Matthew E. Merritt
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View article: Pharmacokinetic modeling strategies for dynamic hyperpolarized urea imaging
Pharmacokinetic modeling strategies for dynamic hyperpolarized urea imaging Open
Purpose To evaluate pharmacokinetic modeling methods for quantification of tissue perfusion/permeability with hyperpolarized 13 C urea. Methods Three models for quantitative analysis of dynamic HP urea imaging data were proposed and evalua…
View article: Metabolic flux analysis of glioblastoma neural stem cells reveals distinctive metabolic phenotypes in ketogenic conditions
Metabolic flux analysis of glioblastoma neural stem cells reveals distinctive metabolic phenotypes in ketogenic conditions Open
Glioblastomas (GBM) are the most prevalent primary brain tumors, affecting 5 in every 100,000 people. GBMs optimize proliferation through adaptive cellular metabolism, frequently exploiting the Warburg effect by increasing aerobic glycolys…
View article: Assessing cancer therapeutic efficacy in vivo using [ <sup>2</sup> H <sub>7</sub> ]glucose deuterium metabolic imaging
Assessing cancer therapeutic efficacy in vivo using [ <sup>2</sup> H <sub>7</sub> ]glucose deuterium metabolic imaging Open
Metabolic imaging produces powerful visual assessments of organ function in vivo. Current techniques can be improved by safely increasing metabolic contrast. The gold standard, 2-[ 18 F]fluorodeoxyglucose-positron emission tomography (FDG-…
View article: Detecting altered hepatic lipid oxidation by MRI in an animal model of MASLD
Detecting altered hepatic lipid oxidation by MRI in an animal model of MASLD Open
Metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence is increasing annually and affects over a third of US adults. MASLD can progress to metabolic dysfunction-associated steatohepatitis (MASH), characterized by sever…
View article: DIPG-18. MULTIMODALITY VISUALIZATION OF A PRECLINICAL MODEL OF DIFFUSE MIDLINE GLIOMA DEMONSTRATES CLEAR TREATMENT EFFECT AFTER RNA NANOPARTICLE THERAPY
DIPG-18. MULTIMODALITY VISUALIZATION OF A PRECLINICAL MODEL OF DIFFUSE MIDLINE GLIOMA DEMONSTRATES CLEAR TREATMENT EFFECT AFTER RNA NANOPARTICLE THERAPY Open
BACKGROUND Diffuse Midline Glioma (DMG) is an inoperable pediatric brain tumor with insufficient treatment options. Our group has developed a novel treatment modality for this disease and others, using mRNA vaccines consisting of tumor der…
View article: A global view of T cell metabolism in systemic lupus erythematosus
A global view of T cell metabolism in systemic lupus erythematosus Open
Impaired metabolism is recognized as an important contributor to pathogenicity of T cells in Systemic Lupus Erythematosus (SLE). Over the last two decades, we have acquired significant knowledge about the signaling and transcriptomic progr…
View article: Inactivation of mitochondrial MUL1 E3 ubiquitin ligase deregulates mitophagy and prevents diet-induced obesity in mice
Inactivation of mitochondrial MUL1 E3 ubiquitin ligase deregulates mitophagy and prevents diet-induced obesity in mice Open
Obesity is a growing epidemic affecting millions of people worldwide and a major risk factor for a multitude of chronic diseases and premature mortality. Accumulating evidence suggests that mitochondria have a profound role in diet-induced…
View article: Age-related differences in affective behaviors in mice: possible role of prefrontal cortical-hippocampal functional connectivity and metabolomic profiles
Age-related differences in affective behaviors in mice: possible role of prefrontal cortical-hippocampal functional connectivity and metabolomic profiles Open
Introduction The differential expression of emotional reactivity from early to late adulthood may involve maturation of prefrontal cortical responses to negative valence stimuli. In mice, age-related changes in affective behaviors have bee…
View article: P188: Synchronized long-read genome, methylene, epigenome, and transcriptome for a putative small fiber peripheral polyneuropathy research study
P188: Synchronized long-read genome, methylene, epigenome, and transcriptome for a putative small fiber peripheral polyneuropathy research study Open
Rare and inherited diseases (RID), while low in prevalence, collectively impact hundreds of millions of people globally. Some RID are well-characterized, while others are ultra- or hyper-rare, making identification and classification extre…
View article: MetaVision3D: Automated Framework for the Generation of Spatial Metabolome Atlas in 3D
MetaVision3D: Automated Framework for the Generation of Spatial Metabolome Atlas in 3D Open
High-resolution spatial imaging is transforming our understanding of foundational biology. Spatial metabolomics is an emerging field that enables the dissection of the complex metabolic landscape and heterogeneity from a thin tissue sectio…
View article: Age-Related Differences in Affective Behaviors in Mice: Possible Role of Prefrontal Cortical-Hippocampal Functional Connectivity and Metabolomic Profiles
Age-Related Differences in Affective Behaviors in Mice: Possible Role of Prefrontal Cortical-Hippocampal Functional Connectivity and Metabolomic Profiles Open
The differential expression of emotional reactivity from early to late adulthood may involve maturation of prefrontal cortical responses to negative valence stimuli. In mice, age-related changes in affective behaviors have been reported, b…
View article: Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples
Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples Open
Stable isotopes are powerful tools to assess metabolism. 13C labeling is detected using nuclear magnetic resonance (NMR) spectroscopy or mass spectrometry (MS). MS has excellent sensitivity but generally cannot discriminate among different…
View article: Detecting altered hepatic lipid oxidation by MRI in an animal model of NAFLD
Detecting altered hepatic lipid oxidation by MRI in an animal model of NAFLD Open
Nonalcoholic fatty liver disease (NAFLD) prevalence is increasing annually and affects over a third of U.S. adults. NAFLD can progress to nonalcoholic steatohepatitis (NASH), characterized by severe inflammation and fibrosis. NASH is predi…
View article: Spatial Metabolome Lipidome and Glycome from a Single brain Section
Spatial Metabolome Lipidome and Glycome from a Single brain Section Open
Metabolites, lipids, and glycans are fundamental biomolecules involved in complex biological systems. They are metabolically channeled through a myriad of pathways and molecular processes that define the physiology and pathology of an orga…
View article: Observing exocrine pancreas metabolism using a novel pancreas perfusion technique in combination with hyperpolarized [1‐<sup>13</sup>C]pyruvate
Observing exocrine pancreas metabolism using a novel pancreas perfusion technique in combination with hyperpolarized [1‐<sup>13</sup>C]pyruvate Open
In a clinical setting, ex vivo perfusions are routinely used to maintain and assess organ viability prior to transplants. Organ perfusions are also a model system to examine metabolic flux while retaining the local physiological structure,…
View article: Metabolomic Profiling of Asparagine Deprivation in Asparagine Synthetase Deficiency Patient-Derived Cells
Metabolomic Profiling of Asparagine Deprivation in Asparagine Synthetase Deficiency Patient-Derived Cells Open
The natural amino acid asparagine (Asn) is required by cells to sustain function and proliferation. Healthy cells can synthesize Asn through asparagine synthetase (ASNS) activity, whereas specific cancer and genetically diseased cells are …
View article: Table S3 from Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation
Table S3 from Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation Open
Table S3 shows sequences of primers and shRNAs
View article: Table S1 from Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation
Table S1 from Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation Open
Table S1 shows the list of genomic datasets
View article: Table S2 from Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation
Table S2 from Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation Open
Table S2 shows differentially expressed genes by RNA-seq
View article: Table S3 from Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation
Table S3 from Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation Open
Table S3 shows sequences of primers and shRNAs
View article: Table S1 from Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation
Table S1 from Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation Open
Table S1 shows the list of genomic datasets
View article: Supplementary Figures and Legends from Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation
Supplementary Figures and Legends from Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation Open
Supplementary Figures and Legends combined file contains 14 supplementary figures
View article: Supplementary Figures and Legends from Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation
Supplementary Figures and Legends from Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation Open
Supplementary Figures and Legends combined file contains 14 supplementary figures
View article: Table S4 from Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation
Table S4 from Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation Open
Table S4 shows key reagents and resources
View article: Table S2 from Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation
Table S2 from Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation Open
Table S2 shows differentially expressed genes by RNA-seq