Matthew E. Thornton
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View article: Heterogeneous origins and functions of lung mesenchymal stromal cells
Heterogeneous origins and functions of lung mesenchymal stromal cells Open
View article: Yb2-Tb Upconversion in a Hetero-Trimetallic Molecular Lanthanide Complex
Yb2-Tb Upconversion in a Hetero-Trimetallic Molecular Lanthanide Complex Open
Photon Upconversion in molecular hetero-metallic lanthanide systems is challenged by the lack of chemical diversity displayed by the lanthanide ions. Here, we report the multi-photon photophysical properties of a series of molecular hetero…
View article: Multicellular tumor-stromal interactions recapitulate aspects of therapeutic response and human oncogenic signaling in a 3D disease model for H3K27M-altered DIPG
Multicellular tumor-stromal interactions recapitulate aspects of therapeutic response and human oncogenic signaling in a 3D disease model for H3K27M-altered DIPG Open
It has become evident from decades of clinical trials that multimodal therapeutic approaches with focus on cell intrinsic and microenvironmental cues are needed to improve understanding and treat the rare, inoperable, and ultimately fatal …
View article: RNA in Plasma Extracellular Vesicles of Adolescent Rhesus Macaques Reveal Immune, Bioenergetic, and Microbial Imprints of Early-Life Adversity: An Exploratory Analysis
RNA in Plasma Extracellular Vesicles of Adolescent Rhesus Macaques Reveal Immune, Bioenergetic, and Microbial Imprints of Early-Life Adversity: An Exploratory Analysis Open
View article: Controlling nephron precursor differentiation to generate proximal-biased kidney organoids with emerging maturity
Controlling nephron precursor differentiation to generate proximal-biased kidney organoids with emerging maturity Open
The kidney maintains fluid homeostasis by reabsorbing essential compounds and excreting waste. Proximal tubule cells, crucial for reabsorbing sugars, ions, and amino acids, are highly susceptible to injury, often leading to pathologies nec…
View article: Axial nephron fate switching demonstrates a plastic system tunable on demand
Axial nephron fate switching demonstrates a plastic system tunable on demand Open
View article: Author response: Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features
Author response: Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features Open
View article: Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features
Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features Open
Human cone photoreceptors differ from rods and serve as the retinoblastoma cell-of-origin, yet the developmental basis for their distinct behaviors is poorly understood. Here, we used deep full-length single-cell RNA-sequencing (scRNA-seq)…
View article: Author response: Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features
Author response: Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features Open
View article: Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features
Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features Open
Human cone photoreceptors differ from rods and serve as the retinoblastoma cell-of-origin, yet the developmental basis for their distinct behaviors is poorly understood. Here, we used deep full-length single-cell RNA-sequencing (scRNA-seq)…
View article: Axial Nephron Fate Switching Demonstrates a Plastic System Tunable on Demand
Axial Nephron Fate Switching Demonstrates a Plastic System Tunable on Demand Open
SUMMARY The human nephron is a highly patterned tubular structure. It develops specialized cells that regulate bodily fluid homeostasis, blood pressure, and urine secretion throughout life. Approximately 1 million nephrons form in each kid…
View article: Small RNAs regulation and genomic harmony: insights into allopolyploid evolution in marsh orchids (<i>Dactylorhiza</i>)
Small RNAs regulation and genomic harmony: insights into allopolyploid evolution in marsh orchids (<i>Dactylorhiza</i>) Open
Summary Hybridization and polyploidy are major drivers of plant diversification, often leading to novel ecological traits through changes in gene regulation. Among these, small RNAs (smRNAs) play a key role, particularly through their inte…
View article: Defining and Controlling Axial Nephron Patterning in Human Kidney Organoids with Synthetic Wnt-Secreting Organizers
Defining and Controlling Axial Nephron Patterning in Human Kidney Organoids with Synthetic Wnt-Secreting Organizers Open
Current human pluripotent stem cell-derived kidney organoids contain nephron-like structures that lack organotypic patterning. It is thought that during human development, nephrons form their proximal-distal axial polarity in response to c…
View article: Author response: Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features
Author response: Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features Open
View article: Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features
Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features Open
Human cone photoreceptors differ from rods and serve as the retinoblastoma cell-of-origin. Here, we used deep full-length single-cell RNA-sequencing to distinguish post-mitotic cone and rod developmental states and cone-specific features t…
View article: Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features
Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features Open
Human cone photoreceptors differ from rods and serve as the retinoblastoma cell-of-origin, yet the developmental basis for their distinct behaviors is poorly understood. Here, we used deep full-length single-cell RNA-sequencing (scRNA-seq)…
View article: Stepwise developmental mimicry generates proximal-biased kidney organoids
Stepwise developmental mimicry generates proximal-biased kidney organoids Open
The kidney maintains body fluid homeostasis by reabsorbing essential compounds and excreting waste. Proximal tubule cells, crucial for renal reabsorption of a range of sugars, ions, and amino acids, are highly susceptible to damage, leadin…
View article: Author response: Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts
Author response: Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts Open
View article: Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts
Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts Open
Abnormal lung development can cause congenital pulmonary cysts, the mechanisms of which remain largely unknown. Although the cystic lesions are believed to result directly from disrupted airway epithelial cell growth, the extent to which d…
View article: Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts
Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts Open
Summary Abnormal lung development can cause congenital pulmonary cysts, the mechanisms of which remain largely unknown. Although the cystic lesions are believed to result directly from disrupted airway epithelial cell growth, the extent to…
View article: Author response: Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts
Author response: Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts Open
View article: The role of social media on psychological wellbeing from the perspectives of young people with type 1 diabetes and their caregivers: a qualitative study
The role of social media on psychological wellbeing from the perspectives of young people with type 1 diabetes and their caregivers: a qualitative study Open
This study explores the perceived influence of social media on psychological wellbeing in young people living with type 1 diabetes. Young people aged 13–20 years (N = 19) with type 1 diabetes and caregivers (diabetes healthcare providers a…
View article: 341 Amylase and phospholipase A2 levels in human amniotic fluid of fetuses with open spina bifida
341 Amylase and phospholipase A2 levels in human amniotic fluid of fetuses with open spina bifida Open
View article: Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts
Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts Open
Abnormal lung development can cause congenital pulmonary cysts, the mechanisms of which remain largely unknown. Although the cystic lesions are believed to result directly from disrupted airway epithelial cell growth, the extent to which d…
View article: Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts
Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts Open
Summary Abnormal lung development can cause congenital pulmonary cysts, the mechanisms of which remain largely unknown. Although the cystic lesions are believed to result directly from disrupted airway epithelial cell growth, the extent to…
View article: Reviewer #1 (Public Review): Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts
Reviewer #1 (Public Review): Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts Open
Abnormal lung development can cause congenital pulmonary cysts, the mechanisms of which remain largely unknown. Although the cystic lesions are believed to result directly from disrupted airway epithelial cell growth, the extent to which d…
View article: Reviewer #2 (Public Review): Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts
Reviewer #2 (Public Review): Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts Open
Abnormal lung development can cause congenital pulmonary cysts, the mechanisms of which remain largely unknown. Although the cystic lesions are believed to result directly from disrupted airway epithelial cell growth, the extent to which d…
View article: Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts
Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts Open
Summary Abnormal lung development can cause congenital pulmonary cysts, the mechanisms of which remain largely unknown. Although the cystic lesions are believed to result directly from disrupted airway epithelial cell growth, the extent to…
View article: Single-nuclei multiomic analyses identify human cardiac lymphatic endothelial cells associated with coronary arteries in the epicardium
Single-nuclei multiomic analyses identify human cardiac lymphatic endothelial cells associated with coronary arteries in the epicardium Open
Cardiac lymphatic vessels play important roles in fluid homeostasis, inflammation, disease, and regeneration of the heart. The developing cardiac lymphatics in human fetal hearts are closely associated with coronary arteries, similar to th…
View article: Mitochondria Transplantation Mitigates Damage in an In Vitro Model of Renal Tubular Injury and in an Ex Vivo Model of DCD Renal Transplantation
Mitochondria Transplantation Mitigates Damage in an In Vitro Model of Renal Tubular Injury and in an Ex Vivo Model of DCD Renal Transplantation Open
Objectives: To test whether mitochondrial transplantation (MITO) mitigates damage in 2 models of acute kidney injury (AKI). Background: MITO is a process where exogenous isolated mitochondria are taken up by cells. As virtually any morbid …