Matthew D. Rand
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View article: Reflections on the NIEHS Virtual Consortium funding mechanism (ViCTER) and what it has taught us about the future of transdisciplinary science
Reflections on the NIEHS Virtual Consortium funding mechanism (ViCTER) and what it has taught us about the future of transdisciplinary science Open
In environmental health science, collaboration across disciplines is often encouraged but rarely specifically solicited through funding mechanisms. The United States National Institute of Environmental Health Sciences (NIEHS) Virtual Conso…
View article: Review: myogenic and muscle toxicity targets of environmental methylmercury exposure
Review: myogenic and muscle toxicity targets of environmental methylmercury exposure Open
View article: KEAP1 polymorphisms and neurodevelopmental outcomes in children with exposure to prenatal MeHg from the Seychelles Child Development Study Nutrition Cohort 2
KEAP1 polymorphisms and neurodevelopmental outcomes in children with exposure to prenatal MeHg from the Seychelles Child Development Study Nutrition Cohort 2 Open
View article: Postnatal methylmercury exposure and neurodevelopmental outcomes at 7 years of age in the Seychelles Child Development Study Nutrition Cohort 2
Postnatal methylmercury exposure and neurodevelopmental outcomes at 7 years of age in the Seychelles Child Development Study Nutrition Cohort 2 Open
View article: Perspectives on the <i>Drosophila melanogaster</i> Model for Advances in Toxicological Science
Perspectives on the <i>Drosophila melanogaster</i> Model for Advances in Toxicological Science Open
The use of Drosophila melanogaster for studies of toxicology has grown considerably in the last decade. The Drosophila model has long been appreciated as a versatile and powerful model for developmental biology and genetics because of its …
View article: Assessing the role of the gut microbiome in methylmercury demethylation and elimination in humans and gnotobiotic mice
Assessing the role of the gut microbiome in methylmercury demethylation and elimination in humans and gnotobiotic mice Open
View article: Targeted Intracellular Demethylation of Methylmercury Enhances Elimination Kinetics and Reduces Developmental Toxicity in Transgenic<i>Drosophila</i>
Targeted Intracellular Demethylation of Methylmercury Enhances Elimination Kinetics and Reduces Developmental Toxicity in Transgenic<i>Drosophila</i> Open
Methylmercury (MeHg) persists today as a priority public health concern. Mechanisms influencing MeHg metabolism, kinetics, and toxicity outcomes are therefore essential knowledge for informing exposure risks. Evidence points to different t…
View article: Contribution of child ABC-transporter genetics to prenatal MeHg exposure and neurodevelopment
Contribution of child ABC-transporter genetics to prenatal MeHg exposure and neurodevelopment Open
These findings support the possibility that child ABC genetics might influence prenatal MeHg exposure.
View article: Organomercurial Lyase (MerB)-Mediated Demethylation Decreases Bacterial Methylmercury Resistance in the Absence of Mercuric Reductase (MerA)
Organomercurial Lyase (MerB)-Mediated Demethylation Decreases Bacterial Methylmercury Resistance in the Absence of Mercuric Reductase (MerA) Open
Mercury is a globally distributed pollutant that poses a risk to wildlife and human health. The toxicity of mercury is influenced largely by microbially mediated biotransformation between its organic (methylmercury) and inorganic [Hg(II) a…
View article: Developmental Toxicology of Metal Mixtures in Drosophila: Unique Properties of Potency and Interactions of Mercury Isoforms
Developmental Toxicology of Metal Mixtures in Drosophila: Unique Properties of Potency and Interactions of Mercury Isoforms Open
Mercury ranks third on the U.S. Agency of Toxic Substances and Disease Registry priority list of hazardous substances, behind only arsenic and lead. We have undertaken uncovering the mechanisms underlying the developmental toxicity of meth…
View article: Latent effects of early-life methylmercury exposure on motor function in Drosophila
Latent effects of early-life methylmercury exposure on motor function in Drosophila Open
View article: Delivery Mode and Child Development at 20 Months of Age and 7 Years of Age in the Republic of Seychelles
Delivery Mode and Child Development at 20 Months of Age and 7 Years of Age in the Republic of Seychelles Open
View article: Neuroligin-1 Is a Mediator of Methylmercury Neuromuscular Toxicity
Neuroligin-1 Is a Mediator of Methylmercury Neuromuscular Toxicity Open
Methylmercury (MeHg) is a developmental toxicant capable of eliciting neurocognitive and neuromuscular deficits in children with in utero exposure. Previous research in Drosophila melanogaster uncovered that developmental MeHg exposure sim…
View article: Variation in Methylmercury Metabolism and Elimination in Humans: Physiological Pharmacokinetic Modeling Highlights the Role of Gut Biotransformation, Skeletal Muscle, and Hair
Variation in Methylmercury Metabolism and Elimination in Humans: Physiological Pharmacokinetic Modeling Highlights the Role of Gut Biotransformation, Skeletal Muscle, and Hair Open
The biological half-life (t1/2) of methylmercury (MeHg) shows considerable individual variability (t1/2 < 30 to > 120 days), highlighting the importance of mechanisms controlling MeHg metabolism and elimination. Building on a prior p…
View article: Associations of prenatal methylmercury exposure and maternal polyunsaturated fatty acid status with neurodevelopmental outcomes at 7 years of age: results from the Seychelles Child Development Study Nutrition Cohort 2
Associations of prenatal methylmercury exposure and maternal polyunsaturated fatty acid status with neurodevelopmental outcomes at 7 years of age: results from the Seychelles Child Development Study Nutrition Cohort 2 Open
View article: Tissue-specific Nrf2 signaling protects against methylmercury toxicity in Drosophila neuromuscular development
Tissue-specific Nrf2 signaling protects against methylmercury toxicity in Drosophila neuromuscular development Open
View article: Methylmercury myotoxicity targets formation of the myotendinous junction
Methylmercury myotoxicity targets formation of the myotendinous junction Open
View article: Developmental exposure to methylmercury and resultant muscle mercury accumulation and adult motor deficits in mice
Developmental exposure to methylmercury and resultant muscle mercury accumulation and adult motor deficits in mice Open
View article: Development of Human Hair Reference Material Supporting the Biomonitoring of Methylmercury
Development of Human Hair Reference Material Supporting the Biomonitoring of Methylmercury Open
View article: Methylmercury modifies temporally expressed myogenic regulatory factors to inhibit myoblast differentiation
Methylmercury modifies temporally expressed myogenic regulatory factors to inhibit myoblast differentiation Open
View article: Drosophotoxicology: Elucidating Kinetic and Dynamic Pathways of Methylmercury Toxicity in a Drosophila Model
Drosophotoxicology: Elucidating Kinetic and Dynamic Pathways of Methylmercury Toxicity in a Drosophila Model Open
The risks of methylmercury (MeHg) toxicity are greatest during early life where it has long been appreciated that the developing nervous system is an especially sensitive target. Yet, understanding the discrete mechanisms of MeHg toxicity …
View article: Associations of blood mercury and fatty acid concentrations with blood mitochondrial DNA copy number in the Seychelles Child Development Nutrition Study
Associations of blood mercury and fatty acid concentrations with blood mitochondrial DNA copy number in the Seychelles Child Development Nutrition Study Open
Our findings suggest that MeHg and PUFA may influence mitochondrial homeostasis although the magnitude of these associations are small. Future studies should confirm the findings and explore the underlying mechanisms.
View article: Maternal polymorphisms in glutathione-related genes are associated with maternal mercury concentrations and early child neurodevelopment in a population with a fish-rich diet
Maternal polymorphisms in glutathione-related genes are associated with maternal mercury concentrations and early child neurodevelopment in a population with a fish-rich diet Open
View article: Notch Target Gene E(spl)mδ Is a Mediator of Methylmercury-Induced Myotoxicity in Drosophila
Notch Target Gene E(spl)mδ Is a Mediator of Methylmercury-Induced Myotoxicity in Drosophila Open
Methylmercury (MeHg) is a ubiquitous environmental contaminant and neurotoxicant that has long been known to cause a variety of motor deficits. These motor deficits have primarily been attributed to MeHg targeting of developing neurons and…
View article: Methylmercury exposure causes a persistent inhibition of myogenin expression and C2C12 myoblast differentiation
Methylmercury exposure causes a persistent inhibition of myogenin expression and C2C12 myoblast differentiation Open
View article: Editor’s Highlight: Variation in Methylmercury Metabolism and Elimination Status in Humans Following Fish Consumption
Editor’s Highlight: Variation in Methylmercury Metabolism and Elimination Status in Humans Following Fish Consumption Open
Evaluating the potential for methylmercury (MeHg) toxicity relies on accurately predicting the mercury (Hg) body burden that results from eating fish. Hg body burden is directly determined by the slow elimination kinetics of MeHg in the hu…
View article: CYP3A genes and the association between prenatal methylmercury exposure and neurodevelopment
CYP3A genes and the association between prenatal methylmercury exposure and neurodevelopment Open
Our results suggest that the polymorphisms in CYP3A genes may modify the response to dietary MeHg exposure during early life development.
View article: Editor's Highlight: Glutathione S-Transferase Activity Moderates Methylmercury Toxicity During Development in Drosophila
Editor's Highlight: Glutathione S-Transferase Activity Moderates Methylmercury Toxicity During Development in Drosophila Open
Glutathione (GSH) pathways play a central role in methylmercury (MeHg) metabolism and elimination, largely due to formation of a more readily transported MeHg-GSH conjugate. Glutathione S-transferases (GSTs) have therefore been proposed to…
View article: Polymorphisms in ATP-binding cassette transporters associated with maternal methylmercury disposition and infant neurodevelopment in mother-infant pairs in the Seychelles Child Development Study
Polymorphisms in ATP-binding cassette transporters associated with maternal methylmercury disposition and infant neurodevelopment in mother-infant pairs in the Seychelles Child Development Study Open
Genetic variation in ABC transporter genes was associated with maternal hair Hg concentrations. The implications for MeHg dose in the developing child and neurodevelopmental outcomes need to be further investigated.