Matthew D Sadler
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View article: Dedicated Automatic Recall Hepatocellular Cancer Surveillance Programme Demonstrates High Retention: A Population‐Based Cohort Study
Dedicated Automatic Recall Hepatocellular Cancer Surveillance Programme Demonstrates High Retention: A Population‐Based Cohort Study Open
Introduction Patient, clinician, and system‐related barriers may affect adherence to hepatocellular carcinoma (HCC) surveillance programmes. The impact of a dedicated automated recall HCC surveillance programme on retention rates in patien…
View article: DNMT3A-mutant clonal haematopoiesis and the recovery of patients with acute ST-elevation myocardial infarction
DNMT3A-mutant clonal haematopoiesis and the recovery of patients with acute ST-elevation myocardial infarction Open
Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): British Heart foundation Background Haematopoietic stem cells can acquire mutations and produce mutant blood cells. When this occurs in the absence of ov…
View article: Reversal of Hypertensive Cardiomyopathy on Antihypertensive Therapy - A CMR Case Presentation
Reversal of Hypertensive Cardiomyopathy on Antihypertensive Therapy - A CMR Case Presentation Open
View article: Systemic cytokine and viral antigen-specific responses in hepatitis D virus RNA positive versus HDV RNA negative patients
Systemic cytokine and viral antigen-specific responses in hepatitis D virus RNA positive versus HDV RNA negative patients Open
Background Hepatitis B virus (HBV)/Hepatitis D Virus (HDV) co-infection increases the risk of severe liver disease compared to HBV mono-infection. Adaptive immune responses to HDV are weakly detectable, and the involvement of innate immuni…
View article: P1340: MONOCYTE-DRIVEN INFLAMMATION IN DNMT3A-MUTANT CLONAL HAEMATOPOIESIS ACUTE ST-ELEVATION MYOCARDIAL INFARCTION.
P1340: MONOCYTE-DRIVEN INFLAMMATION IN DNMT3A-MUTANT CLONAL HAEMATOPOIESIS ACUTE ST-ELEVATION MYOCARDIAL INFARCTION. Open
Topic: 23. Hematopoiesis, stem cells and microenvironment Background: In clonal haematopoiesis of indeterminate potential (CHIP), haematopoietic stem cells acquire mutations and produce mutant blood cells without overt blood disease. CHIP …
View article: Increased hospital admissions for alcohol-associated hepatitis during the COVID-19 pandemic in Alberta, Canada: a retrospective cohort study
Increased hospital admissions for alcohol-associated hepatitis during the COVID-19 pandemic in Alberta, Canada: a retrospective cohort study Open
View article: Real-world tertiary referral centre experience stopping nucleos(t)ide analogue therapy in patients with chronic hepatitis B
Real-world tertiary referral centre experience stopping nucleos(t)ide analogue therapy in patients with chronic hepatitis B Open
BACKGROUND: Identifying strategies for stopping nucleos(t)ide analogues (NUC) in patients with chronic hepatitis B (CHB) is a major goal in CHB management. Our study describes our tertiary-centre experience stopping nucleos(t)ide analogues…
View article: Tu1261: IMPACT OF THE COVID-19 PANDEMIC ON THE EPIDEMIOLOGY OF ALCOHOL-ASSOCIATED HEPATITIS
Tu1261: IMPACT OF THE COVID-19 PANDEMIC ON THE EPIDEMIOLOGY OF ALCOHOL-ASSOCIATED HEPATITIS Open
View article: Molecular epidemiology and clinical characteristics of hepatitis D virus infection in Canada
Molecular epidemiology and clinical characteristics of hepatitis D virus infection in Canada Open
Evidence of HDV infection was observed in approximately 5% of Canadians who were infected with HBV referred to medical specialists. HDV-positive patients were more likely to be male, born in Canada, or White or Black/African/Caribbean comp…
View article: A202 IMPACT OF THE COVID-19 PANDEMIC ON THE EPIDEMIOLOGY OF ALCOHOL-RELATED HEPATITIS
A202 IMPACT OF THE COVID-19 PANDEMIC ON THE EPIDEMIOLOGY OF ALCOHOL-RELATED HEPATITIS Open
Background Alcohol-related hepatitis (AH) is the most severe form of alcohol-related liver disease, with rising incidence. Stay-at-home orders for the COVID-19 pandemic were associated with increased alcohol consumption. Online sales repor…
View article: Impact of the COVID-19 Pandemic on Hospitalizations for Alcoholic Hepatitis or Cirrhosis in Alberta, Canada
Impact of the COVID-19 Pandemic on Hospitalizations for Alcoholic Hepatitis or Cirrhosis in Alberta, Canada Open
View article: A210 DECLINE IN HEPATITIS B QUANTITATIVE SURFACE ANTIGEN LEVELS IN CHRONIC HEPATITIS B PATIENTS ON TREATMENT WITH NUCLEOS(T)IDE ANALOGUES
A210 DECLINE IN HEPATITIS B QUANTITATIVE SURFACE ANTIGEN LEVELS IN CHRONIC HEPATITIS B PATIENTS ON TREATMENT WITH NUCLEOS(T)IDE ANALOGUES Open
Background The Hepatitis B virus (HBV) affects over 250 million people worldwide and can lead to cirrhosis and hepatocellular carcinoma. HBV surface antigen (HBsAg) quantification is increasingly used to predict disease activity and treatm…
View article: Assessment of Canadian policies regarding liver transplant candidacy of people who use alcohol, tobacco, cannabis, and opiates
Assessment of Canadian policies regarding liver transplant candidacy of people who use alcohol, tobacco, cannabis, and opiates Open
BACKGROUND: When last assessed in 2013, all Canadian liver transplant programs required 6 months of abstinence from alcohol. New studies have questioned the validity of this policy. Moreover, with recreational cannabis now legal in Canada,…
View article: Evaluating the role of transient elastography post chronic hepatitis C treatment to predict hepatocellular carcinoma
Evaluating the role of transient elastography post chronic hepatitis C treatment to predict hepatocellular carcinoma Open
View article: The cirrhosis care Alberta (CCAB) protocol: implementing an evidence-based best practice order set for the management of liver cirrhosis - a hybrid type I effectiveness-implementation trial
The cirrhosis care Alberta (CCAB) protocol: implementing an evidence-based best practice order set for the management of liver cirrhosis - a hybrid type I effectiveness-implementation trial Open
Background Liver cirrhosis is a leading cause of morbidity, premature mortality and acute care utilization in patients with digestive disease. In the province of Alberta, hospital readmission rates for patients with cirrhosis are estimated…
View article: Practical management of esophageal varices in the context of SARS-CoV-2 (COVID-19): the Alberta protocol
Practical management of esophageal varices in the context of SARS-CoV-2 (COVID-19): the Alberta protocol Open
The challenges of managing varices during the COVID-19 pandemic are reviewed, and a treatment algorithm is presented to best manage patients with advanced liver disease during periods of limited access to endoscopy.
View article: Importance of fibrosis stage in starting treatment for hepatitis B virus (HBV): Are the updated CASL/AMMI HBV clinical algorithms lost in translation?
Importance of fibrosis stage in starting treatment for hepatitis B virus (HBV): Are the updated CASL/AMMI HBV clinical algorithms lost in translation? Open
Keywords: fibrosis; guidelines; hepatitis B virus, knowledge translation, treatment Author Affiliation
View article: Transient Elastography in the Evaluation of Cystic Fibrosis–Associated Liver Disease: Systematic Review and Meta-analysis
Transient Elastography in the Evaluation of Cystic Fibrosis–Associated Liver Disease: Systematic Review and Meta-analysis Open
Individually, LSM and APRI have poor sensitivity but good specificity for detecting CFLD. They are most useful when combined. We propose that patients with LSM ≥5.95 kPa and APRI ≥0.329 be investigated thoroughly for the presence of cystic…
View article: Editorial: genotype 3 <scp>HCV</scp>—who still needs ribavirin in a pan‐genotypic era?
Editorial: genotype 3 <span>HCV</span>—who still needs ribavirin in a pan‐genotypic era? Open
Linked Content This article is linked to von Felden et al papers. To view these articles visit https://doi.org/10.1111/apt.14592 and https://doi.org/10.1111/apt.14648 .
View article: Treatment of Genotype 3 Chronic Hepatitis C Virus Infection
Treatment of Genotype 3 Chronic Hepatitis C Virus Infection Open
Genotype 3 (GT3) hepatitis C virus (HCV), the second most common HCV genotype worldwide, has emerged as the most difficult-to-cure genotype. Sustained virological response (SVR) rates with new direct-acting antiviral regimens for GT3 patie…
View article: Revolution in hepatitis C antiviral therapy
Revolution in hepatitis C antiviral therapy Open
HCV genotype 3 is the new difficult-to-treat genotype. More efficacious regimens for treating HCV genotype 3 are needed. Subgroups of patients who only require even shorter regimens of 6-8 weeks need to be identified. There is still very l…
View article: Noninvasive Methods, including Transient Elastography, for the Detection of Liver Disease in Adults with Cystic Fibrosis
Noninvasive Methods, including Transient Elastography, for the Detection of Liver Disease in Adults with Cystic Fibrosis Open
BACKGROUND: Liver disease is the third leading cause of mortality in patients with cystic fibrosis (CF). However, detection of CF-associated liver disease (CFLD) is challenging. OBJECTIVE: To evaluate the diagnostic performance of noninvas…