Explanipedia

Long-term quality of life in head and neck cancer: the role of postdiagnosis smoking behavior Open

Elham Mohebbi, Alaina L. Carr, Garret Guthrie, Siddhi Patil, E. Clementi , et al. · 2025

Purpose Head and neck squamous cell carcinoma (HNSCC) significantly impacts patients’ quality of life (QoL). This study investigated long-term QoL outcomes among 619 patients with newly diagnosed HNSCC over five years. Methods QoL was asse…

Gyroscopic Stereotactic Radiosurgery: A Retrospective Analysis Open

Dylan R Conroy, Susan M Woody, Ying Niu, Yuan E Yuan, Keith Unger , et al. · 2025

Introduction Stereotactic radiosurgery (SRS) is a safe and effective non-invasive treatment for both primary and secondary brain tumors. Recently, a gyroscopic frameless, self-contained, and self-shielded radiosurgery system has been clini…

Optimizing quality assurance CT schedules during adaptive proton therapy for enhanced patient care Open

Nrusingh C. Biswal, Mark J. Zakhary, Abdul K. Parchur, Ruslan Mogilnay, Matthew J. Ferris , et al. · 2025

Purpose This study aims to optimize the frequency of routine quality assurance CT (QACT) scans in proton beam therapy (PBT) for brain, head and neck (HN), and prostate treatments. The goal is to enhance treatment efficiency without comprom…

Postdiagnosis Smoking Cessation and Survival Outcomes of Head and Neck Cancer Patients Open

Elham Mohebbi, Garret Guthrie, Siddhi Patil, William J. Benjamin, Ming Tan , et al. · 2025

Background Post‐diagnosis smoking remains prevalent among head and neck squamous cell carcinoma (HNSCC) patients. Smoking cessation may improve patient outcomes. Methods A prospective longitudinal cohort study (2008–2014) included 835 newl…

The acute changes in parameters of cardiac implantable electronic devices in patients undergoing radiation therapy Open

Aleksandra Błachut, Maciej Dyrbuś, Joanna Machowicz, A. Kurek, Tomasz Rutkowski , et al. · 2025

Background The number of patients with cardiac implantable electronic devices (CIEDs) requiring effective cancer treatment, including radiotherapy (RT), is increasing year by year. A potentially harmful effect of RT on CIEDs depending on t…

Pencil Beam Scanning Proton Therapy as Single Vocal Cord Irradiation for Early-Stage Glottic Cancer Open

Bansi Savla, J. Jatczak, Jason K. Molitoris, Matthew E. Witek, Kimberly Marter , et al. · 2024

Proton therapy re-irradiation outcomes and genomic landscape of patients with recurrent head and neck cancer Open

Rebecca Krc, William Mendes, Jason K. Molitoris, Matthew J. Ferris, Yang Song , et al. · 2024

PBS-PT is effective at achieving LC for rHNC with favorable toxicity. Distant metastases are common, and associated with TP53, NOTCH4, and ARID1B mutations. Inclusion of genomic alterations in the clinical decision process may be warranted.

Cone-Beam CT Images as an Indicator of QACT During Adaptive Proton Therapy of Extremity Sarcomas Open

Nrusingh C. Biswal, Baoshe Zhang, E.M. Nichols, Matthew E. Witek, William F. Regine , et al. · 2024

The use of BPL changes on CBCT images represented a significant reduction (85%) in total QACT burden while maintaining treatment quality and accuracy. QACT can be performed only when it is needed, but not in a periodic manner. The benefits…

Streamlining treatment plan evaluations on QACTs in adaptive proton radiotherapy using standardized review criteria Open

Nrusingh C. Biswal, S. Mossahebi, Weiguang Yao, H. Zhang, William F. Regine , et al. · 2024

A Longitudinal Metagenomic Comparative Analysis of Oral Microbiome Shifts in Patients Receiving Proton Radiation Versus Photon Radiation for Head and Neck Cancer Open

Timothy F. Meiller, Claire M. Fraser, Silvia Grant-Beurmann, Mike Humphrys, Luke J. Tallon , et al. · 2023

Introduction: Due to the radiation-sparing effects on salivary gland acini, changes in the composition of the oral microbiome may be a driver for improved outcomes in patients receiving proton radiation with potentially worse outcomes in p…

Is noncoplanar plan more robust to inter‐fractional variations than coplanar plan in treating bilateral HN tumors with pencil‐beam scanning proton beams? Open

B Yi, J. Jatczak, Wei Deng, Yannick Poirier, Weiguang Yao , et al. · 2023

Purpose Noncoplanar plans (NCPs) are commonly used for proton treatment of bilateral head and neck (HN) malignancies. NCP requires additional verification setup imaging between beams to correct residual errors of robotic couch motion, whic…

Post-treatment PET/CT for p16-positive oropharynx cancer treated with definitive proton therapy Open

Gregory S. Alexander, Ariel Pollock, Danielle Arons, Matthew J. Ferris, Jason K. Molitoris , et al. · 2023

Objectives: Given emerging data suggesting that uncertainty in the relative biologic effectiveness at the distal end of the Bragg peak results in increased mucosal injury in patients with oropharynx cancer receiving adjuvant proton therapy…

Positive Predictive Value of PET CT in HPV Associated Oropharyngeal Cancers Treated with Definitive Proton Therapy Open

Gregory S. Alexander, Ariel Pollock, Danielle Arons, D. Alicia, Jason K. Molitoris , et al. · 2023

Histology Specific Molecular Biomarkers: Ushering in a New Era of Precision Radiation Oncology Open

Philip Sutera, Heath D. Skinner, Matthew E. Witek, Mark V. Mishra, Young Kwok , et al. · 2023

Interstitial Brachytherapy for Lip Cancer: Technical Aspects to Individualize Treatment Approach and Optimize Outcomes Open

Emily Merfeld, Matthew E. Witek, David M. Francis, A. Burr, Charles R. Wallace , et al. · 2023

Regionalization of Head and Neck Oncology Tumor Boards: Perspectives of Collaborating Physicians Open

Neha Amin, Kelly Bridgham, Jessica Brown, Kelly F. Moyer, Rodney J. Taylor , et al. · 2023

Objectives To survey academic and community physician preferences regarding the virtual multidisciplinary tumor board (MTB) for further improvement and expansion. Study Design This anonymous 14‐question survey was sent to individuals that …

Patterns of failure for hypopharynx cancer patients treated with limited high-dose radiotherapy treatment volumes Open

A. Burr, Paul M. Harari, Aaron M. Wieland, Randall J. Kimple, Gregory K. Hartig , et al. · 2022

Purpose: Optimal radiotherapy treatment volumes for patients with locally advanced hypopharynx squamous cell carcinoma should ensure maximal tumor coverage with minimal inclusion of normal surrounding structures. Here we evaluated the effe…

Evaluation of intrafraction couch shifts for proton treatment delivery in head‐and‐neck cancer patients: Toward optimal imaging frequency Open

Nrusingh C. Biswal, Dário B. Rodrigues, Weiguang Yao, Jason K. Molitoris, Matthew E. Witek , et al. · 2022

Purpose Treatment planning for head‐and‐neck (H&N) cancer, in particular oropharynx, nasopharynx, and paranasal sinus cases, at our center requires noncoplanar proton beams due to the complexity of the anatomy and target location. Targetin…

Defining <span>high‐risk</span> elective contralateral neck radiation volumes for oropharynx cancer Open

Matthew E. Witek, N.M. Woody, Hima Bindu Musunuru, Patrick M. Hill, Poonam Yadav , et al. · 2021

Background To define the location of the initial contralateral lymph node (LN) metastasis in patients with oropharynx cancer. Methods The location of the LN centroids from patients with oropharynx cancer and a single radiographically posit…

Impact of the Novel Coronavirus 2019 (COVID‐19) Pandemic on Head and Neck Cancer Care Open

Joshua A. Thompson, Joshua E. Lubek, Neha Amin, Reju Joy, Donita Dyalram , et al. · 2021

Objective The study aimed to assess the impact of the coronavirus disease 2019 (COVID‐19) pandemic on head and neck oncologic care at a tertiary care facility. Study Design This was a cross‐sectional study conducted between March 18, 2020,…

Time to Treatment Analysis of Head and Neck Cancer Patients Undergoing Proton Therapy Open

Danielle Arons, Gregory S. Alexander, Antony Koroulakis, Mark J. Zakhary, Jason K. Molitoris , et al. · 2021

Treatment Outcomes for Advanced Stage Hypopharyngeal Cancer Treated without a GTV to CTV Expansion Open

A. Burr, Paul M. Harari, Alex J. Griffith, Randall J. Kimple, Matthew E. Witek · 2020

Intra-Treatment PET/MRI Separates Intermediate Risk p16-Positive Oropharynx Cancer Patients into Favorable and Unfavorable Cohorts Open

Matthew E. Witek, Paul M. Harari, A. Burr, Thevaa Chandereng, Justine Bruce , et al. · 2020

Clinical outcomes for larynx patients with cancer treated with refinement of high‐dose radiation treatment volumes Open

A. Burr, Paul M. Harari, Alyx M. Haasl, Aaron M. Wieland, Justine Y. Bruce , et al. · 2020

Background To evaluate disease control, toxicities, and dose to dysphagia/aspiration risk structures (DARS) using a direct gross tumor volume (GTV 70Gy ) to planning target volume expansion (dPTV 70Gy ) for patients with squamous cell carc…

Opioid use in patients undergoing treatment for oral cavity cancer. Open

Huaising C. Ko, Mandira N Mehra, A. Burr, Aaron M. Wieland, Randal J Kimple , et al. · 2020

Patients undergoing surgery and adjuvant radiotherapy for oral cavity cancer who required opioids for cancer treatment related pain are at minimal risk for new dependency. Judicious pain management should be applied for patients with a his…

Reducing radiotherapy target volume expansion for patients with HPV-associated oropharyngeal cancer Open

A. Burr, Paul M. Harari, Huaising C. Ko, Justine Y. Bruce, Randall J. Kimple , et al. · 2019

(P31) Patterns of Failure Following Curative Treatment for Oral Cavity Squamous Cell Carcinoma, in Patients Receiving Post-Operative Radiotherapy +/- Chemotherapy, an Institutional Experience Open

Huaising C. Ko, Matthew E. Witek · 2018

NCCN Guidelines Insights: Head and Neck Cancers, Version 1.2018 Open

A. Dimitrios Colevas, Sue S. Yom, David G. Pfister, Sharon Spencer, David J. Adelstein , et al. · 2018

The NCCN Guidelines for Head and Neck (H&N) Cancers provide treatment recommendations for cancers of the lip, oral cavity, pharynx, larynx, ethmoid and maxillary sinuses, and salivary glands. Recommendations are also provided for occult pr…

Impact of HPV Status on the Prognostic Potential of the AJCC Staging System for Larynx Cancer Open

Stacey M. Davidson, Huasing C. Ko, Paul M. Harari, Aaron M. Wieland, Shuai Chen , et al. · 2018

Objective We evaluated the ability of the American Joint Committee on Cancer (AJCC) seventh edition staging system to prognosticate the overall survival of patients with human papillomavirus (HPV)–positive laryngeal squamous cell carcinoma…

Methadone Use During Concurrent Chemoradiation in Patients With Head and Neck Cancer Open

Justine Y. Bruce, G. Harmon, Kaitlin M. Woo, Menggang Yu, J. Kiltz , et al. · 2018

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