Matthew Clark
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View article: Use of <i>Haemophilus influenzae</i> Type b–Containing Vaccines Among American Indian and Alaska Native Infants: Updated Recommendations of the Advisory Committee on Immunization Practices ― United States, 2024
Use of <i>Haemophilus influenzae</i> Type b–Containing Vaccines Among American Indian and Alaska Native Infants: Updated Recommendations of the Advisory Committee on Immunization Practices ― United States, 2024 Open
Invasive Haemophilus influenzae type b (Hib) disease is a serious bacterial infection that disproportionally affects American Indian and Alaska Native (AI/AN) populations. Hib vaccination with a monovalent Hib conjugate vaccine consisting …
View article: Prospective validation of clinical deterioration predictive models prior to intensive care unit transfer among patients admitted to acute care cardiology wards
Prospective validation of clinical deterioration predictive models prior to intensive care unit transfer among patients admitted to acute care cardiology wards Open
Objective . Very few predictive models have been externally validated in a prospective cohort following the implementation of an artificial intelligence analytic system. This type of real-world validation is critically important due to the…
View article: Prospective validation of clinical deterioration predictive models prior to intensive care unit transfer among patients admitted to acute care cardiology wards
Prospective validation of clinical deterioration predictive models prior to intensive care unit transfer among patients admitted to acute care cardiology wards Open
Very few predictive models have been externally validated in a prospective cohort following the implementation of an artificial intelligence analytic system. This type of real-world validation is critically important due to the risk of dat…
View article: Second row of eyelashes with lower extremity edema
Second row of eyelashes with lower extremity edema Open
A 71-year-old male presented for a full-body skin examination due to a history of basal cell and squamous cell carcinoma. Physical examination revealed a second row of eyelashes emerging from the meibomian gland on bilateral upper and lowe…
View article: Overt and Occult Hypoxemia in Patients Hospitalized With COVID-19
Overt and Occult Hypoxemia in Patients Hospitalized With COVID-19 Open
IMPORTANCE: Progressive hypoxemia is the predominant mode of deterioration in COVID-19. Among hypoxemia measures, the ratio of the Pa o 2 to the F io 2 (P/F ratio) has optimal construct validity but poor availability because it requires ar…
View article: Accuracy of a Risk Alert Threshold for ICU Hypoglycemia: Retrospective Analysis of Alert Performance and Association With Clinical Deterioration Events
Accuracy of a Risk Alert Threshold for ICU Hypoglycemia: Retrospective Analysis of Alert Performance and Association With Clinical Deterioration Events Open
OBJECTIVES: To quantify the accuracy of and clinical events associated with a risk alert threshold for impending hypoglycemia during ICU admissions. DESIGN: Retrospective electronic health record review of clinical events occurring greater…
View article: Signatures of illness in children requiring unplanned intubation in the pediatric intensive care unit: A retrospective cohort machine-learning study
Signatures of illness in children requiring unplanned intubation in the pediatric intensive care unit: A retrospective cohort machine-learning study Open
Acute respiratory failure requiring the initiation of invasive mechanical ventilation remains commonplace in the pediatric intensive care unit (PICU). Early recognition of patients at risk for respiratory failure may provide clinicians wit…
View article: Beyond prediction: Off‐target uses of artificial intelligence‐based predictive analytics in a learning health system
Beyond prediction: Off‐target uses of artificial intelligence‐based predictive analytics in a learning health system Open
Introduction Artificial‐intelligence (AI)‐based predictive analytics provide new opportunities to leverage rich sources of continuous data to improve patient care through early warning of the risk of clinical deterioration and improved sit…
View article: Overt and occult hypoxemia in patients hospitalized with novel coronavirus disease 2019
Overt and occult hypoxemia in patients hospitalized with novel coronavirus disease 2019 Open
Background Progressive hypoxemia is the predominant mode of deterioration in COVID-19. Among hypoxemia measures, the ratio of the partial pressure of arterial oxygen to the fraction of inspired oxygen (P/F ratio) has optimal construct vali…
View article: Accuracy of a Risk Alert Threshold for ICU Hypoglycemia: Retrospective Analysis of Alert Performance and Association with Clinical Deterioration Events
Accuracy of a Risk Alert Threshold for ICU Hypoglycemia: Retrospective Analysis of Alert Performance and Association with Clinical Deterioration Events Open
Objective To quantify the accuracy of and clinical events associated with a risk alert threshold for impending hypoglycemia during ICU admissions. Design Retrospective electronic health record review of clinical events occurring ≥1 and ≤12…
View article: 484. Identification of Early Features to Differentiate Hospitalized Children Admitted for Suspected MIS-C from Alternative Diagnoses
484. Identification of Early Features to Differentiate Hospitalized Children Admitted for Suspected MIS-C from Alternative Diagnoses Open
Background Multi-system inflammatory syndrome in children (MIS-C) is a rare consequence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). MIS-C shares features with common infectious and inflammatory syndromes and differenti…
View article: External validation of a novel signature of illness in continuous cardiorespiratory monitoring to detect early respiratory deterioration of ICU patients
External validation of a novel signature of illness in continuous cardiorespiratory monitoring to detect early respiratory deterioration of ICU patients Open
Objective: The goal of predictive analytics monitoring is the early detection of patients at high risk of subacute potentially catastrophic illnesses. An excellent example of a targeted illness is respiratory failure leading to urgent unpl…
View article: Predictive Monitoring–Impact in Acute Care Cardiology Trial (PM-IMPACCT): Protocol for a Randomized Controlled Trial
Predictive Monitoring–Impact in Acute Care Cardiology Trial (PM-IMPACCT): Protocol for a Randomized Controlled Trial Open
Background Patients in acute care wards who deteriorate and are emergently transferred to intensive care units (ICUs) have poor outcomes. Early identification of patients who are decompensating might allow for earlier clinical intervention…
View article: External Validation Of A Novel Signature Of Illness In Continuous Cardiorespiratory Monitoring To Detect Early Respiratory Deterioration Of ICU Patients
External Validation Of A Novel Signature Of Illness In Continuous Cardiorespiratory Monitoring To Detect Early Respiratory Deterioration Of ICU Patients Open
The goal of predictive analytics monitoring is the early detection of patients at high risk of subacute potentially catastrophic illnesses. An excellent example of a targeted illness is respiratory failure leading to urgent unplanned intub…
View article: Predictive Monitoring–Impact in Acute Care Cardiology Trial (PM-IMPACCT): Protocol for a Randomized Controlled Trial (Preprint)
Predictive Monitoring–Impact in Acute Care Cardiology Trial (PM-IMPACCT): Protocol for a Randomized Controlled Trial (Preprint) Open
BACKGROUND Patients in acute care wards who deteriorate and are emergently transferred to intensive care units (ICUs) have poor outcomes. Early identification of patients who are decompensating might allow for earlier clinical interventio…
View article: Synergistic effect of sleep depth and seizures correlates with postictal heart rate
Synergistic effect of sleep depth and seizures correlates with postictal heart rate Open
Our objective was to determine the effect of sleep on heart rate following a recorded seizure. We prospectively acquired heart rate data in hospitalized epilepsy monitoring unit patients. We analyzed heart rate trends for multiple seizures…
View article: Pathophysiologic Signatures of Bloodstream Infection in Critically Ill Adults
Pathophysiologic Signatures of Bloodstream Infection in Critically Ill Adults Open
Objectives: Bloodstream infection is associated with high mortality rates in critically ill patients but is difficult to identify clinically. This results in frequent blood culture testing, exposing patients to additional costs as well as …
View article: Early Detection of In-Patient Deterioration: One Prediction Model Does Not Fit All
Early Detection of In-Patient Deterioration: One Prediction Model Does Not Fit All Open
Objectives: Early detection of subacute potentially catastrophic illnesses using available data is a clinical imperative, and scores that report risk of imminent events in real time abound. Patients deteriorate for a variety of reasons, an…
View article: Early detection of in-patient deterioration: one prediction model does not fit all
Early detection of in-patient deterioration: one prediction model does not fit all Open
Objectives Early detection of subacute potentially catastrophic illnesses using available data is a clinical imperative, and scores that report risk of imminent events in real time abound. Patients deteriorate for a variety of reasons, and…
View article: Type 1 Diabetes: A Chronic Anti-Self-Inflammatory Response
Type 1 Diabetes: A Chronic Anti-Self-Inflammatory Response Open
Inflammation is typically induced in response to a microbial infection. The release of proinflammatory cytokines enhances the stimulatory capacity of antigen-presenting cells, as well as recruits adaptive and innate immune effectors to the…
View article: 112. Physiological Signature of Bloodstream Infection in Critically Ill Patients
112. Physiological Signature of Bloodstream Infection in Critically Ill Patients Open
Background Bloodstream infection (BSI) is associated with high mortality rates in critically ill patients but is difficult to identify clinically. This uncertainty results in frequent blood culture testing, which exposes patients to additi…
View article: Identifying the low risk patient in surgical intensive and intermediate care units using continuous monitoring
Identifying the low risk patient in surgical intensive and intermediate care units using continuous monitoring Open
An ensemble model for critical illness predicts favorable outcome after downgrade and safe patient discharge (hospital stay <7 days, no readmission, upgrade, or death).
View article: Cardiorespiratory dynamics measured from continuous ECG monitoring improves detection of deterioration in acute care patients: A retrospective cohort study
Cardiorespiratory dynamics measured from continuous ECG monitoring improves detection of deterioration in acute care patients: A retrospective cohort study Open
Cardiorespiratory dynamics from continuous ECG monitoring detect clinical deterioration in acute care patients and improve performance of conventional models that use only laboratory results and vital signs.
View article: Patients’ perceptions of gastroenterologists’ attire in the clinic and endoscopy suite
Patients’ perceptions of gastroenterologists’ attire in the clinic and endoscopy suite Open
Gastroenterologists' attire does influence patients' perception of the care they are receiving. There is an overall preference for the use of scrubs in the different settings of gastroenterology, both office and lab.