Matthew E. Pope
YOU?
Author Swipe
View article: Development and translation of a method of clinical utility for LC-MS/MS analysis to detect SARS-CoV-2 antigens from ONP swabs and saliva
Development and translation of a method of clinical utility for LC-MS/MS analysis to detect SARS-CoV-2 antigens from ONP swabs and saliva Open
During the COVID-19 pandemic, development of diagnostic tests was vital to chart the course and to reduce the impact of the infection. Continued testing and surveillance of vaccine escape will continue for years to come which presents an o…
View article: Rapid and Sensitive Detection of SARS-CoV-2 Infection Using Quantitative Peptide Enrichment LC-MS Analysis
Rapid and Sensitive Detection of SARS-CoV-2 Infection Using Quantitative Peptide Enrichment LC-MS Analysis Open
Reliable, robust, large-scale molecular testing for SARS-CoV-2 is essential for monitoring the ongoing Covid-19 pandemic. We have developed a scalable analytical approach to detect viral proteins based on peptide immunoaffinity enrichment …
View article: Precision Multiparameter Tracking of Inflammation on Timescales of Hours to Years Using Serial Dried Blood Spots
Precision Multiparameter Tracking of Inflammation on Timescales of Hours to Years Using Serial Dried Blood Spots Open
Aim: High-frequency longitudinal tracking of inflammation using dried blood microsamples provides a new window for personalized monitoring of infections, chronic inflammatory disease and clinical trials of anti-inflammatory drugs. Results/…
View article: Precision Multiparameter Tracking of Inflammation on Timescales of Hours to Years Using Serial Dried Blood Spots
Precision Multiparameter Tracking of Inflammation on Timescales of Hours to Years Using Serial Dried Blood Spots Open
High-frequency longitudinal tracking of inflammation using dried blood microsamples provides a new window for personalized monitoring of infections, chronic inflammatory disease, and clinical trials of anti-inflammatory drugs. Using 1,662 …
View article: Multiplexed measurement of protein biomarkers in high-frequency longitudinal dried blood spot (DBS) samples: characterization of inflammatory responses
Multiplexed measurement of protein biomarkers in high-frequency longitudinal dried blood spot (DBS) samples: characterization of inflammatory responses Open
A detailed understanding of changes in blood protein biomarkers occuring in individuals over time would enable truly personalized approaches to health and disease monitoring. Such measurements could reveal smaller, earlier departures from …
View article: Multiplexed Longitudinal Measurement of Protein Biomarkers in DBS Using an Automated Siscapa Workflow
Multiplexed Longitudinal Measurement of Protein Biomarkers in DBS Using an Automated Siscapa Workflow Open
The results showed that after normalizing the spot-to-spot hematocrit variations, peptide surrogates of protein biomarkers could be accurately quantitated in DBS. This allowed the establishment of baselines for a variety of biomarkers in m…
View article: Characterization of Calflagin, a Flagellar Calcium-Binding Protein from Trypanosoma congolense
Characterization of Calflagin, a Flagellar Calcium-Binding Protein from Trypanosoma congolense Open
While calflagin is conserved among different species of African trypanosomes, our results show that T. congolense calflagin possesses unique epitopes that differentiate this protein from homologues in other trypanosome species. MAb Tc6/42.…