exome sequencing in patients with childhood‐onset systemic lupus erythematosus: Results from a Croatian national study Open
The purpose of this study was to identify new and low‐frequency gene variants using whole exome sequencing (WES) in patients with childhood‐onset systemic lupus erythematosus (cSLE), that may be involved in the pathogenesis of SLE. We perf…
View article: Molecular Determinants of Autoimmunity and Immune Related Adverse Events in Advanced Cancer Patients Treated with Immune Checkpoint Inhibitors (Auto-Check Study)
Molecular Determinants of Autoimmunity and Immune Related Adverse Events in Advanced Cancer Patients Treated with Immune Checkpoint Inhibitors (Auto-Check Study) Open
Molecular Determinants of Autoimmunity and Immune Related Adverse Events in Advanced Cancer Patients Treated with Immune Checkpoint Inhibitors (Auto-Check Study)
View article: Event Driven Neural Network on a Mixed Signal Neuromorphic Processor for EEG Based Epileptic Seizure Detection
Event Driven Neural Network on a Mixed Signal Neuromorphic Processor for EEG Based Epileptic Seizure Detection Open
Long-term monitoring of biomedical signals is essential for the modern clinical management of neurological conditions such as epilepsy. However, developing wearable systems that are able to monitor, analyze, and detect epileptic seizures w…
View article: L-plastin associated syndrome of immune deficiency and hematologic cytopenia
L-plastin associated syndrome of immune deficiency and hematologic cytopenia Open
We describe a unique human hematopoietic defect affecting neutrophils, lymphocytes, and platelets arising from partial LCP1 deficiency.
View article: Diagnostic delay of sarcoidosis: an integrated systematic review
Diagnostic delay of sarcoidosis: an integrated systematic review Open
Background Sarcoidosis is a chronic inflammatory granulomatous disease of unknown cause. Delays in diagnosis can result in disease progression and poorer outcomes for patients. Our aim was to review the current literature to determine the …
View article: Learning with SASQuaTCh: a Novel Variational Quantum Transformer Architecture with Kernel-Based Self-Attention
Learning with SASQuaTCh: a Novel Variational Quantum Transformer Architecture with Kernel-Based Self-Attention Open
The recent exploding growth in size of state-of-the-art machine learning models highlights a well-known issue where exponential parameter growth, which has grown to trillions as in the case of the Generative Pre-trained Transformer (GPT), …
View article: The Role of β-Dystroglycan in Nuclear Dynamics
The Role of β-Dystroglycan in Nuclear Dynamics Open
Dystroglycan is a ubiquitously expressed heterodimeric cell-surface laminin receptor with roles in cell adhesion, signalling, and membrane stabilisation. More recently, the transmembrane β-subunit of dystroglycan has been shown to localise…
View article: Rare <i>SH2B3</i> coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity
Rare <i>SH2B3</i> coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity Open
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with a clear genetic component. While most SLE patients carry rare gene variants in lupus risk genes, little is known about their contribution to disease pathogenesis…
View article: Acquired Angioedema Associated with Lymphoproliferative Disorders
Acquired Angioedema Associated with Lymphoproliferative Disorders Open
Introduction: Acquired angioedema due to C1 esterase inhibitor deficiency (C1INH-AAE) is most associated with lymphoproliferative disorders (LPDs), particularly low-grade B-cell subtypes. The condition remains under-recognized with long di…
View article: DECTIN-1: A modifier protein in CTLA-4 haploinsufficiency
DECTIN-1: A modifier protein in CTLA-4 haploinsufficiency Open
Autosomal dominant loss-of-function (LoF) variants in cytotoxic T-lymphocyte associated protein 4 ( CTLA4 ) cause immune dysregulation with autoimmunity, immunodeficiency and lymphoproliferation (IDAIL). Incomplete penetrance and variable …
View article: Omitted Labels Induce Nontransitive Paradoxes in Causality
Omitted Labels Induce Nontransitive Paradoxes in Causality Open
We explore "omitted label contexts," in which training data is limited to a subset of the possible labels. This setting is standard among specialized human experts or specific, focused studies. By studying Simpson's paradox, we observe tha…
View article: An Approach to Innovative Design Within Complex Projects with the Application of TRIZ-3PE
An Approach to Innovative Design Within Complex Projects with the Application of TRIZ-3PE Open
For innovative design to succeed within a complex project environment, it is essential to resolve contradictions and facilitate dynamic engagement across domains. This need is being further challenged by the growing strategy that large org…
View article: IKK2 controls the inflammatory potential of tissue-resident regulatory T cells
IKK2 controls the inflammatory potential of tissue-resident regulatory T cells Open
Loss-of-function mutations have provided crucial insights into the immunoregulatory actions of Foxp3 + regulatory T cells (Tregs). By contrast, we know very little about the consequences of defects that amplify aspects of Treg function or …
View article: Ataxia telangiectasia and juvenile idiopathic arthritis: A coincidence or a relationship?
Ataxia telangiectasia and juvenile idiopathic arthritis: A coincidence or a relationship? Open
The data that support the findings of this study are available upon request from the corresponding author, MJ. These data are not publicly available due to their containing information that could compromise the privacy of research particip…
View article: PB2278: ACQUIRED ANGIOEDEMA ASSOCIATED WITH LYMPHOPROLIFERATIVE DISORDERS: A CASE SERIES
PB2278: ACQUIRED ANGIOEDEMA ASSOCIATED WITH LYMPHOPROLIFERATIVE DISORDERS: A CASE SERIES Open
Topic: 18. Indolent and mantle-cell non-Hodgkin lymphoma - Clinical Background: Acquired angioedema due to C1 esterase inhibitor deficiency (C1INH-AAE) is most associated with lymphoproliferative disorders (LPD) particularly low-grade B-LP…