Matthew F. Koff
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View article: Exploratory analysis of infrapatellar fat pad MRI-based radiomics for detection of knee structure abnormalities in collegiate basketball players and swimmers
Exploratory analysis of infrapatellar fat pad MRI-based radiomics for detection of knee structure abnormalities in collegiate basketball players and swimmers Open
View article: Paper 06: Immunologic Response of Non-Matched Osteochondral Allografts: A Prospective Study with One-Year Follow-up
Paper 06: Immunologic Response of Non-Matched Osteochondral Allografts: A Prospective Study with One-Year Follow-up Open
Objectives: Fresh osteochondral allograft transplantation (OCA) is commonly used to treat large articular chondral or osteochondral defects, especially in younger patients, because it allows for delivery of mature, viable hyaline cartilage…
View article: Bone texture by clinical magnetic resonance imaging is directly related to bone tissue maturity by Fourier-transform infrared spectroscopy
Bone texture by clinical magnetic resonance imaging is directly related to bone tissue maturity by Fourier-transform infrared spectroscopy Open
Opportunistic screening for osteoporosis using images acquired for other purposes is a burgeoning area that may be of particular utility for the identification of surgical candidates with poor bone health. Texture analysis of clinical MRIs…
View article: In Pursuit of Quantifying Patient Knee Contact Mechanics: Finite Element Model Validation of Cadaveric Knees in Axially Loaded MRI Scans
In Pursuit of Quantifying Patient Knee Contact Mechanics: Finite Element Model Validation of Cadaveric Knees in Axially Loaded MRI Scans Open
Our long‐term objective is to quantify patient‐specific changes in contact mechanics after partial meniscectomy (PM) using knee‐specific finite element (FE) models created from clinical MR scans under axial load. Before creating patient‐sp…
View article: Generating New Meniscus Therapies via Recent Breakthroughs in Development, Model Systems, and Clinical Diagnostics
Generating New Meniscus Therapies via Recent Breakthroughs in Development, Model Systems, and Clinical Diagnostics Open
Over 850,000 surgeries are performed to treat meniscal injuries each year in the United States. Even with repair, patients are likely to develop osteoarthritis (OA) within the next two decades. There is a pressing clinical need to improve …
View article: Novel Noninvasive Imaging Techniques to Assess Structural, Functional, and Material Properties of Tendon, Ligament, and Cartilage: A Narrative Review of Current Concepts
Novel Noninvasive Imaging Techniques to Assess Structural, Functional, and Material Properties of Tendon, Ligament, and Cartilage: A Narrative Review of Current Concepts Open
Background: Novel noninvasive imaging modalities such as quantitative magnetic resonance imaging (qMRI) and shear wave elastography (SWE) allow for assessment of soft tissue microstructure and composition, which ultimately may be associate…
View article: Multiparametric MRI of Knees in Collegiate Basketball Players: Associations With Morphological Abnormalities and Functional Deficits
Multiparametric MRI of Knees in Collegiate Basketball Players: Associations With Morphological Abnormalities and Functional Deficits Open
Background: Rates of cartilage degeneration in asymptomatic elite basketball players are significantly higher compared with the general population due to excessive loads on the knee. Compositional quantitative magnetic resonance imaging (q…
View article: Chondral Injury Associated With ACL Injury: Assessing Progressive Chondral Degeneration With Morphologic and Quantitative MRI Techniques
Chondral Injury Associated With ACL Injury: Assessing Progressive Chondral Degeneration With Morphologic and Quantitative MRI Techniques Open
Background: Anterior cruciate ligament (ACL) injuries are associated with a risk of post-traumatic osteoarthritis due to chondral damage. Magnetic resonance imaging (MRI) techniques provide excellent visualization and assessment of cartila…
View article: The role of advanced metal artifact reduction MRI in the diagnosis of periprosthetic joint infection
The role of advanced metal artifact reduction MRI in the diagnosis of periprosthetic joint infection Open
View article: MRI Advancements in Musculoskeletal Clinical and Research Practice
MRI Advancements in Musculoskeletal Clinical and Research Practice Open
Over the past decades, MRI has become increasingly important for diagnosing and longitudinally monitoring musculoskeletal disorders, with ongoing hardware and software improvements aiming to optimize image quality and speed. However, surgi…
View article: A multimodal assessment of cementless tibial baseplate fixation using radiography, radiostereometric analysis, and magnetic resonance imaging
A multimodal assessment of cementless tibial baseplate fixation using radiography, radiostereometric analysis, and magnetic resonance imaging Open
Fixation in cementless total knee arthroplasty is provided by osseous integration. Radiography, radiostereometric analysis (RSA), and magnetic resonance imaging (MRI) were used simultaneously to investigate fixation. Relationships between …
View article: Opportunistic Evaluation of Trabecular Bone Texture by MRI Reflects Bone Mineral Density and Microarchitecture
Opportunistic Evaluation of Trabecular Bone Texture by MRI Reflects Bone Mineral Density and Microarchitecture Open
Context Many individuals at high risk for fracture are never evaluated for osteoporosis and subsequently do not receive necessary treatment. Utilization of magnetic resonance imaging (MRI) is burgeoning, providing an ideal opportunity to u…
View article: Diffusion-weighted MRI of total hip arthroplasty for classification of synovial reactions: A pilot study
Diffusion-weighted MRI of total hip arthroplasty for classification of synovial reactions: A pilot study Open
View article: MAVRIC based T2 mapping assessment of infrapatellar fat pad scarring in patients with total knee arthroplasty
MAVRIC based T2 mapping assessment of infrapatellar fat pad scarring in patients with total knee arthroplasty Open
The infrapatellar fat pad (IPFP) has been implicated as a source of postoperative knee pain. Imaging the IPFP is challenging in patients with total knee arthroplasty (TKA) due to metallic susceptibility artifact. Multi‐Acquisition Variable…
View article: Multiacquisition Variable-Resonance Image Combination Magnetic Resonance Imaging to Study Detailed Bone Apposition and Fixation of Cementless Knee System Compared to Cemented Total Knee Replacements
Multiacquisition Variable-Resonance Image Combination Magnetic Resonance Imaging to Study Detailed Bone Apposition and Fixation of Cementless Knee System Compared to Cemented Total Knee Replacements Open
View article: Validating the accuracy of multispectral metal artifact suppressed diffusion‐weighted imaging
Validating the accuracy of multispectral metal artifact suppressed diffusion‐weighted imaging Open
Background Diffusion‐weighted imaging (DWI) provides quantitative measurement of random water displacement in tissue as calculated by the apparent diffusion coefficient (ADC). While heavily utilized in stroke and oncology applications, DWI…
View article: Association of circulating gene expression signatures with stiffness following total knee arthroplasty for osteoarthritis: a pilot study
Association of circulating gene expression signatures with stiffness following total knee arthroplasty for osteoarthritis: a pilot study Open
A subset of patients undergoing total knee arthroplasty (TKA) for knee osteoarthritis develop debilitating knee stiffness (reduced range of motion) for poorly understood reasons. Dysregulated inflammatory and immune responses to surgery co…
View article: Animal Models of Bone Marrow Lesions in Osteoarthritis
Animal Models of Bone Marrow Lesions in Osteoarthritis Open
Bone marrow lesions are abnormalities in magnetic resonance images that have been associated with joint pain and osteoarthritis in clinical studies. Increases in the volume of bone marrow lesions have been associated with progression of jo…
View article: Assessment of osteoarthritis functional outcomes and intra‐articular injection volume in the rat anterior cruciate ligament transection model
Assessment of osteoarthritis functional outcomes and intra‐articular injection volume in the rat anterior cruciate ligament transection model Open
The rat surgical anterior cruciate ligament transection (ACLT) model is commonly used to investigate intra‐articular osteoarthritis (OA) therapies, and histological assessment is often the primary outcome measure. However, histological cha…
View article: Reproducibility of pathologic scoring systems for periprosthetic adverse local tissue reactions: A cross-sectional study
Reproducibility of pathologic scoring systems for periprosthetic adverse local tissue reactions: A cross-sectional study Open
View article: The Dorsal Ligament Complex: A Cadaveric, Histology, and Imaging Study
The Dorsal Ligament Complex: A Cadaveric, Histology, and Imaging Study Open
View article: MRI-based Texture Analysis of Trabecular Bone for Opportunistic Screening of Skeletal Fragility
MRI-based Texture Analysis of Trabecular Bone for Opportunistic Screening of Skeletal Fragility Open
Context Many individuals at high risk for osteoporosis and fragility fracture are never screened by traditional methods. Opportunistic use of imaging obtained for other clinical purposes is required to foster identification of these patien…
View article: Effects of the Competitive Season and Off‐Season on Knee Articular Cartilage in Collegiate Basketball Players Using Quantitative MRI: A Multicenter Study
Effects of the Competitive Season and Off‐Season on Knee Articular Cartilage in Collegiate Basketball Players Using Quantitative MRI: A Multicenter Study Open
Background Injuries to the articular cartilage in the knee are common in jumping athletes, particularly high‐level basketball players. Unfortunately, these are often diagnosed at a late stage of the disease process, after tissue loss has a…
View article: Clinical Feasibility of Multi-Acquisition Variable-Resonance Image Combination–Based T2 Mapping near Hip Arthroplasty
Clinical Feasibility of Multi-Acquisition Variable-Resonance Image Combination–Based T2 Mapping near Hip Arthroplasty Open
Background: Hip arthroplasty is increasingly prevalent, and early detection of complications can improve outcomes. Quantitative magnetic resonance imaging (qMRI) methods using multi-acquisition variable-resonance image combination (MAVRIC)…
View article: Differences in the magnetic resonance imaging parameter T2* may be identified during the course of canine patellar tendon healing: a pilot study
Differences in the magnetic resonance imaging parameter T2* may be identified during the course of canine patellar tendon healing: a pilot study Open
These findings display tendon healing in response to an imposed strain and present the utility of qMRI to evaluate longitudinal differences of patellar tendon T2* values in a model of induced subclinical tendon damage. The qMRI technique o…
View article: Multiparametric MRI characterization of knee articular cartilage and subchondral bone shape in collegiate basketball players
Multiparametric MRI characterization of knee articular cartilage and subchondral bone shape in collegiate basketball players Open
Magnetic resonance imaging (MRI) is commonly used to evaluate the morphology of the knee in athletes with high‐knee impact; however, complex repeated loading of the joint can lead to biochemical and structural degeneration that occurs befo…
View article: Multiacquisition Variable-Resonance Image Combination Magnetic Resonance Imaging Used to Study Detailed Bone Apposition and Fixation of an Additively Manufactured Cementless Acetabular Shell
Multiacquisition Variable-Resonance Image Combination Magnetic Resonance Imaging Used to Study Detailed Bone Apposition and Fixation of an Additively Manufactured Cementless Acetabular Shell Open
Using multiacquisition variable-resonance image combination selective MRI, our analysis showed greater osteointegration and less fibrous membrane formation in the 3-dimensionally printed cups than the control group at 1-year follow-up.
View article: Preliminary longitudinal analysis of knee articular cartilage and knee health in collegiate basketball players and swimmers
Preliminary longitudinal analysis of knee articular cartilage and knee health in collegiate basketball players and swimmers Open
View article: Multivariate use of MRI biomarkers to classify histologically confirmed necrosis in symptomatic total hip arthroplasty
Multivariate use of MRI biomarkers to classify histologically confirmed necrosis in symptomatic total hip arthroplasty Open
The failure of total hip arthroplasty (THA) is commonly associated with the necrosis of the periprosthetic tissue. To date, there is no established method to noninvasively quantify the progression of such necrosis. Magnetic resonance imagi…
View article: Clinical magnetic resonance imaging of arthroplasty at 1.5 T
Clinical magnetic resonance imaging of arthroplasty at 1.5 T Open
Magnetic resonance imaging (MRI) has historically been avoided for the routine clinical evaluation of metal implants at many clinical centers due to the presence of artifact that creates in‐plane and through‐plane distortions and signal in…