Matthew E. Winter
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View article: Data from TGFβ1-Mediated SMAD3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer
Data from TGFβ1-Mediated SMAD3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer Open
Programmed death-1 (PD-1) is a coinhibitory receptor that downregulates the activity of tumor-infiltrating lymphocytes (TIL) in cancer and of virus-specific T cells in chronic infection. The molecular mechanisms driving high PD-1 expressio…
View article: Data from TGFβ1-Mediated SMAD3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer
Data from TGFβ1-Mediated SMAD3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer Open
Programmed death-1 (PD-1) is a coinhibitory receptor that downregulates the activity of tumor-infiltrating lymphocytes (TIL) in cancer and of virus-specific T cells in chronic infection. The molecular mechanisms driving high PD-1 expressio…
View article: Supplementary Figure Legends, Figures 1 - 5 from TGFβ1-Mediated SMAD3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer
Supplementary Figure Legends, Figures 1 - 5 from TGFβ1-Mediated SMAD3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer Open
Supplementary Figure 1. The effect of various cytokines on PD-1 expression is shown as fold changes in MFI relative to the αCD3/αCD28 condition with no cytokines in both CD4+ (black bars) 4 and CD8+ (white bars) T cells. Supplementary Figu…
View article: Supplementary Figure Legends, Figures 1 - 5 from TGFβ1-Mediated SMAD3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer
Supplementary Figure Legends, Figures 1 - 5 from TGFβ1-Mediated SMAD3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer Open
Supplementary Figure 1. The effect of various cytokines on PD-1 expression is shown as fold changes in MFI relative to the αCD3/αCD28 condition with no cytokines in both CD4+ (black bars) 4 and CD8+ (white bars) T cells. Supplementary Figu…
View article: Randomized Trial of a Vaccine Regimen to Prevent Chronic HCV Infection
Randomized Trial of a Vaccine Regimen to Prevent Chronic HCV Infection Open
BackgroundA safe and effective vaccine to prevent chronic hepatitis C virus (HCV) infection is a critical component of efforts to eliminate the disease.MethodsIn this phase 1-2 randomized, double-blind, placebo-controlled trial, we evaluat…